scholarly journals Cerebellar Pathology of a Dual Clinical Diagnosis: Patients with Essential Tremor and Dystonia

2012 ◽  
Vol 2 (0) ◽  
pp. 12 ◽  
Author(s):  
Karen Ma ◽  
Rachel Babij ◽  
Etty Cortés ◽  
Jean-Paul G. Vonsattel ◽  
Elan D. Louis
Keyword(s):  
Essential Tremor ◽  
Clinical Diagnosis

Essential Tremor: Five New Things

2021 ◽  
pp. 10.1212/CPJ.0000000000001145
Author(s):  
Abhishek Lenka ◽  
Sanjay Pandey
Keyword(s):  
Magnetic Resonance ◽  
Essential Tremor ◽  
Clinical Diagnosis ◽  
Focused Ultrasound ◽  
Consensus Statement ◽  
Cerebellar Degeneration ◽  
Considerable Progress ◽  
Clinical Aspects ◽  
Definition Of

ABSTRACTPurpose of the review:To highlight five new things in the research and clinical aspects of essential tremor (ET).Recent findings:The introduction of a new definition of ET and a new category “ET plus” were the major themes of the recent consensus statement. This new change demands a change in the approach to the clinical diagnosis of ET and related diseases. From the pathogenesis standpoint, the cerebellar neurodegenerative model seems to have numerous evidence in its favor compared to the olivary model which has largely fallen out of favor. From the standpoint of therapeutics, magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy has enriched the therapeutic armamentarium.Summary:There has been considerable progress in the field of ET. We discuss five new things in this article which include- (i) new definition (ii) ET plus (iii) approach to the diagnosis of ET, (iv) cerebellar degeneration, and (v) MRgFUS thalamotomy.

EXPERTISE OF DISABILITY IN ESSENTIAL TREMOR

2018 ◽  
Vol 4 (1-2) ◽  
pp. 20-25
Author(s):  
O.P. Onopriyenko
Keyword(s):  
Essential Tremor ◽  
Clinical Diagnosis ◽  
Early Diagnostics ◽  
Prevention Of Disability

The purpose of our research was to study the medical and social expertise, early diagnostics, examples of the formulation of a clinical diagnosis, as well as current issues on the prevention of disability, and the principles of rehabilitation in essential tremor. Keywords: essential tremor, classification, treatment, expertise of disability, prophylaxis, rehabilitation.

Agreement among movement disorder specialists on the clinical diagnosis of essential tremor

1997 ◽  
Vol 12 (6) ◽  
pp. 973-976 ◽  
Author(s):  
Sylvain Chouinard ◽  
Elan D. Louis ◽  
Stanley Fahn
Keyword(s):  
Movement Disorder ◽  
Essential Tremor ◽  
Clinical Diagnosis

scholarly journals Inter-Rater Agreement in the Clinical Diagnosis of Essential Tremor: Data from the NEDICES-2 Pilot Study

2014 ◽  
Vol 4 (0) ◽  
pp. 04
Author(s):  
Fernando Sierra-Hidalgo ◽  
Juan Pablo Romero ◽  
Felix Bermejo-Pareja ◽  
Alvaro Sánchez-Ferro ◽  
Jesús Hernández-Gallego ◽  
...  
Keyword(s):  
Pilot Study ◽  
Essential Tremor ◽  
Clinical Diagnosis ◽  
Rater Agreement

scholarly journals The detection of hand tremor through the characteristics of finger movement while typing

2018 ◽  
Author(s):  
Warwick R. Adams
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Clinical Diagnosis ◽  
Finger Movement ◽  
Hand Tremor ◽  
Novel Technique

AbstractParkinson’s Disease (PD) is a neurodegenerative movement disease affecting over 6 million people worldwide. Current diagnosis is based on clinical and observational criteria only, resulting in a high misdiagnosis rate. Approximately 75% of people with PD have hand tremor, which can precede clinical diagnosis by up to 6 years. Previous studies have shown that early PD can be accurately detected from keystroke features while typing, and this study investigated whether tremor can be detected as well. Typing data from 76 subjects, with and without PD, including 27 with PD and 15 with tremor, was analysed and showed that hand tremor in PD can be detected from keystroke features. This novel technique has not been used before and was able to achieve an overall sensitivity of 67% and a specificity of 80% and was also able to differentiate PD tremor from essential tremor. This means that the diagnosis of early PD through typing can achieve the clinical requirement of at least two cardinal features being present (bradykinesia and tremor). Less than half a page of typing is needed, the technique does not require any specialised equipment, and can take place in the patient’s home as they type normally on a computer.

scholarly journals Accuracy of nigrosome-1 detection to discriminate patients with Parkinson’s disease and essential tremor

