Clinical significance of preoperative serum sialic acid levels in colorectal cancer: utility in the detection of patients at high risk of tumor recurrence

2004 ◽  
Vol 19 (1) ◽  
pp. 38-45 ◽  
Author(s):  
C. Feijoo-Carnero ◽  
F.J. Rodrguez-Berrocal ◽  
M. Pez de la Cadena ◽  
D. Ayude ◽  
A. de Carlos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Sialic Acid ◽  
High Risk ◽  
Clinical Significance ◽  
Tumor Recurrence ◽  
Preoperative Serum ◽  
Serum Sialic Acid

Clinical Significance of Preoperative Serum Sialic Acid Levels in Colorectal Cancer: Utility in the Detection of Patients at High Risk of Tumor Recurrence

2004 ◽  
Vol 19 (1) ◽  
pp. 38-45 ◽  
Author(s):  
C. Feijoo-Carnero ◽  
F.J. Rodríguez-Berrocal ◽  
M. Pez de la Cadena ◽  
D. Ayude ◽  
A. de Carlos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Analysis ◽  
Sialic Acid ◽  
High Risk ◽  
Tumor Recurrence ◽  
Early Stage ◽  
Thiobarbituric Acid ◽  
Preoperative Serum ◽  
Serum Sialic Acid ◽  
The Impact

This study was conducted to evaluate the significance of preoperative serum sialic acid levels in the diagnosis and prognosis of colorectal cancer (CRC). Total sialic acid (TSA) was determined by the thiobarbituric acid method and normalized to total protein (TP). A postoperative follow-up of CRC patients classified as Dukes’ stages A, B or C was performed and survival analysis was carried out to evaluate the impact of sialic acid levels on tumor recurrence. Our diagnostic studies indicate that TSA/TP is a better marker than either TSA or carcinoembryonic antigen (CEA), especially for the detection of CRC patients at an early stage. At a cutoff of 30.90 nmol/mg of protein, TSA/TP showed a sensitivity of 85% with a specificity of 97% to discriminate CRC patients from healthy donors. In survival analysis, both TSA and TSA/TP were found to be significant prognostic factors for tumor recurrence in CRC. Furthermore, TSA/TP could distinguish patients at high risk of recurrence within Dukes’ stage B and in multivariate analysis it was identified as the best independent prognostic factor. According to our results, preoperative serum TSA/TP content could supply additional information to that provided by Dukes’ stage about the prognosis of CRC patients.

Evaluation of serum sialic acid and carcinoembryonic antigen for the detection of early-stage colorectal cancer

1991 ◽  
Vol 5 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Carmen Tautu ◽  
Jack A. Alhadeff ◽  
David Pee ◽  
Marlene Dunsmore ◽  
Joseph J. Prorok
Keyword(s):  
Colorectal Cancer ◽  
Sialic Acid ◽  
Carcinoembryonic Antigen ◽  
Early Stage ◽  
Serum Sialic Acid

Comprehensive analysis of predictive biomarkers for patients with curative colorectal cancer patients and high risk of recurrence.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 607-607 ◽  
Author(s):  
Koichiro Mori ◽  
Yuji Toiyama ◽  
Susumu Saigusa ◽  
Tomofumi Noguchi ◽  
Shozo Ide ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cells ◽  
High Risk ◽  
Predictive Factors ◽  
Univariate Analysis ◽  
Mononucleotide Repeat ◽  
Lymphocyte Ratio ◽  
Preoperative Serum ◽  
Molecular Phenotypes ◽  
The Impact

607 Background: Preoperative serum systemic inflammatory response (SIR) has been reported in patients with various cancers including colorectal cancer (CRC) as predictive biomarker of early recurrence. Molecular phenotypes of CRC including microsatellite instability (MSI) status and tumor infiltrating lymphocytes (TILs) have also known to be associated with recurrence in curative CRC patients. We comprehensively evaluated SIR status, MSI status and TILs in curative CRC patients and investigated which can be promising as high risk markers of recurrence in these patients. Methods: This retrospective study enrolled 157 CRC patients with stage I-III undergoing curative operation for whom preoperative neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and CRP were available as indicators of SIR status. For analysis of molecular phenotypes, we evaluated TILs by counting the number of intra-tumor Foxp3 and CD8 positive T cells by IHC analysis. Next, MSI status was determined in using 5 mononucleotide repeat microsatellite markers. Finally, we investigated the impact of SIR status, TILs and MSI status on the recurrence of these patients. Results: This study included a total of 90 males and 67 females, with an average age of 66.9 years. Twenty-nine patients (18.4%) developed recurrence. Kaplan-Meier analysis using SIR indicators revealed that patients with high CRP, NLR and PLR levels were significantly poorer disease free survival (DFS) than those with low levels. Low infiltrating CD8-positive T cells were significantly predictive factors for poor DFS, but there was no correlation between MSI status and recurrence, In univariate analysis, low infiltrating CD8-positive T cells, high CEA, CRP, NLR and PLR levels in serum were significantly predictive factors for poor DFS, respectively. Multivariate analysis showed that low infiltrating CD8-positive T cells and high serum CRP levels were independent predictive markers for recurrence in curative CRC patients. Conclusions: We demonstrated that evaluation of both CRP levels in preoperative serum and tumor infiltrating CD8 lymphocytes in CRC tissues are useful to predict the curative CRC patients with early relapse.

scholarly journals CLINICAL SIGNIFICANCE OF SERUM SIALIC ACID MEASUREMENT IN GASTRIC CANCER

1990 ◽  
Vol 51 (2) ◽  
pp. 251-255
Author(s):  
Akihiko WATANABE ◽  
Katsunori NAKATANI ◽  
Hidetomo SAWADA ◽  
Takashi NISHIWADA ◽  
Tohru OKUMURA ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Sialic Acid ◽  
Clinical Significance ◽  
Serum Sialic Acid

Clinical significance of preoperative serum vascular endothelial growth factor levels in patients with colorectal cancer and the effect of tumor surgery

Surgery ◽  
2002 ◽  
Vol 131 (5) ◽  
pp. 548-555 ◽  
Author(s):  
Anastasios J. Karayiannakis ◽  
Konstantinos N. Syrigos ◽  
Andrew Zbar ◽  
Nicolaos Baibas ◽  
Alexandros Polychronidis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Clinical Significance ◽  
Vascular Endothelial ◽  
Tumor Surgery ◽  
Preoperative Serum ◽  
Endothelial Growth Factor

Identifying Stage B colorectal cancer patients at high risk of tumor recurrence and death

1997 ◽  
Vol 40 (3) ◽  
pp. 326-331 ◽  
Author(s):  
Hugh E. Mulcahy ◽  
Mary Toner ◽  
Stephen E. Patchett ◽  
Leslie Daly ◽  
Diarmuid P. OʼDonoghue
Keyword(s):  
Colorectal Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Tumor Recurrence ◽  
Colorectal Cancer Patients

Serum sialic acid and carcinoembryonic levels in the detection and monitoring of colorectal cancer

1990 ◽  
Vol 33 (2) ◽  
pp. 139-142 ◽  
Author(s):  
Gary Verazin ◽  
Michael W. Riley ◽  
John Gregory ◽  
Carmen Tautu ◽  
Joseph J. Prorok ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Sialic Acid ◽  
Serum Sialic Acid
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