scholarly journals The structural and comparative analysis of intravitreal dexamethasone implant (Ozurdex) and anti‐VEGF injection in branched retinal vein occlusion patients by optical coherence tomography angiography images quantitation

2021 ◽  
Vol 99 (S265) ◽  
Author(s):  
JinHeung Park
2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Rodolfo Mastropasqua ◽  
Lisa Toto ◽  
Luca Di Antonio ◽  
Enrico Borrelli ◽  
Alfonso Senatore ◽  
...  

Abstract The aim of this study was to evaluate retinal and choriocapillaris vessel density using optical coherence tomography angiography (OCTA) in eyes with central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO) complicated by macular edema (ME). Sixty eyes of 60 patients with CRVO or BRVO and ME and 40 healthy subjects underwent measurements of superficial and deep foveal and parafoveal vessel density (FVD, PFVD) and choricapillary density using OCTA at baseline and 60 days after intravitreal dexamethasone implant (IVDEX). FVD and PFVD of the superficial plexus were not significantly lower in CRVO group compared to the controls while in the BRVO group overall PFVD were significantly lower compared to control group (p < 0.001). Overall PFVD of the deep plexus was significantly lower in CRVO and BRVO groups compared to the control group (p < 0.001). FVD and overall PFVD of choriocapillaris were significantly reduced compared to controls in CRVO group (p < 0.001) and PFVD of choriocapillaris was significantly reduced compared to controls in the affected hemi fields in BRVO groups (p < 0.001). OCTA showed vessel density reduction in BRVO and CRVO with main involvement of the deep retinal plexus compared to the superficial retinal plexus due to ischemia that did not recover after intravitreal dexamethasone implant.


2021 ◽  
Vol 10 (7) ◽  
pp. 1423
Author(s):  
Swetapadma Tripathy ◽  
Hong-Gam Le ◽  
Maria Vittoria Cicinelli ◽  
Manjot K. Gill

Background: To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO). Methods: Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control. Results: Twelve RVO eyes were included, receiving 6 ± 3 anti-VEGF injections over a follow-up of 10.4 ± 3.1 months. Compared to fellow eyes, RVO eyes had lower VD and VLD at inclusion (p = 0.07 and p = 0.04) and last visit (p = 0.002 and p < 0.001). VD, AFI, and VLD did not change over time, while FAZ area increased in RVO eyes (+0.016 ± 0.024 mm2, p = 0.04). AFI correlated with duration of disease (r = 0.63, p = 0.02). Visual acuity was inversely related to VD and VLD over the follow-up. Conclusions: OCTA parameters remained stable with sustained anti-VEGF treatment in RVO, while changes in the FAZ area may suggest capillary remodeling after RVO.


Retina ◽  
2017 ◽  
Vol 37 (6) ◽  
pp. 1176-1184 ◽  
Author(s):  
Alexandre Sellam ◽  
Agnes Glacet-Bernard ◽  
Florence Coscas ◽  
Alexandra Miere ◽  
Gabriel Coscas ◽  
...  

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