A Combination of Oral Cabergoline and Double Cloprostenol Injections to Produce Third-Quarter Gestation Termination in the Bitch

2006 ◽  
Vol 42 (5) ◽  
pp. 366-370 ◽  
Author(s):  
Yanina Corrada ◽  
Raúl Rodríguez ◽  
Mariana Tortora ◽  
Daniel Arias ◽  
Cristina Gobello
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Untreated Control ◽  
Ultrasound Examination ◽  
Pregnancy Termination ◽  
Control Group ◽  
Efficacy And Safety ◽  
Untreated Control Group

To assess the efficacy and safety of a combined cabergoline and cloprostenol protocol to terminate third-quarter pregnancy, 22 pregnant bitches that ranged from 35 to 45 days after mating were randomly assigned to a treatment group (n=13) or to an untreated control group (n=9). The animals were monitored for 12 days, and pregnancy termination was confirmed by ultrasound examination. Twelve of the 13 treated bitches aborted within 9 days of the initiation of treatment (mean 4.6 days). Only mild side effects were observed. The control animals had normal gestational courses, as did the bitch that did not respond to the therapy. This combination of drugs appeared to be a practical, safe, and efficient abortifacient when used in third-quarter pregnancies.

scholarly journals Evaluation of a marketed polyherbal dewormer against intestinal strongyles in naturally infected donkeys

2020 ◽  
Vol 57 (1) ◽  
pp. 78-82 ◽  
Author(s):  
R. A. Papini ◽  
C. Orsetti ◽  
M. Sgorbini
Keyword(s):  
Treatment Group ◽  
Untreated Control ◽  
No Reduction ◽  
Additional Treatment ◽  
Control Group ◽  
Untreated Control Group ◽  
Fecal Samples ◽  
Faecal Egg Count

SummaryThe study evaluated the effectiveness of a commercially available polyherbal dewormer to control intestinal strongyles in naturally infected donkeys. The animals were allotted to two groups: treated with the herbal dewormer (n=8) according to manufacturer recommendations and untreated control group (n=6). Fecal samples were taken from each animal on days 0 (day of treatment), 14, 21 (day of second additional treatment), 35, and 42. Faecal egg count reduction tests showed very negligible or no reduction in number of strongyle eggs for donkeys in the phytotherapeutic treatment group compared to those in the control group. Thus, the herbal dewormer was mostly ineffective in reducing fecal egg counts in donkeys infected with intestinal strongyles. These findings can make equine practitioners aware of possible disadvantages of herbal dewormers.

scholarly journals Study Protocol for Multi-Center, Open-Label, Randomized Controlled Trial for Assessing the Efficacy and Safety of Electroacupuncture for Cold Hypersensitivity in Hands and Feet

2021 ◽  
Author(s):  
Kyou-Young Lee ◽  
In-Sik Han ◽  
Dong-Nyung Lee ◽  
Dong-Il Kim ◽  
Junsang Yu ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Treatment Group ◽  
Acupuncture Treatment ◽  
Control Group ◽  
Efficacy And Safety ◽  
Untreated Control Group ◽  
Hands And Feet ◽  
Cold Hypersensitivity

Abstract Background: Cold hypersensitivity in the hands and feet (CHHF) is defined as the symptom of a sensation of coldness in the extremities under conditions that are not considered cold by an unaffected person. CHHF is common in East Asian women. CHHF can affect the quality of life by placing restrictions on one's daily activities. Although electroacupuncture (EA) and acupuncture have been widely used for treating CHHF, randomized clinical trial (RCT) has not yet been conducted for evaluating the safety and efficacy of EA or acupuncture for the treatment of CHHF. This study aims to evaluate the effects of EA in CHHF patients. Methods: This study is a randomized, multicenter, and parallel design clinical trial. Overall, 72 participants will be randomly assigned to the EA treatment group, acupuncture treatment group, and untreated control group in 1:1:1 ratio via a web-based randomization system. The EA treatment group and acupuncture treatment group will receive EA or acupuncture treatment by visiting ten times at intervals of twice a week for five weeks. Follow-up visits will be made four weeks after the end of treatment. For the untreated control group, three visits will be made. The primary outcome measures will be the CHHF visual analogue scale score. Secondary outcome measures will be the body temperature of hands and feet, total scores of the Korean version of the World Health Organization Quality of Life Scale abbreviated version, the results of the questionnaire of health-related quality of life, questionnaire of demonstration, and questionnaire of cold hypersensitivity.Discussion: This study will be the first clinical trial to evaluate the efficacy and safety of EA for the treatment of CHHF. We expect this study to provide basic evidence for the treatment of CHHF with EA, future large-scale RCT, and the development of general clinical guidelines for CHHF in the Korean medical field.Trial registration: CRIS, KCT0004306. Registered on October 14, 2019. https://cris.nih.go.kr/cris/search/search_result_st01.jsp?seq=14865