2019 ◽  
Vol 32 (6) ◽  
pp. 395-400 ◽  
Author(s):  
Manuel S Perez Akly ◽  
Carla V Stefani ◽  
Lucía Ciancaglini ◽  
José S Bestoso ◽  
Jorge A Funes ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
Essential Tremor ◽  
Clinical Diagnosis ◽  
Susceptibility Weighted Imaging ◽  
Resonance Imaging ◽  
Clinical Patient ◽  
Early Stages

Purpose The use of susceptibility weighted imaging in high field magnetic resonance imaging scanners can detect the nigrosome-1 area located in the caudo-lateral region of the pars compacta in the substantia nigra. This structure comprises a significant amount of dopaminergic neurons and degenerates in the early stages of Parkinson’s disease. Essential tremor is a neurological condition that in some cases could be confused with the early stages of Parkinson’s disease with a possible error in clinical diagnosis. Our purpose is to evaluate the accuracy of nigrosome-1 detection by high resolution magnetic resonance imaging to discriminate Parkinson’s disease from essential tremor. Methods A case–control study compared patients with a clinical diagnosis of Parkinson’s disease and essential tremor. Magnetic resonance imaging studies were performed using a 3T magnetic resonance imaging scanner. The susceptibility weighted imaging sequence was obtained in the axial plane with an isotropic voxel of 0.75 mm. Two independent neuroradiologists evaluated the images without access to clinical patient data. Results Sixteen patients were included in each group (Parkinson’s disease and essential tremor). Average age: Parkinson’s disease group: 71.3 (SD 6.3) and essential tremor group: 68.3 (SD 12.3). For the first evaluator, the nigrosome-1 area was absent in 15 patients with Parkinson’s disease and in two with essential tremor and for the second evaluator was absent in 15 patients with Parkinson’s disease and four with essential tremor. The sensitivity/specificity for the diagnosis of Parkinson’s disease was 93.75%/87.5% for the first evaluator and 93.75%/75% for the second evaluator. Conclusion The detection of the nigrosome-1 area is a useful tool in the differential diagnosis between Parkinson’s disease and essential tremor, with high sensitivity and specificity.

scholarly journals Analysis of Fine Motor Skills in Essential Tremor: Combining Neuroimaging and Handwriting Biomarkers for Early Management

2021 ◽  
Vol 15 ◽  
Author(s):  
Karmele Lopez-de-Ipina ◽  
Jordi Solé-Casals ◽  
José Ignacio Sánchez-Méndez ◽  
Rafael Romero-Garcia ◽  
Elsa Fernandez ◽  
...  
Keyword(s):  
Essential Tremor ◽  
Clinical Diagnosis ◽  
Motor Skills ◽  
Fine Motor ◽  
Fine Motor Skills ◽  
Hand Tremor ◽  
Early Management ◽  
Support Tool ◽  
Clinical Biomarkers ◽  
Novel Approach

Essential tremor (ET) is a highly prevalent neurological disorder characterized by action-induced tremors involving the hand, voice, head, and/or face. Importantly, hand tremor is present in nearly all forms of ET, resulting in impaired fine motor skills and diminished quality of life. To advance early diagnostic approaches for ET, automated handwriting tasks and magnetic resonance imaging (MRI) offer an opportunity to develop early essential clinical biomarkers. In this study, we present a novel approach for the early clinical diagnosis and monitoring of ET based on integrating handwriting and neuroimaging analysis. We demonstrate how the analysis of fine motor skills, as measured by an automated Archimedes’ spiral task, is correlated with neuroimaging biomarkers for ET. Together, we present a novel modeling approach that can serve as a complementary and promising support tool for the clinical diagnosis of ET and a large range of tremors.

Study on erythrocytes by SEM photogrammetry (SEMP) technique

1990 ◽  
Vol 48 (3) ◽  
pp. 724-725
Author(s):  
Tong Wensheng ◽  
Lu Lianhuang ◽  
Zhang Zhijun
Keyword(s):  
Quantitative Analysis ◽  
Cell Membrane ◽  
Clinical Diagnosis ◽  
Human Body ◽  
Blood Cells ◽  
Three Dimensional ◽  
Normal Person ◽  
Blood Disease ◽  
Computation Technique ◽  
Important Basis

This is a combined study of two diffirent branches, photogrammetry and morphology of blood cells. The three dimensional quantitative analysis of erythrocytes using SEMP technique, electron computation technique and photogrammetry theory has made it possible to push the study of mophology of blood cells from LM, TEM, SEM to a higher stage, that of SEM P. A new path has been broken for deeply study of morphology of blood cells.In medical view, the abnormality of the quality and quantity of erythrocytes is one of the important changes of blood disease. It shows the abnormal blood—making function of the human body. Therefore, the study of the change of shape on erythrocytes is the indispensable and important basis of reference in the clinical diagnosis and research of blood disease.The erythrocytes of one normal person, three PNH Patients and one AA patient were used in this experiment. This research determines the following items: Height;Length of two axes (long and short), ratio; Crevice in depth and width of cell membrane; Circumference of erythrocytes; Isoline map of erythrocytes; Section map of erythrocytes.

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