scholarly journals Meta-analysis of the human leukocyte antigen-G (HLA-G) 14 bp insertion/deletion polymorphism as a risk factor for preeclampsia

2015 ◽  
Vol 86 (3) ◽  
pp. 186-194 ◽  
Author(s):  
N. Pabalan ◽  
H. Jarjanazi ◽  
C. Sun ◽  
A. C. Iversen
Keyword(s):  
Risk Factor ◽  
Human Leukocyte Antigen ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Deletion Polymorphism ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
G 14

Association of human leukocyte antigen-G 14 bp polymorphism with recurrent pregnancy loss in European countries: a meta-analysis of literature studies

2019 ◽  
Vol 112 (3) ◽  
pp. 577-585.e3 ◽  
Author(s):  
Marcello Monti ◽  
Roberta Lupoli ◽  
Loredana Maria Sosa Fernandez ◽  
Ferdinando Cirillo ◽  
Matteo Nicola Dario Di Minno
Keyword(s):  
Human Leukocyte Antigen ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
European Countries ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
G 14

Role of human leukocyte antigen-G 14-base pair polymorphism in kidney transplantation outcomes

2013 ◽  
Vol 26 (6) ◽  
pp. 1170-1178 ◽  
Author(s):  
Roberto Littera ◽  
Gianbenedetto Piredda ◽  
Antonello Pani ◽  
Mauro Frongia ◽  
Bruno Onano ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Human Leukocyte Antigen ◽  
Base Pair ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
Transplantation Outcomes ◽  
G 14

scholarly journals Prognostic and Clinicopathological Value of Human Leukocyte Antigen G in Gastrointestinal Cancers: A Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Yongjia Peng ◽  
Jian Xiao ◽  
Wenyun Li ◽  
Shuna Li ◽  
Binbin Xie ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Histological Grade ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Cochrane Library ◽  
Clinicopathological Parameters ◽  
Cancer Type ◽  
Leukocyte Antigen ◽  
Gi Cancers ◽  
Human Leukocyte Antigen G

BackgroundThe prognostic value of human leukocyte antigen G (HLA-G) expression in gastrointestinal (GI) cancers remains controversial. Thus, this meta-analysis aimed to summarize available evidence from case-control or cohort studies that evaluated this association.MethodsThe PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched to identify relevant studies written in English published up to April 1, 2021, and with no initial date. Furthermore, the Google Scholar and Google databases were also searched manually for gray literature. The protocol for this meta-analysis was registered at PROSPERO (CRD42020213411). Pooled hazard ratios (HRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for end points using fixed- and random-effects statistical models to account for heterogeneity. Publication bias was evaluated using a funnel plot, Begg’s and Egger’s tests, and the “trim and fill” method.ResultsA total of 30 eligible articles with 5737 unique patients, including 12 studies on colorectal cancer (CRC), 6 on gastric cancer (GC), 5 on esophageal cancer (ESCC), 5 on hepatocellular carcinoma (HCC), and 2 on pancreatic adenocarcinoma (PC), were retrieved. Both univariate (HR = 2.01, 95% CI: 1.48 ~ 2.72) and multivariate (HR = 2.69, 95% CI: 2.03 ~ 3.55) analyses revealed that HLA-G expression was significantly correlated with poor overall survival (OS), regardless of the cancer type or antibody used. Subgroup analysis stratified by antibody showed that the 4H84 (I2 = 45.8%, P = 0.101) antibodies could be trustworthy and reliable for detecting HLA-G expression in GI cancers. In addition, HLA-G expression was found to be correlated with adverse clinicopathological parameters such as clinical stage, nodal status, metastasis, and histological grade but not tumor status.ConclusionElevated HLA-G expression indicates a poor prognosis for GI cancer patients, and screening for this marker could allow for the early diagnosis and treatment of GI cancers to improve survival rates.

scholarly journals Elevation of plasma-soluble HLA-G in childhood nephrotic syndrome is associated with IgE

2016 ◽  
Vol 54 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Yanqing Liu ◽  
Meimei Lai ◽  
Yunyan Lou ◽  
Qiuyue Han ◽  
Qing Yang ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Human Leukocyte Antigen ◽  
Base Pair ◽  
Immunoglobulin E ◽  
Human Leukocyte ◽  
Deletion Polymorphism ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
Normal Controls ◽  
Base Pair Insertion

