Role of human leukocyte antigen-G 14-base pair polymorphism in kidney transplantation outcomes

2013 ◽  
Vol 26 (6) ◽  
pp. 1170-1178 ◽  
Author(s):  
Roberto Littera ◽  
Gianbenedetto Piredda ◽  
Antonello Pani ◽  
Mauro Frongia ◽  
Bruno Onano ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Human Leukocyte Antigen ◽  
Base Pair ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
Transplantation Outcomes ◽  
G 14

scholarly journals The Many Faces of Human Leukocyte Antigen-G: Relevance to the Fate of Pregnancy

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Mette Dahl ◽  
Snezana Djurisic ◽  
Thomas Vauvert F. Hviid
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Future Research ◽  
Placental Development ◽  
Leukocyte Antigen ◽  
Polymorphic Genes ◽  
Membrane Bound ◽  
The Many ◽  
Human Leukocyte Antigen G

Pregnancy is an immunological paradox, where fetal antigens encoded by polymorphic genes inherited from the father do not provoke a maternal immune response. The fetus is not rejected as it would be theorized according to principles of tissue transplantation. A major contribution to fetal tolerance is the human leukocyte antigen (HLA)-G, a nonclassical HLA protein displaying limited polymorphism, restricted tissue distribution, and a unique alternative splice pattern. HLA-G is primarily expressed in placenta and plays multifaceted roles during pregnancy, both as a soluble and a membrane-bound molecule. Its immunomodulatory functions involve interactions with different immune cells and possibly regulation of cell migration during placental development. Recent findings include HLA-G contributions from the father and the fetus itself. Much effort has been put into clarifying the role of HLA-G during pregnancy and pregnancy complications, such as preeclampsia, recurrent spontaneous abortions, and subfertility or infertility. This review aims to clarify the multifunctional role of HLA-G in pregnancy-related disorders by focusing on genetic variation, differences in mRNA stability betweenHLA-Galleles, differences in HLA-G isoform expression, and possible differences in functional activity. Furthermore, we highlight important observations regardingHLA-Ggenetics and expression in preeclampsia that future research should address.

Association of human leukocyte antigen-G 14 bp polymorphism with recurrent pregnancy loss in European countries: a meta-analysis of literature studies

2019 ◽  
Vol 112 (3) ◽  
pp. 577-585.e3 ◽  
Author(s):  
Marcello Monti ◽  
Roberta Lupoli ◽  
Loredana Maria Sosa Fernandez ◽  
Ferdinando Cirillo ◽  
Matteo Nicola Dario Di Minno
Keyword(s):  
Human Leukocyte Antigen ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
European Countries ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
G 14

Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells

2009 ◽  
Vol 70 (12) ◽  
pp. 966-969 ◽  
Author(s):  
Silvia Gregori ◽  
Chiara Francesca Magnani ◽  
Maria-Grazia Roncarolo
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G

Potential role of soluble human leukocyte antigen-G molecules in multiple sclerosis

2009 ◽  
Vol 70 (12) ◽  
pp. 981-987 ◽  
Author(s):  
Enrico Fainardi ◽  
Roberta Rizzo ◽  
Massimiliano Castellazzi ◽  
Marina Stignani ◽  
Enrico Granieri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Human Leukocyte Antigen ◽  
Potential Role ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G
Sign in / Sign up

Export Citation Format

Share Document