Serum sialic acid and carcinoembryonic levels in the detection and monitoring of colorectal cancer

1990 ◽  
Vol 33 (2) ◽  
pp. 139-142 ◽  
Author(s):  
Gary Verazin ◽  
Michael W. Riley ◽  
John Gregory ◽  
Carmen Tautu ◽  
Joseph J. Prorok ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Sialic Acid ◽  
Serum Sialic Acid

Clinical Significance of Preoperative Serum Sialic Acid Levels in Colorectal Cancer: Utility in the Detection of Patients at High Risk of Tumor Recurrence

2004 ◽  
Vol 19 (1) ◽  
pp. 38-45 ◽  
Author(s):  
C. Feijoo-Carnero ◽  
F.J. Rodríguez-Berrocal ◽  
M. Pez de la Cadena ◽  
D. Ayude ◽  
A. de Carlos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Analysis ◽  
Sialic Acid ◽  
High Risk ◽  
Tumor Recurrence ◽  
Early Stage ◽  
Thiobarbituric Acid ◽  
Preoperative Serum ◽  
Serum Sialic Acid ◽  
The Impact

This study was conducted to evaluate the significance of preoperative serum sialic acid levels in the diagnosis and prognosis of colorectal cancer (CRC). Total sialic acid (TSA) was determined by the thiobarbituric acid method and normalized to total protein (TP). A postoperative follow-up of CRC patients classified as Dukes’ stages A, B or C was performed and survival analysis was carried out to evaluate the impact of sialic acid levels on tumor recurrence. Our diagnostic studies indicate that TSA/TP is a better marker than either TSA or carcinoembryonic antigen (CEA), especially for the detection of CRC patients at an early stage. At a cutoff of 30.90 nmol/mg of protein, TSA/TP showed a sensitivity of 85% with a specificity of 97% to discriminate CRC patients from healthy donors. In survival analysis, both TSA and TSA/TP were found to be significant prognostic factors for tumor recurrence in CRC. Furthermore, TSA/TP could distinguish patients at high risk of recurrence within Dukes’ stage B and in multivariate analysis it was identified as the best independent prognostic factor. According to our results, preoperative serum TSA/TP content could supply additional information to that provided by Dukes’ stage about the prognosis of CRC patients.

Evaluation of serum sialic acid and carcinoembryonic antigen for the detection of early-stage colorectal cancer

1991 ◽  
Vol 5 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Carmen Tautu ◽  
Jack A. Alhadeff ◽  
David Pee ◽  
Marlene Dunsmore ◽  
Joseph J. Prorok
Keyword(s):  
Colorectal Cancer ◽  
Sialic Acid ◽  
Carcinoembryonic Antigen ◽  
Early Stage ◽  
Serum Sialic Acid

scholarly journals A comparison of the effect of glitazones on serum sialic acid in patients with type 2 diabetes

2011 ◽  
Vol 9 (3) ◽  
pp. 238-240 ◽  
Author(s):  
Inayat ur Rahman ◽  
Muhammad Idrees ◽  
Mohammad Salman ◽  
Rooh Ullah Khan ◽  
MI Khan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Sialic Acid ◽  
Treated Group ◽  
Diabetes Therapy ◽  
Beneficial Effects ◽  
Hba1 C ◽  
Serum Sialic Acid ◽  
High Incidence ◽  
Cv Disease

Although management of hyperglycaemia represents one of the principal treatment goals of diabetes therapy, the high incidence of cardiovascular (CV) complications in diabetes also needs effective management. Therefore, the present study was designed to determine and compare the effect of glitazones on serum sialic acid (SSA), a known risk marker for CV disease, along with fasting plasma glucose (FPG), glycohaemoglobin (HbA1-c) and blood lipids, in overweight, previously only diet-treated patients with type 2 diabetes ( n=60). The study was conducted for a period of 12 months. Significant improvement in FPG and HbA1-c were shown by both rosiglitazone ( p<0.003 and p<0.001, respectively) and pioglitazone ( p<0.005 and p<0.001, respectively), compared with baseline, and pioglitazone showed greater beneficial effects on other parameters monitored, significantly reducing total cholesterol (TC) ( p≤0.05). Both the drugs showed a decrease in SSA and no significant differences were observed between the groups. However, the decrease was significant only in the pioglitazone-treated group at month 12 ( p≤0.05), compared with baseline. A significant decrease in SSA by pioglitazone indicates its greater cardioprotective effect compared with rosiglitazone.

The influence of hemodialysis on serum sialic acid levels in chronic renal failure

2002 ◽  
Vol 6 (3) ◽  
pp. 154-157 ◽  
Author(s):  
E. Uslu ◽  
D. Güzey ◽  
H. Uzun ◽  
B. Kalender ◽  
O. Carikci
Keyword(s):  
Renal Failure ◽  
Sialic Acid ◽  
Chronic Renal Failure ◽  
Serum Sialic Acid

Relationship between serum sialic acid concentration and diabetic retinopathy in Egyptian patients with type 2 diabetes mellitus

2018 ◽  
Vol 35 (2) ◽  
pp. 257
Author(s):  
AhmedE Mansour ◽  
MohamedS El-Sayed ◽  
Ayman El Badawy ◽  
RashaO Abdelmoneim ◽  
MedhatEl-Moneim Khalil ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Sialic Acid ◽  
Acid Concentration ◽  
Serum Sialic Acid ◽  
Egyptian Patients

scholarly journals Assessment of serum sialic acid correlated with C3 in children with Mycoplasma pneumoniae pneumonia

2020 ◽  
Vol 34 (3) ◽  
Author(s):  
Yu‐Mei Mi ◽  
Qi Qi ◽  
Li Zhang ◽  
Xiao‐Fang Wang ◽  
Zhi‐Min Chen ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Mycoplasma Pneumoniae ◽  
Serum Sialic Acid ◽  
Mycoplasma Pneumoniae Pneumonia
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