Discomfort Symptoms Reduction and Ocular Surface Parameters Recovery with Artelac Rebalance Treatment in Mild–moderate Dry Eye

2013 ◽  
Vol 23 (4) ◽  
pp. 488-495 ◽  
Author(s):  
Piera Versura ◽  
Vincenzo Profazio ◽  
Giuseppe Giannaccare ◽  
Michela Fresina ◽  
Emilio C. Campos
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Surface Parameters

scholarly journals The Deterioration of Meibomian Gland Over the Duration of Sjögren Syndrome

2021 ◽  
Author(s):  
Mi Yeon Song ◽  
Sung Rae Noh ◽  
Kook Young Kim ◽  
Kyu Yeon Hwang ◽  
Young A Kwon ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Meibomian Gland ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Strong Positive Correlation ◽  
Surface Parameters ◽  
Standard Patient ◽  
Average Maximum ◽  
Positive Correlations

Abstract Purpose: To investigate the correlation between Sjögren syndrome (SS) duration and ocular surface parameters in patients with SS-related dry eye. Methods: We analyzed 108 eyes of 108 female patients with primary SS-related dry eye. Meibomian gland (MG) dysfunction, MG dropout, lipid layer thickness (LLT), partial and total blinking, and partial blinking rate (PBR) were measured using a LipiView® II ocular surface interferometer (TearScience, Morrisville, NC, USA). All patients underwent rheumatoid serologic tests and ocular surface assessments. The ocular surface assessment included the Standard Patient Evaluation of Eye Dryness (SPEED), Schirmer’s I test, non-invasive tear break-up time, and grading of corneal/conjunctival staining. The correlations between SS duration and MG dropout rates as well as other ocular surface parameters were determined. Results: The mean SS duration was 54.1±41.3 months. There was a strong positive correlation between SS duration and MG dropout (r = 0.766, p < 0.001). The average, maximum, and minimum LLTs showed a weak negative correlation with SS duration (r = -0.310, -0.211, and - 0.304, respectively, p = 0.014, 0.028, and 0.022, respectively) and MG dropout (r = -0.191, -0.326, and -0.299, respectively, p = 0.049, 0.002, and 0.009, respectively). Significant positive correlations were also observed between the SPEED scores and SS duration (r = 0.303, p = 0.042) and MG dropout (r = 0.450, p = 0.029). Conclusions: Longer durations of primary SS-related dry eye were associated with worse MG dysfunction.

scholarly journals Analysis of tear inflammatory molecules and clinical correlations in evaporative dry eye disease caused by meibomian gland dysfunction

2020 ◽  
Vol 40 (11) ◽  
pp. 3049-3058
Author(s):  
Xingdi Wu ◽  
Xiang Chen ◽  
Yajuan Ma ◽  
Xueqi Lin ◽  
Xuewen Yu ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Healthy Subjects ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Surface Parameters ◽  
Tnf Α ◽  
Evaporative Dry Eye ◽  
Ifn Γ ◽  
Inflammatory Molecules

Abstract Purpose To compare the levels of inflammatory molecules in tear samples between patients with meibomian gland dysfunction (MGD)-related evaporative dry eye (EDE) and healthy subjects and to analyze the correlations between the levels of tear inflammatory molecules and ocular surface parameters. Methods A total of 30 MGD-related EDE patients (48 eyes) and ten healthy volunteers (15 eyes) were enrolled. Dry eye-related examinations and questionnaires were obtained from all participants. The levels of nine inflammatory molecules were determined through multiplex bead analysis. Results Inflammatory molecules including ICAM-1, IFN-γ, CXCL8/IL-8, IL-6, TNF-α and IL-12p70 were detected in 100% of the patients, while IL-1α, IL-1β and IL-10 were detected in 56.25%, 13.60% and 45.83% of the patients, respectively. Moreover, ICAM-1, IL-8, IL-6, TNF-α, IL-12p70 and IFN-γ were detected in 86.67–100% of the healthy subjects, and the detection rates of IL-10, IL-1α and IL-1β were below 50%. The levels of IL-8, IL-6, IFN-γ and ICAM-1 were significantly higher in the patient group compared with the control group. In addition, IL-8 and IL-6 were negatively correlated with Schirmer I test. Besides, IFN-γ was negatively correlated with tear film breakup time. Furthermore, ICAM-1 and IL-6 were positively correlated with meibography score. Conclusions Collectively, patients with MGD-related EDE had higher levels of inflammatory molecules in their tears, and some molecules were correlated with ocular surface parameters. These findings suggested that inflammation played an important role in MGD-related EDE, and several inflammatory molecules could be used in the diagnosis and the treatment of MGD-related EDE.

