Determination of Inheritance of Single Congenital Portosystemic Shunts in Yorkshire Terriers

2003 ◽  
Vol 39 (4) ◽  
pp. 385-389 ◽  
Author(s):  
Karen M. Tobias
Keyword(s):  
Odds Ratio ◽  
Pedigree Analysis ◽  
Portosystemic Shunts ◽  
Coefficient Of Inbreeding ◽  
Common Ancestors

A hereditary basis for congenital portosystemic shunts (PSS) in Yorkshire terriers was explored through record and pedigree analysis and a breeding trial. The odds ratio for PSS in Yorkshire terriers was 35.9 times greater than for all other breeds combined. Wright’s coefficient of inbreeding was approximately twice as high for Yorkshire terriers with PSS as compared to normal members of the breed (P=0.09). No common ancestors were found that were significant to the PSS group. Two affected Yorkshire terriers were bred and produced two normal puppies. Congenital PSS appears to be hereditary in Yorkshire terriers; however, the mechanism of inheritance has yet to be elucidated.

scholarly journals Determination of the influence of predictors and the probability of retinal detachment in children based on the analysis of the odds ratio

Doklady BGUIR ◽  
2021 ◽  
Vol 19 (7) ◽  
pp. 106-109
Author(s):  
H. A. Sushchenia
Keyword(s):  
Retinal Detachment ◽  
Odds Ratio ◽  
Comparison Group ◽  
Significant Risk ◽  
Preventive Treatment ◽  
Risk Groups ◽  
Vitreoretinal Interface ◽  
Clinical Hospital

The analysis of the influence of predictors on the probability of retinal detachment in children of the Minsk region was carried out on the basis of a study of the medical records of 660 children's patients treated at the Health care Institutions "4th Children's City Clinical Hospital" and “Minsk Regional Children's Clinical Hospital” for the period 2009–2019. Of these, 313 patients were older than 1 year with an established diagnosis of retinal detachment, 107 children under the age of 1 year, 240 children older than 1 year without retinal detachment at the time of treatment and the presence of predictors of its development (comparison group). To assess the influence of factors, a methodology based on the calculation of the odds ratio was used. The most significant risk factors were assigned a score equivalent from one to four, which allowed quantifying the probability of retinal detachment and identifying risk groups depending on the total score. The use of the proposed method allowed the children of the comparison group to identify changes in the vitreoretinal interface, which required primary laser preventive treatment in 46.7% of cases (113 eyes) during the three-year follow-up period, in 45.4% of children (109 eyes) it was limited only to dynamic observation without treatment. In 95.0% of children in the comparison group, it was possible to prevent the development of retinal detachment.

Testing Models for Genetic Determination in Migraine

Cephalalgia ◽  
1993 ◽  
Vol 13 (6) ◽  
pp. 389-394 ◽  
Author(s):  
M Mochi ◽  
S Sangiorgi ◽  
P Cortelli ◽  
V Carelli ◽  
C Scapoli ◽  
...  
Keyword(s):  
Migraine Without Aura ◽  
Segregation Analysis ◽  
Autosomal Recessive ◽  
Phenotypic Expression ◽  
Pedigree Analysis ◽  
The Other ◽  
Genetic Determination ◽  
Reduced Penetrance ◽  
Matched Samples

We collected two clinically matched samples of patients, one sample affected by migraine with aura the other by migraine without aura, to investigate the genetic determination of these conditions. A maternal and X-linked transmission for both these diseases was considered unlikely after pedigree analysis. Classical segregation analysis indicated a likely autosomal recessive kind of transmission for both. Reduced penetrance and the h2 values, however, imply the presence of additional genetic and/or environmental factors controlling the phenotypic expression of migraine.

scholarly journals Prevalence of Phenylthiocarbamide (PTC) Taste Sensitivity and Colour Blindness in Tengger Tribe Population, Ranupani Village, Senduro, Lumajang

2021 ◽  
Vol 9 (4) ◽  
pp. 174
Author(s):  
Rike Oktarianti ◽  
Iguh Widigda Putra ◽  
Resmining Mega Arofa ◽  
Asmoro Lelono
Keyword(s):  
Allele Frequency ◽  
Autosomal Dominant ◽  
Color Blindness ◽  
Pedigree Analysis ◽  
Dominant Trait ◽  
Genetic Trait ◽  
Autosomal Dominant Trait ◽  
Colour Blindness ◽  
Color Blind

The taste of sensitivity of phenylthiocarbamide (PTC), is autosomal dominant trait inherited while the colour blindness is a sex linked genetic trait on the X chromosome. The purpose of this study was to determine the distribution of taster and non taster phenotypes, prevalence of color blindness, frequency of taster and non taster alleles, and frequency of color blind alleles, as well as pedigree analysis in non taster and color blind families. The research was conducted on the Tengger tribe, in Ranupani village, Senduro, Lumajang. Determination of the sample is carryout randomly. Detection of the ability to taste PTC was respondents to taste the PTC solution from the lowest concentration of 0.32mg/L (P13) to the highest concentration of 1300 mg/L (P1). Color blindness detection by the Ishihara method. The results of the study showed that the distribution of the taster was 98.1% while the non-taster was 1.9%. The allele frequency of the dominant taster (T) was 0.86 and the recessive allele non taster (t) is 0.14. The prevalence of color blindness in the population of the Tengger tribe was 0.63% and the allele frequency for color blindness was 0.013. The pedigree analysis of non taster family showed that non taster individuals were born from taster couple (Tt) or from couple of non taster (tt) with tasters (Tt) heterozigot. While the pattern of inheritance of color blindness was criss-cross inheritance pattern, which is passed from mother to son.

