Optical Coherence Tomography Angiography in Retinal Vein Occlusion Treated with Dexamethasone Implant: A New Test for Follow-Up Evaluation

2016 ◽  
Vol 26 (5) ◽  
pp. 460-468 ◽  
Author(s):  
Agnes Glacet-Bernard ◽  
Alexandre Sellam ◽  
Florence Coscas ◽  
Gabriel Coscas ◽  
Eric H. Souied
2021 ◽  
Vol 10 (7) ◽  
pp. 1423
Author(s):  
Swetapadma Tripathy ◽  
Hong-Gam Le ◽  
Maria Vittoria Cicinelli ◽  
Manjot K. Gill

Background: To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO). Methods: Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control. Results: Twelve RVO eyes were included, receiving 6 ± 3 anti-VEGF injections over a follow-up of 10.4 ± 3.1 months. Compared to fellow eyes, RVO eyes had lower VD and VLD at inclusion (p = 0.07 and p = 0.04) and last visit (p = 0.002 and p < 0.001). VD, AFI, and VLD did not change over time, while FAZ area increased in RVO eyes (+0.016 ± 0.024 mm2, p = 0.04). AFI correlated with duration of disease (r = 0.63, p = 0.02). Visual acuity was inversely related to VD and VLD over the follow-up. Conclusions: OCTA parameters remained stable with sustained anti-VEGF treatment in RVO, while changes in the FAZ area may suggest capillary remodeling after RVO.


Retina ◽  
2017 ◽  
Vol 37 (6) ◽  
pp. 1176-1184 ◽  
Author(s):  
Alexandre Sellam ◽  
Agnes Glacet-Bernard ◽  
Florence Coscas ◽  
Alexandra Miere ◽  
Gabriel Coscas ◽  
...  

Even though the diagnosis depends on clinical examination, in cases with branch retinal vein occlusion (BRVO), fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA) provide unique data for follow-up, management and prognosis. In FFA, delay of laminar flow phase in the involved branch, hyperfluorescence due to leakage from the vessel wall in the late phases, hypofluorescence due to the blockage by hemorrhage, and soft exudates, and hyperfluorescence due to macular edema can be detected. In OCT, macular thickening, cystic spaces, serous retinal detachment, hyperreflective dots, disorganization of the outer retinal layers – particularly the photoreceptor inner and outer segments line and the external limiting membrane – can be seen. OCTA reveals non-perfusion, particularly in the deep capillary plexus.


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