scholarly journals Effects of Eccentric Exercise on Skeletal Muscle Injury: From An Ultrastructure Aspect: A Review

2021 ◽  
Vol 5 (1) ◽  
pp. 15-20
Author(s):  
Jianhua Ying ◽  
Xuanzhen Cen ◽  
Peimin Yu
2020 ◽  
Vol 27 (4) ◽  
pp. e72-e79 ◽  
Author(s):  
Congcong Fu ◽  
Yu Xia ◽  
Fan Meng ◽  
Fei Li ◽  
Qiang Liu ◽  
...  

2005 ◽  
Vol 15 (4) ◽  
pp. 401-412 ◽  
Author(s):  
Richard J. Bloomer ◽  
Andrew Fry ◽  
Brian Schilling ◽  
Loren Chiu ◽  
Naruhiro Hori ◽  
...  

This investigation was designed to determine the effects of astaxanthin on markers of skeletal muscle injury. Twenty resistance trained men (mean ± standard error of the mean: age, 25.1 ± 1.6 y; height, 1.79 ± 0.02 m; weight, 86.8 ± 4.4 kg) were assigned to either a placebo (1732 mg safflower oil, n = 10) or astaxanthin (BioAstin; 1732 mg safflower oil; haematococcus algae extract [contains 4 mg astaxanthin and 480 mg lutein], n = 10). Subjects consumed their assigned treatment for 3 wk prior to eccentric exercise (10 sets of 10 repetitions at 85% of one repetition maximum) and through 96 h post-exercise. Muscle soreness, creatine kinase (CK), and muscle performance was measured before and through 96 h post-exercise. A similar response was observed for both treatment groups for all dependent variables, indicating that in resistance trained men, astaxanthin supplementation does not favorably affect indirect markers of skeletal muscle injury following eccentric loading.


2016 ◽  
Vol 4 (9) ◽  
pp. e12777 ◽  
Author(s):  
John W. Castellani ◽  
Edward J. Zambraski ◽  
Michael N. Sawka ◽  
Maria L. Urso

2010 ◽  
Vol 299 (1) ◽  
pp. R259-R267 ◽  
Author(s):  
Ruibo Wang ◽  
Maria L. Urso ◽  
Edward J. Zambraski ◽  
Erik P. Rader ◽  
Kevin P. Campbell ◽  
...  

Effective therapy to reduce skeletal muscle injury associated with severe or eccentric exercise is needed. The purpose of this study was to determine whether adenosine receptor stimulation can mediate protection from eccentric exercise-induced muscle injury. Downhill treadmill exercise (−15°) was used to induce eccentric exercise-mediated skeletal muscle injury. Experiments were conducted in both normal wild-type (WT) mice and also in β-sarcoglycan knockout dystrophic mice, animals that show an exaggerated muscle damage with the stress of exercise. In the vehicle-treated WT animals, eccentric exercise increased serum creatine kinase (CK) greater than 3-fold to 358.9 ± 62.7 U/l (SE). This increase was totally abolished by stimulation of the A3 receptor. In the dystrophic β-sarcoglycan-null mice, eccentric exercise caused CK levels to reach 55,124 ± 5,558 U/l. A3 receptor stimulation in these animals reduced the CK response by nearly 50%. In the dystrophic mice at rest, 10% of the fibers were found to be damaged, as indicated by Evans blue dye staining. While this percentage was doubled after exercise, A3 receptor stimulation eliminated this increase. Neither the A1 receptor agonist 2-chloro- N6-cyclopentyladenosine (0.05 mg/kg) nor the A2A receptor agonist 2- p-(2-carboxyethyl)phenethylamino-5′- N-ethylcarboxamidoadenosine (0.07 mg/kg) protected skeletal muscle from eccentric exercise injury in WT or dystrophic mice. The protective effect of adenosine A3 receptor stimulation was absent in mice, in which genes for phospholipase C β2/β3 (PLCβ2/β3) and β-sarcoglycan were deleted. The present study elucidates a new protective role of the A3 receptor and PLCβ2/β3 and points to a potentially effective therapeutic strategy for eccentric exercise-induced skeletal muscle injury.


2007 ◽  
Vol 2 (1) ◽  
pp. 13 ◽  
Author(s):  
Yang-Hwei Tsuang ◽  
Shui-Ling Lam ◽  
Lien-Chen Wu ◽  
Chang-Jung Chiang ◽  
Li-Ting Chen ◽  
...  

2009 ◽  
Vol 28 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Andres J. Quintero ◽  
Vonda J. Wright ◽  
Freddie H. Fu ◽  
Johnny Huard

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