scholarly journals Association of polymorphism rs7903146 gene TCF7L2 with low concentrations of autoantibodies in latent autoimmune diabetes of adults (LADA)

2016 ◽  
Vol 19 (3) ◽  
pp. 199-203 ◽  
Author(s):  
Iuliia V. Silko ◽  
Tatiana V. Nikonova ◽  
Olga N. Ivanova ◽  
Svetlana M. Stepanova ◽  
Marina V. Shestakova ◽  
...  
Keyword(s):  
Odds Ratio ◽  
Autoimmune Diabetes ◽  
Polymorphic Marker ◽  
Healthy Individuals ◽  
Tcf7l2 Gene ◽  
Latent Autoimmune Diabetes ◽  
Low Concentrations ◽  
High Concentrations

Aim. To determine the frequencies of alleles and genotypes of polymorphic marker rs7903146 of the TCF7L2 gene in latent autoimmune diabetes in adults (LADA) and healthy individuals. The aims of the study were also to compare the distribution of alleles and genotypes and to explore the association with the development of LADA.Materials and methods. A total of 96 patients (46 females and 50 males) with LADA and 201 healthy individuals were examined. A quantitative determination of autoantibodies GADA, ICA, IA-2A and ZnT8 in the serum of LADA patients was performed. All patients underwent genotyping of rs7903146 of the TCF7L2 genes.Results. There was an increased frequency of the T allele and genotype T+ of marker rs7903146 of the TCF7L2 gene in patients with LADA with low concentrations of autoantibodies compared to a group of patients with high concentrations and with controls. We observed significant associations of the T allele and genotype T+ with LADA in patients with low concentrations of autoantibodies [p = 0.02; odds ratio (OR) = 1.85; 95% confidence interval (CI) = 1.10–3.13 and p = 0.04; OR = 2.14; 95% CI = 1.01–4.53 for the T allele and genotype T+, respectively).Conclusion. The results of the study suggest that LADA patients with low concentrations of autoantibodies have a genetically pre-determined similarity with patients with type 2 diabetes.

Prevalence of Physical Inactivity and Associated Factors Among Older Caregivers of Older Adults

2018 ◽  
Vol 31 (5) ◽  
pp. 793-813 ◽  
Author(s):  
Grace Angélica de Oliveira Gomes ◽  
Bruna Moretti Luchesi ◽  
Aline Cristina Martins Gratão ◽  
Fabiana de Souza Orlandi ◽  
Karina Gramani Say ◽  
...  
Keyword(s):  
Older Adults ◽  
Odds Ratio ◽  
Physical Inactivity ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Independent Variables ◽  
Older Caregivers

Objective: The aim of this study is to analyze the prevalence of physical inactivity (PI) and associated factors in older caregivers of older adults. Method: A cross-sectional study was conducted including 312 older caregivers. Sociodemographic, clinical, and care-related characteristics were considered the independent variables for the determination of associated factors with PI in the logistic regression model. Results: The prevalence of PI was 75.3% (95% confidence interval [CI] = [70.1%, 80.0%]). The following factors were associated with PI: being female (odds ratio [OR] = 2.8, 95% CI = [1.3, 5.9]), being older than 75 years of age (OR = 7.1, 95% CI = [2.2, 22.9]), not having a marital life (OR = 4.2, 95% CI = [1.1, 15.8]), being prefrail (OR = 6.2, 95% CI = [1.7, 21.9]), and being frail (OR = 14.8, 95% CI = [3.8, 57.7]). Discussion: The prevalence of PI was high and associated with the female sex, an advanced age, and not being married. Specific public policies considering these results should be created for older caregivers.

scholarly journals Analysis of the relationship between coefficients of relatedness and molecular similarity of parental forms with respect to the heterosis effect in maize

2013 ◽  
Vol 50 (1) ◽  
pp. 39-52
Author(s):  
Agnieszka Tomkowiak ◽  
Zbigniew Broda ◽  
Krzysztof Moliński ◽  
Marta Molińska-Glura ◽  
Józef Adamczyk
Keyword(s):  
Molecular Markers ◽  
Molecular Similarity ◽  
Pedigree Analysis ◽  
Molecular Techniques ◽  
Pedigree Information ◽  
Genetic Purity ◽  
Heterotic Groups ◽  
Heterosis Effect ◽  
Selection Of

SUMMARY Within the last twenty years studies have been conducted at many research centers with the aim of dividing breeding materials into heterotic groups based on molecular markers. Molecular techniques make it possible to study the genetic purity of inbred lines, determine their genetic variability and classify breeding materials for which no information is available on their origin. This study aims to investigate relationships between coefficients of relatedness (pedigree analysis) and molecular similarity estimated on the basis of AFLP and RAPD molecular markers, between parental forms of F1 maize hybrids. Determination of these relationships will make it possible to establish a hierarchy of importance for applied methods concerning selection of parental components for heterotic crossings based on the degree of relatedness and genetic similarity. As a result of the experiment it was shown that in the case of incomplete pedigree information, in the selection of parental components for crossings we may use information concerning molecular similarity determined using AFLP markers and the Jaccard index, which to the least degree differentiates matrices of AFLP and RAPD molecular similarity.

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