Background Nephrotic syndrome is related to immune system dysfunction. Soluble human leukocyte antigen-G has been suggested to have an immunomodulatory role. Additionally, human leukocyte antigen-G expression may be influenced by the 14-base pair insertion/deletion polymorphism. However, this molecule has not been investigated in nephrotic syndrome. Methods Fifty-five children with nephrotic syndrome were enrolled: 24 primary nephrotic syndrome patients and 31 recurrent nephrotic syndrome patients. A group of 120 healthy subjects were included as reference controls. Additionally, 22 patients in nephrotic syndrome remission after treatments were also included. Both nephrotic syndrome patients and healthy subjects were genotyped for the 14-base pair insertion/deletion polymorphism. Plasma soluble human leukocyte antigen-G concentrations and serum immunoglobulin concentrations were determined. Results Nephrotic syndrome patients showed significantly higher levels of both soluble human leukocyte antigen-G and immunoglobulin E compared to normal controls. Nephrotic syndrome patients presented a higher frequency of the −14-base pair allele than did normal controls. Soluble human leukocyte antigen-G concentrations in remission patients were dramatically lower compared to in nephrotic syndrome patients. Moreover, soluble human leukocyte antigen-G and immunoglobulin E were moderately correlated in nephrotic syndrome patients. Conclusions The present study demonstrated that plasma soluble human leukocyte antigen-G concentrations were significantly elevated and that a relationship between serum total immunoglobulin E in nephrotic syndrome patients and the human leukocyte antigen-G −14-base pair allele may be a risk factor for nephrotic syndrome. These findings suggest that soluble human leukocyte antigen-G may be used as a monitoring marker for nephrotic syndrome patients' condition.

A meta-analysis of the impact of human leukocyte antigen-G on the outcomes of IVF/ICSI

2017 ◽  
Vol 34 (6) ◽  
pp. 611-618 ◽  
Author(s):  
Ziru Niu ◽  
Liangyi Wang ◽  
Ronald T.K. Pang ◽  
Yifan Guo ◽  
William S.B. Yeung ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Meta Analysis ◽  
Human Leukocyte ◽  
Leukocyte Antigen ◽  
Human Leukocyte Antigen G ◽  
The Impact

scholarly journals Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis

2021 ◽  
Author(s):  
Chonlaphat Sukasem ◽  
Suthida Sririttha ◽  
Chonlawat Chaichan ◽  
Thapanat Nakkrut ◽  
Patompong Satapornpong ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Antiepileptic Drugs ◽  
Meta Analysis ◽  
Strong Association ◽  
Human Leukocyte ◽  
Stevens Johnson Syndrome ◽  
Thai Population ◽  
Leukocyte Antigen ◽  
Maculopapular Eruption ◽  
Sequence Specific Oligonucleotide Probe

AbstractAromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs) add up to the limited use of the AEDs in the treatment and prevention of seizures. Human leukocyte antigen-B (HLA-B) alleles have been linked to AEDs-induced cADRs. We investigated the association between cADRs (including Stevens–Johnson syndrome; SJS/toxic epidermal necrolysis; TEN, drug reaction with eosinophilia and systemic symptoms; DRESS, and Maculopapular eruption; MPE) caused by AEDs (phenytoin, carbamazepine, lamotrigine, phenobarbital and oxcarbazepine) and HLA-B alleles in Thai population. Through the case-control study, 166 patients with AEDs-induced cADRs, 426 AEDs-tolerant patients (AEDs-tolerant controls), and 470 healthy subjects (Thai population) were collected. The HLA genotypes were detected using the polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. We also performed a meta-analysis with these data and other populations. The carrier rate of HLA-B*15:02 was significantly different between AEDs-induced cADRs group and AEDs-tolerant group (Odds ratio; OR 4.28, 95% Confidence interval; CI 2.64–6.95, p < 0.001), AEDs-induced cADRs group and Thai population (OR 2.15, 95%CI 1.41–3.29, p < 0.001). In meta-analysis showed the strong association HLA-B*15:02 with AEDs-induced cADRs (OR 4.77, 95%CI 1.79–12.73, p < 0.001). Furthermore, HLA-B*15:02 was associated with SJS/TEN induced by AEDs (OR 10.28, 95%CI 6.50–16.28, p < 0.001) Phenytoin (OR 4.12, 95%CI 1.77–9.59, p = 0.001) and carbamazepine (OR 137.69, 95%CI 50.97–371.98, p < 0.001). This study demonstrated that genetic association for AEDs-induced cADRs was phenotype-specific. A strong association between HLA-B*15:02 and AEDs-induced SJS/TEN was demonstrated with an OR of 10.79 (95%CI 5.50–21.16, p < 0.001) when compared with AEDs-tolerant group. On the other hand, the carrier rates of HLA-B*08:01, HLA-B*13:01, and HLA-B*56:02 were significantly higher in the DRESS group compared with the AEDs-tolerant group (p = 0.029, 0.007, and 0.017, respectively). The HLA-B*15:02 allele may represent a risk factor for AEDs-induced cADRs.

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