scholarly journals Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O6-methylguanine DNA-methyltransferase, in breast cancer cells

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Shaohua Chen ◽  
Yu Zhang ◽  
Daohai Zhang
Keyword(s):  
Breast Cancer ◽  
Endoplasmic Reticulum ◽  
Dna Repair ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Dna Methyltransferase ◽  
Repair Gene ◽  
Methylguanine Dna Methyltransferase ◽  
Dna Repair Gene ◽  
Endoplasmic Reticulum Protein

scholarly journals The Effect of a DNA Repair Gene on Cellular Invasiveness: Xrcc3 Over-Expression in Breast Cancer Cells

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16394 ◽  
Author(s):  
Veronica L. Martinez-Marignac ◽  
Amélie Rodrigue ◽  
David Davidson ◽  
Martin Couillard ◽  
Ala-Eddin Al-Moustafa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Repair Gene ◽  
Over Expression ◽  
Dna Repair Gene ◽  
Cellular Invasiveness

Methylenetetrahydrofolate Reductase Genotype in Diffuse Large B-Cell Lymphomas with and without Hypermethylation of the DNA Repair Gene O6-Methylguanine DNA Methyltransferase

2003 ◽  
Vol 18 (3) ◽  
pp. 218-221 ◽  
Author(s):  
G. Toffoli ◽  
D. Rossi ◽  
G. Gaidano ◽  
E. Cecchin ◽  
M. Boiocchi ◽  
...  
Keyword(s):  
Dna Repair ◽  
B Cell ◽  
Dna Methyltransferase ◽  
Methylenetetrahydrofolate Reductase ◽  
B Cell Lymphomas ◽  
Repair Gene ◽  
Mthfr Polymorphisms ◽  
Methylguanine Dna Methyltransferase ◽  
Dna Repair Gene ◽  
Large B Cell

C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been suggested to affect susceptibility to malignant lymphoma, possibly by altering DNA methylation. The DNA repair gene O6-methylguanine DNA methyltransferase (MGMT) is transcriptionally silenced by promoter hypermethylation in diffuse large B-cell lymphomas (DLBCL). We analyzed the MTHFR677 and MTHFR1298 genotypes in 111 DLBCL patients and 465 controls. No significant difference in the frequency of MTHFR polymorphisms between patients and controls and no significant association between MTHFR677 or MTHFR1298 genotypes and methylation of MGMT promoter were observed. These results indicate that MTHFR variants are not related to DLBCL development and MGMT hypermethylation.

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