Adjuvant CCNU (Lomustine) and Prednisone Chemotherapy for Dogs With Incompletely Excised Grade 2 Mast Cell Tumors

2009 ◽  
Vol 45 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Kenji Hosoya ◽  
William C. Kisseberth ◽  
Francisco J. Alvarez ◽  
Ana Lara-Garcia ◽  
Gillian Beamer ◽  
...  
Keyword(s):  
Mast Cell ◽  
Radiation Therapy ◽  
Local Recurrence ◽  
Medical Records ◽  
Local Recurrence Rate ◽  
Distant Metastases ◽  
Surgical Excision ◽  
Mast Cell Tumors ◽  
Fatal Liver Failure ◽  
Metastasis Rate

The use of adjuvant 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; lomustine) to treat incompletely excised canine mast cell tumors (MCTs) has not been evaluated. Medical records of 12 dogs with grade 2 MCT treated with incomplete surgical excision and adjuvant CCNU and prednisone chemotherapy were reviewed. Local recurrence rate, metastasis rate, and survival time were evaluated. None of the dogs developed local recurrence or regional/ distant metastases. Two dogs developed fatal liver failure. The 1- and 2-year progression-free rates of surviving dogs were 100% and 77%, respectively. Postoperative adjuvant CCNU appears to be a useful alternative to radiation therapy for incompletely excised canine cutaneous MCTs.

Periocular cutaneous mast cell tumors in cats: evaluation of surgical excision (33 cases)

2010 ◽  
Vol 13 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Keith W. Montgomery ◽  
Alexandra van der Woerdt ◽  
Susette M. Aquino ◽  
John S. Sapienza ◽  
Eric C. Ledbetter
Keyword(s):  
Mast Cell ◽  
Surgical Excision ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell

Chondrogenic neoplasms of the nasal cavity

1987 ◽  
Vol 101 (5) ◽  
pp. 500-505 ◽  
Author(s):  
O. E. El-Silimy ◽  
L. Harvey ◽  
M.R.C. Path ◽  
P. J. Bradley
Keyword(s):  
Local Recurrence ◽  
Nasal Cavity ◽  
Initial Treatment ◽  
Distant Metastases ◽  
Surgical Excision ◽  
Natural Course ◽  
Facial Skeleton ◽  
Histological Differentiation

Chondrogenic neoplasms of the nasal cavity are rare. Clinically, presentation is often late, with expansion and destruction of the middle facial skeleton. Local radical surgical excision is the preferred treatment, with regular life-long follow-up. Risk of local recurrence and distant metastases may Qccur many years after initial treatment. All chondrogenic tumours should be carefully followed up because the natural course of the disease may not match the histological differentiation.

Recurrence Rates and Sites for Grade II Canine Cutaneous Mast Cell Tumors Following Complete Surgical Excision

2002 ◽  
Vol 38 (1) ◽  
pp. 71-73 ◽  
Author(s):  
Chick Weisse ◽  
Frances S. Shofer ◽  
Karin Sorenmo
Keyword(s):  
Mast Cell ◽  
Tumor Recurrence ◽  
Surgical Excision ◽  
Adjuvant Radiation ◽  
Recurrence Rates ◽  
Mast Cell Tumors ◽  
Complete Surgical Excision ◽  
Grade Ii ◽  
Cutaneous Mast Cell ◽  
Distant Tumor

A retrospective study was performed on 31 dogs with completely excised, grade II, cutaneous mast cell tumors in order to determine recurrence rates and sites. Distant tumor recurrence developed in 22% of dogs, and local tumor recurrence developed in 11% of dogs; however, the vast majority of these animals were incompletely staged initially. Complete surgical excision of grade II mast cell tumors was associated with effective local control in 89% of these dogs. Therefore, adjuvant radiation therapy might not be indicated in the majority of dogs with complete surgical excision.

scholarly journals A Prospective Study of Radiation Therapy for the Treatment of Grade 2 Mast Cell Tumors in 32 Dogs