scholarly journals The efficacy of chloroquine treatment against naturally occuring Giardia duodenalis infection in lambs

2016 ◽  
pp. 5328-5335
Author(s):  
Umit Karademir ◽  
Kerem Ural ◽  
Nuran Aysul ◽  
Adnan Ayan ◽  
Songul Toplu ◽  
...  
Keyword(s):  
Placebo Group ◽  
Treatment Group ◽  
Untreated Control ◽  
Giardia Duodenalis ◽  
Control Group ◽  
Untreated Control Group ◽  
Effective Treatment Option ◽  
Chloroquine Treatment ◽  
Los Grupos ◽  
Very High

Objective. The aim of the present study was to determine the efficacy of Chloroquine (Cq), an antimalarial medicine, administered at a dose of 2.5 mg/kg, orally, during 5 consecutive days, in Sakiz and Merino lambs naturally infected with Giardia duodenalis. Materials and methods. To this extent weaned 10 weeks of aged lambs were enrolled and randomly assigned into two groups based on treatment (group C, n=18 lambs treated with Cq) and placebo (group P, n=8 untreated control animals). Diagnosis was based on detection of trophozoit and/or cysts on fecal flotation. Cyst count per gram feces (days 0, 3, 7 and 10) was analyzed among groups. Results. During the trial, regarding the efficacy of Cq on days 3., 7., and 10. There was significant (p<0.01) reduction in cyst excretion; whereas evaluation of mean geometric cyst excretion revealed 100% reduction. Conclusions. There was a very high (100%) reduction in cyst excretion in the Cq treatment group compared to the positive untreated control group on days 3, 7 and 10, resulting in a significant (p<0.001) reduction, making Cq, safety, and thus highly effective treatment option of lambs with naturally occuring giardiasis.Objetivo. El objetivo del presente estudio fue determinar la eficacia de la cloroquina, un medicamento contra la malaria, administrado a una dosis de 2.5 mg/kg, por vía oral, durante 5 días consecutivos, en Corderos Sakiz y Merino infectados naturalmente con Giardia duodenalis. Materiales y metodos. En esta medida destetados 10 semanas de edad fueron incluidos y asignados al azar en dos grupos sobre la base del tratamiento (grupo C, n = 18 corderos tratados con cloroquina) y placebo (grupo P, n = 8 animales de control no tratados). El diagnóstico se basa en la detección de trophozoit y/o quistes en la flotación fecal. Quiste recuento por gramo de heces (día 0, 3, 7 y 10) se analizó entre los grupos. Resultados. Respecto a la eficacia de la cloroquina en los días 3, 7 y 10 existió una reducción significativa (p<0.01) en la excreción de quistes; mientras que la evaluación de la media de la excreción Rev.MVZ Córdoba 21(2):5328-5335, 2016. ISSN: 0122-0268 ORIGINAL 5329 de quistes reveló una reducción del 100%. Conclusiones. Durante el estudio hubo una reducción del 100% en la excreción de quistes en el grupo de tratamiento con cloroquina en comparación con el grupo control no tratado positivo en los días 3, 7 y 10, lo que resulta en una disminución significativa (p<0.001) por lo que la cloroquina razonablemente es una opción de tratamiento por el costo, seguridad, y por lo tanto muy eficaz de corderos infectados naturalmente con giardiasis.

