Methylenetetrahydrofolate reductase genotype in diffuse large B-cell lymphomas with and without hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase

2003 ◽  
Vol 18 (3) ◽  
pp. 218-221 ◽  
Author(s):  
G. Toffoli ◽  
D. Rossi ◽  
G. Gaidano ◽  
E. Cecchin ◽  
M. Boiocchi ◽  
...  
Keyword(s):  
Dna Repair ◽  
B Cell ◽  
Dna Methyltransferase ◽  
Methylenetetrahydrofolate Reductase ◽  
B Cell Lymphomas ◽  
Repair Gene ◽  
Methylguanine Dna Methyltransferase ◽  
Dna Repair Gene ◽  
Large B Cell

Methylenetetrahydrofolate Reductase Genotype in Diffuse Large B-Cell Lymphomas with and without Hypermethylation of the DNA Repair Gene O6-Methylguanine DNA Methyltransferase

2003 ◽  
Vol 18 (3) ◽  
pp. 218-221 ◽  
Author(s):  
G. Toffoli ◽  
D. Rossi ◽  
G. Gaidano ◽  
E. Cecchin ◽  
M. Boiocchi ◽  
...  
Keyword(s):  
Dna Repair ◽  
B Cell ◽  
Dna Methyltransferase ◽  
Methylenetetrahydrofolate Reductase ◽  
B Cell Lymphomas ◽  
Repair Gene ◽  
Mthfr Polymorphisms ◽  
Methylguanine Dna Methyltransferase ◽  
Dna Repair Gene ◽  
Large B Cell

C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been suggested to affect susceptibility to malignant lymphoma, possibly by altering DNA methylation. The DNA repair gene O6-methylguanine DNA methyltransferase (MGMT) is transcriptionally silenced by promoter hypermethylation in diffuse large B-cell lymphomas (DLBCL). We analyzed the MTHFR677 and MTHFR1298 genotypes in 111 DLBCL patients and 465 controls. No significant difference in the frequency of MTHFR polymorphisms between patients and controls and no significant association between MTHFR677 or MTHFR1298 genotypes and methylation of MGMT promoter were observed. These results indicate that MTHFR variants are not related to DLBCL development and MGMT hypermethylation.

Prognostic significance of O6-methylguanine DNA methyltransferase and p57 methylation in patients with diffuse large B-cell lymphomas

Apmis ◽  
2009 ◽  
Vol 117 (2) ◽  
pp. 87-94 ◽  
Author(s):  
SUN MI LEE ◽  
EUI JIN LEE ◽  
YOUNG-HYEH KO ◽  
SUG HYUNG LEE ◽  
LEESO MAENG ◽  
...  
Keyword(s):  
B Cell ◽  
Dna Methyltransferase ◽  
Prognostic Significance ◽  
B Cell Lymphomas ◽  
Methylguanine Dna Methyltransferase ◽  
Large B Cell

High frequency and strong prognostic relevance of O6-methylguanine DNA methyltransferase silencing in diffuse large B-cell lymphomas from the Middle East

2006 ◽  
Vol 37 (6) ◽  
pp. 742-748 ◽  
Author(s):  
Khawla Al-Kuraya ◽  
Rajeswari Narayanappa ◽  
Abdul Khalid Siraj ◽  
Fouad Al-Dayel ◽  
Adnan Ezzat ◽  
...  
Keyword(s):  
Middle East ◽  
B Cell ◽  
High Frequency ◽  
Dna Methyltransferase ◽  
B Cell Lymphomas ◽  
Methylguanine Dna Methyltransferase ◽  
Prognostic Relevance ◽  
Large B Cell
Sign in / Sign up

Export Citation Format

Share Document