1996 ◽  
Vol 10 (6) ◽  
pp. 376-378 ◽  
Author(s):  
Renee Al-Sarraf ◽  
G. Neal Mauldin ◽  
Amiya K. Patnaik ◽  
Karri A. Meleo
Keyword(s):  
Mast Cell ◽  
Radiation Therapy ◽  
Prospective Study ◽  
Mast Cell Tumors ◽  
A Prospective Study

Prognostic factors in dogs with osteosarcomas of the flat or irregular bones

1995 ◽  
Vol 31 (4) ◽  
pp. 321-326 ◽  
Author(s):  
AS Hammer ◽  
FR Weeren ◽  
SE Weisbrode ◽  
SL Padgett
Keyword(s):  
Body Weight ◽  
Prognostic Factors ◽  
Local Recurrence ◽  
Survival Time ◽  
Medical Records ◽  
Median Survival Time ◽  
Surgical Excision ◽  
Survival Times ◽  
Anatomic Site ◽  
Common Cause

The medical records of 45 dogs with histopathologically confirmed osteosarcomas arising from flat or irregular bones were reviewed. Thirty-five percent of the dogs eventually developed metastases. Telangectatic tumors and tumors arising from the rib and scapula had the highest prevalence of metastases. Survival times were short, with an overall median survival time of 120 days. Anatomic site, body weight, and completeness of surgical excision were found to be prognostic factors. Dogs with mandibular osteosarcomas in this study had shorter survival times than those times recently reported. 21 Local recurrence was the most common cause of death or euthanasia in this population of dogs.

Vinblastine and Prednisolone as Adjunctive Therapy for Canine Cutaneous Mast Cell Tumors

2004 ◽  
Vol 40 (2) ◽  
pp. 124-130 ◽  
Author(s):  
David R. Davies ◽  
Kenneth M. Wyatt ◽  
John E. Jardine ◽  
Ian D. Robertson ◽  
Peter J. Irwin
Keyword(s):  
Mast Cell ◽  
Local Recurrence ◽  
Adjunctive Therapy ◽  
Marginal Excision ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell ◽  
Residual Microscopic Disease ◽  
Related Mortality

Twenty-seven dogs with inadequately excised, cutaneous mast cell tumors (MCT; 20 residual microscopic disease, seven marginal excision) were treated with a vinblastine and prednisolone chemotherapeutic protocol. Twenty dogs were available for follow-up examination after 12 months. One dog suffered local recurrence of the tumor, four dogs developed new cutaneous tumors, and one dog had both events. Fourteen dogs were free of MCT. There was no confirmed tumor-related mortality. Although toxicity from the chemotherapy was generally mild, one dog died of sepsis during treatment.

Clinical Outcome for MCTs of Canine Pinnae Treated with Surgical Excision (2004–2008)

2014 ◽  
Vol 50 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Timothy M. Schwab ◽  
Catherine Popovitch ◽  
John DeBiasio ◽  
Michael Goldschmidt
Keyword(s):  
Local Recurrence ◽  
Surgical Excision ◽  
Tumor Grade ◽  
Published Data ◽  
Disease Free Interval ◽  
Mast Cell Tumors ◽  
Grade 3 ◽  
Record Review ◽  
Disease Free

Canine mast cell tumors (MCTs) are the most common cutaneous neoplasm in the dog. It has been suggested that MCT in certain locations may behave in a more biologically aggressive fashion than MCTs located in others; however, no published data are available for MCTs of canine pinnae treated with surgical excision. A retrospective study of 28 animals with surgical excision of MCTs of pinnae was completed with a medical record review and follow-up questionnaire to the operating veterinarian. The effect of tumor grade, clean or dirty excision, cartilage penetration, and mitotic index (MI) on local recurrence and survival time (ST) was evaluated. There was local recurrence in one dog with a grade 2 MCT and in seven of eight dogs with grade 3 MCTs. The median ST of animals with grade 1 and 2 MCTs was not reached, whereas the median ST of animals with grade 3 MCTs was 10 mo. There was no statistical association between histologically clean and dirty margins and either local recurrence or ST. A prolonged disease free interval without local recurrence may be achieved with local excision of grade 1 and 2 MCTs. Animals with grade 3 MCTs had a uniformly poor outcome with short times to local recurrence and death.

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