scholarly journals Efficacy of a New Non-drug Acne Therapy: Aloe Vera Gel Combined With Ultrasound and Soft Mask for the Treatment of Mild to Severe Facial Acne

2021 ◽  
Vol 8 ◽  
Author(s):  
Hongyu Zhong ◽  
Xiang Li ◽  
Wanqi Zhang ◽  
Xiaoxiao Shen ◽  
Yuangang Lu ◽  
...  
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Combined Therapy ◽  
Aloe Vera ◽  
Physical Method ◽  
Control Group ◽  
Severe Acne ◽  
Aloe Vera Gel ◽  
Before And After ◽  
Acne Therapy

Background: Acne is a chronic disorder that affects almost 80% of adolescents and young adults, causing psychological and emotional distress. However, the current treatments for acne are either ineffective or have many side effects. This study was designed to confirm and objectively quantify the effect of a new non-drug combined therapy on acne.Methods: This study innovatively utilized ultrasound, which enhanced the absorption of aloe vera gel, and soft mask to make a purely physical method without any drugs. In both the treatment group and control group, the number of papules/pustules and the area of hyperpigmented lesions were counted, and a smart mirror intelligent face system was used before and after the combined therapy. Alterations in the skin functional index were recorded and analyzed statistically.Results: In the treatment group, the combined therapy significantly reduced the number of papules and the area of hyperpigmented lesions and improved skin roughness and local blood circulation. In the control group, there was no obvious improvement over 2 months.Conclusion: This study suggests that the new non-drug combined therapy significantly improved acne, which provided experimental evidence and treatment guidance for patients with mild to severe acne, especially patients with moderate acne. This new therapy may possibly be an appropriate method for patients who seek topical treatments with mild side effects and low antibiotic resistance rates.

scholarly journals Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247662
Author(s):  
Jingjing He ◽  
Desheng Kong ◽  
Zhifen Yang ◽  
Ruiyun Guo ◽  
Asiamah Ernest Amponsah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Treatment Group ◽  
Random Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Control Group ◽  
Efficacy And Safety ◽  
Significant Difference

Background Diabetes mellitus as a chronic metabolic disease is threatening human health seriously. Although numerous clinical trials have been registered for the treatment of diabetes with stem cells, no articles have been published to summarize the efficacy and safety of mesenchymal stem cells (MSCs) in randomized controlled trials (RCTs). Methods and findings The aim of this study was to systematically review the evidence from RCTs and, where possible, conduct meta-analyses to provide a reliable numerical summary and the most comprehensive assessment of therapeutic efficacy and safety with MSCs in diabetes. PubMed, Web of Science, Ovid, the Cochrane Library and CNKI were searched. The retrieval time was from establishment of these databases to January 4, 2020. Seven RCTs were eligible for analysis, including 413 participants. Meta-analysis results showed that there were no significant differences in the reduction of fasting plasma glucose (FPG) compared to the baseline [mean difference (MD) = -1.05, 95% confidence interval (CI) (-2.26,0.16), P<0.01, I2 = 94%] and the control group [MD = -0.62, 95%CI (-1.46,0.23), P<0.01, I2 = 87%]. The MSCs treatment group showed a significant decrease in hemoglobin (Hb) A1c [random-effects, MD = -1.32, 95%CI (-2.06, -0.57), P<0.01, I2 = 90%] after treatment. Additionally, HbA1c reduced more significantly in MSC treatment group than in control group [random-effects, MD = -0.87, 95%CI (-1.53, -0.22), P<0.01, I2 = 82%] at the end of follow-up. However, as for fasting C-peptide levels, the estimated pooled MD showed that there was no significant increase [MD = -0.07, 95%CI (-0.30, 0.16), P<0.01, I2 = 94%] in MSCs treatment group compared with that in control group. Notably, there was no significant difference in the incidence of adverse events between MSCs treatment group and control group [relative risk (RR) = 0.98, 95%CI (0.72, 1.32), P = 0.02, I2 = 70%]. The most commonly observed adverse reaction in the MSC treatment group was hypoglycemia (29.95%). Conclusions This meta-analysis revealed MSCs therapy may be an effective and safe intervention in subjects with diabetes. However, due to the limited studies, a number of high-quality as well as large-scale RCTs should be performed to confirm these conclusions.