FRI0330 Predictivity of Ocular Surface Parameters and Tear Protein Expression in The Diagnosis of Sjögren Syndrome versus Dry Eye

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 554.2-554
Author(s):  
G. Vukatana ◽  
P. Versura ◽  
M. Trevisani ◽  
P. Giannaccare ◽  
A. Buffa ◽  
...  
Keyword(s):  
Protein Expression ◽  
Dry Eye ◽  
Ocular Surface ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Surface Parameters ◽  
Tear Protein

Tear Osmolarity and Correlation With Ocular Surface Parameters in Patients With Dry Eye

Cornea ◽  
2017 ◽  
Vol 36 (11) ◽  
pp. 1352-1357 ◽  
Author(s):  
Priya M. Mathews ◽  
Sezen Karakus ◽  
Devika Agrawal ◽  
Holly B. Hindman ◽  
Pradeep Y. Ramulu ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Surface Parameters

scholarly journals The prevalence of meibomian gland dysfunction, tear film and ocular surface parameters in an Austrian dry eye clinic population

2018 ◽  
Vol 96 (6) ◽  
Author(s):  
Dieter Franz Rabensteiner ◽  
Haleh Aminfar ◽  
Ingrid Boldin ◽  
Gerold Schwantzer ◽  
Jutta Horwath‐Winter
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Meibomian Gland ◽  
Meibomian Gland Dysfunction ◽  
Surface Parameters ◽  
Clinic Population ◽  
Eye Clinic

scholarly journals Evaluation of tear osmolarity measured by I-Pen osmolarity system in patients with dry eye

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jongyeop Park ◽  
Youngjoo Choi ◽  
Gyule Han ◽  
Eunhae Shin ◽  
Jisang Han ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Refractive Surgery ◽  
Medical Center ◽  
Control Group ◽  
Schirmer Test ◽  
Ocular Surface Disease Index ◽  
Surface Parameters ◽  
Retrospective Comparative Study ◽  
Surgery Center

AbstractThis retrospective comparative study was to evaluate tear osmolarity measured by I-Pen osmolarity system (I-MED Pharma Inc, Dollard-des-Ormeaux, Quebec, Canada) in healthy subjects without dry eye disease (DED) and patients with DED, and its association with other ocular surface parameters. This study comprised 65 eyes of 65 patients. The ocular surface parameters including tear osmolarity with I-Pen osmometer of the patients who visited the refractive surgery center of Samsung Medical Center between January 1, 2020 and May 31, 2020 were retrospectively collected. The subjects were divided as asymptomatic normal group and symptomatic dry eye group. The distribution of tear osmolarity and its association with other ocular surface parameters were evaluated. Total thirty-two patients (32 eyes) were included in the control group, and 33 patients (33 eyes) were included in the DED group. Tear osmolarity was significantly higher in the DED group. Tear osmolarity was negatively correlated with tear break-up time, and the Schirmer test, and was positively correlated with Ocular Surface Disease Index symptom score. The cut-off value of 318 mOsm/L showed a sensitivity of 90.9% and specificity of 90.6% for diagnosing DED. The I-Pen osmometer can be considered suitable for use in the clinical setting, with good performance in DED diagnosis.

Sign in / Sign up

Export Citation Format

Share Document