scholarly journals Intervensi Berbasis Mindfulness untuk Menurunkan Stres pada Orang Tua

2019 ◽  
Vol 3 (1) ◽  
pp. 23
Author(s):  
Rahmantika Kurnia Romadhani ◽  
M. Noor Rochman Hadjam
Keyword(s):  
Experimental Design ◽  
Untreated Control ◽  
Statistical Test ◽  
Control Group ◽  
Untreated Control Group ◽  
Mindfulness Intervention ◽  
Quasi Experimental

The purpose of this research is to reduce parents’ stress by increasing their mindfulness ability using Mindfulness intervention. Participants in this study consisted of 15 mothers with stress from mild to severe. The design use in this study is quasi experimental design with untreated control group with pretest and postest. The program consists of 8 session intervention. The instruments used in this research are DASS Scale and KIMS scale. Quantitaive analysis was conducted through  statistical test using Mann-Whitney and also qualitative analysist. The result of this study showed that intervention with mindfulness was effective to reduce stress in parents (U=0,000; p<0,001).

scholarly journals Pelatihan “Great Mom Great Children” pada Ibu Muda Jalanan dalam Meningkatkan Ketrampilan Stimulasi Perkembangan Anak

2021 ◽  
Vol 6 (2) ◽  
pp. 1126-1134
Author(s):  
Dessy Pranungsari ◽  
Nissa Tarnoto ◽  
Fatwa Tentama
Keyword(s):  
Untreated Control ◽  
Control Group ◽  
Untreated Control Group ◽  
Control Group Design ◽  
Group Design

Anak jalanan perempuan yang memiliki anak di usia muda kurang memiliki pengetahuan dan ketrampilan dalam menstimulasi perkembangan anak. Tujuan dari penelitian ini adalah meningkatkan ketrampilan stimulasi perkembangan pada ibu-ibu muda jalanan dengan memberikan perlakuan berupa pelatihan “Great Mom Great Children”. Subjek dalam penelitian ini adalah ibu merupakan anak jalanan yang tinggal di Yogyakarta, ibu muda yang berusia kurang dari 18 tahun saat memiliki anak, ibu yang memiliki anak atas kehamilan yang tidak dikehendaki, ibu memiliki anak berusia 0-5 tahun (anak usia dini), dan ibu mengasuh anaknya sendiri secara langsung. Desain eksperimen yang digunakan adalah untreated control group design with dependent pretest and posttest samples. Alat pengumpulan data menggunakan Kuisioner Pra Skrinning Perkembangan (KPSP). Hasil Uji Wilcoxon untuk menguji perbedaan tingkat ketrampilan stimulasi ibu-ibu muda jalanan antara sebelum (pretest) dan sesudah diberi perlakuan (posttest) menunjukkan adanya perbedaan yang signifikan anatara skor pretest dan postest. Hasil Uji Mann Whitney U-test diperoleh hasil rata-rata tingkat ketrampilan stimulasi kelompok eksperimen lebih tinggi daripada kelompok kontrol. Hal ini menunjukkan bahwa metode pelatihan “Great Mom Great Children” efektif dalam meningkatkan ketrampilan stimulasi perkembangan anak pada ibu-ibu muda jalanan.

PLACEBO VS NONTREATMENT

PEDIATRICS ◽  
1996 ◽  
Vol 98 (6) ◽  
pp. 1178-1178
Author(s):  
Student
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Placebo Effect ◽  
Untreated Control ◽  
Control Group ◽  
Untreated Control Group ◽  
Nonspecific Effects

We often and wrongly equate the response seen in the placebo arm of a clinical trial with the placebo effect. In order to obtain the true placebo effect, other nonspecific effects can be identified by including an untreated control group in clinical trials.

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