Editorial Volume 17 Issue 4 – Assessing, treating and prognosticating from the front door

2018 ◽  
Vol 17 (4) ◽  
pp. 174-176
Author(s):  
Ben Lovell ◽  
◽  
Timothy Cooksley ◽  

In our daily working lives, acute physicians strive to provide the best holistic care to our patients from the moment they arrive in hospital. Experienced healthcare professionals develop a gut feeling (generally recognised as the nagging internal voice of professional experience) about patients who may be more unwell than appearances suggest, or who may deteriorate despite showing signs of physiologically compensating quite well. The papers in this issue challenge us to examine how we prioritise, prognosticate and risk-stratify the patients we treat in acute medicine, how we remain cognisant and skilled in treating patients with more unusual acute medical conditions, and how we allocate resources in the NHS. There are many reasons for a patient to re-attend the Emergency Department (ED) in the days following a discharge. In the UK, these unplanned re-attendances are measured as a quality indicator, implying that patient’s return to the ED is due to a deficiency in the quality of their care. In this issue, Ludwig et al challenge this simplistic view by exploring the reasons why patients to come back to the ED and describe how these re-attendances can be ascribed to factors related either to the patient, the physician or the illness itself. Is there a reliable way to predict mortality and likelihood to require critical care at the point of admission? Two papers in this issue cover the subject of prognostication in acute medicine. Most acute medics are wary of transplanting illness-severity metrics from other disciplines and installing indiscriminately them in the ED and AMU. However, Holm and Brabrand have established that the Sequential Organ Failure Assessment (SOFA) score, a longtime staple of the Intensive Care Unit (ICU), can predict deterioration and death with acceptable accuracy in acute medical patients. This suggests that the SOFA score may inform treatment escalation plans and patient prioritisation at the ‘front door’. Bindraban et al have used the haematological indices of the full blood count develop an understanding of how front line tests may predict the patient journey. Whilst common sense suggests that those with the most abnormal blood test results at admission have worse outcomes, this paper quantifies and elaborates the relationship between the results on the computer screen and the patient in the hospital bed. When Grenfell Tower blazed in June 2017, the nearby AMUs cleared their beds as best they could and stood by to receive patients suffering with smoke-related injuries. Occurrences such as this remind us that the acute physician must be up to date with rare but important medical emergencies. In their review, Björkbom and Brabrand highlight the phenomenon smoke inhalation injury, and advise us that the period of in-patient observation should be slightly longer than we realise. “The most intense spending on acute health care in a lifetime occurs in the last few months of life”; from this statement Jones and Kellett lay out their argument that local mortality rates should inform and influence local healthcare spending. In an article that should provoke debate, they suggests significant adjustments in how financial resources are allocated, and how a national death registry could impact upon how the NHS spends its money.

2021 ◽  
Vol 40 (4) ◽  
pp. S515
Author(s):  
E. Olsson ◽  
M. Silverborn ◽  
U. Smedh ◽  
G.C. Riise ◽  
J.M. Magnusson ◽  
...  

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S108-S109
Author(s):  
Nicholas Iglesias ◽  
Anesh Prasai ◽  
George Golovko ◽  
Deepak K Ozhathil ◽  
Steven E Wolf

Abstract Introduction For decades, controversy has raged regarding the placement of tracheostomy in severe paediatric burns. Numerous variables including extent of smoke inhalation injury, % TBSA burned, age of the patient, and co-morbidities among others complicate reaching consensus. Furthermore, paediatric patients are particularly susceptible to complications including inadvertent loss of airway and long-term swallowing and other anatomic issues. Additionally, previous analysis of the efficacy of tracheostomy in paediatric burn patients appears to be hindered by a lack of nationwide analysis. The aim of this study was to explore the efficacy of tracheostomy in the general paediatric burn patient population. Methods De-identified patient data was obtained from the TriNetX Research Network database. Two cohorts were identified: paediatric burn patients with tracheostomy (cohort A) and paediatric burn patients without tracheostomy (cohort B). Burn patients were identified using the ICD-10 codes T20-T25 & T30-T32. Tracheostomy was identified using the ICD-10 codes 1005887, 1014613, 31600, 31601, 31603, 31604, 31610, and Z93.0. A total of 132 patients were identified in cohort A in 23 HCOs and 83,117 patients were identified in cohort B in 38 HCOs. Infection, hypovolemia, pulmonary injury, laryngeal injury, pneumonia, and death were compared between the cohorts. Results Cohort A had a mean age of 11 (SD=5) and Cohort B had a mean age of 9 (SD=5). Paediatric burn patients with tracheostomy had a higher risk for death, infection, hypovolemia, pulmonary injury, laryngeal injury, and pneumonia when compared to their non-tracheostomy counterparts. The risk ratios for these outcomes were 62.452, 4.713, 9.267, 26.483, 116.163, and 18.154, respectively. Conclusions The analysis of the longitudinal outcomes of pediatric burn patients with tracheostomy as compared to those without tracheostomy demonstrated the tracheostomy cohort suffered much worse mortality and morbidity across several metrics. The potential benefits of tracheostomy placement in pediatric burn patients should be weighed against these outcomes.


2002 ◽  
Vol 283 (5) ◽  
pp. L1043-L1050 ◽  
Author(s):  
Jiro Katahira ◽  
Kazunori Murakami ◽  
Frank C. Schmalstieg ◽  
Robert Cox ◽  
Hal Hawkins ◽  
...  

We hypothesized that the antibody neutralization of L-selectin would decrease the pulmonary abnormalities characteristic of burn and smoke inhalation injury. Three groups of sheep ( n = 18) were prepared and randomized: the LAM-(1–3) group ( n = 6) was injected intravenously with 1 mg/kg of leukocyte adhesion molecule (LAM)-(1-3) (mouse monoclonal antibody against L-selectin) 1 h after the injury, the control group ( n = 6) was not injured or treated, and the nontreatment group ( n = 6) was injured but not treated. All animals were mechanically ventilated during the 48-h experimental period. The ratio of arterial Po 2 to inspired O2 fraction decreased in the LAM-(1–3) and nontreatment groups. Lung lymph flow and pulmonary microvascular permeability were elevated after injury. This elevation was significantly reduced when LAM-(1–3) was administered 1 h after injury. Nitrate/nitrite (NO x ) amounts in plasma and lung lymph increased significantly after the combined injury. These changes were attenuated by posttreatment with LAM-(1–3). These results suggest that the changes in pulmonary transvascular fluid flux result from injury of lung endothelium by polymorphonuclear leukocytes. In conclusion, posttreatment with the antibody for L-selectin improved lung lymph flow and permeability index. L-selectin appears to be principally involved in the increased pulmonary transvascular fluid flux observed with burn/smoke insult. L-selectin may be a useful target in the treatment of acute lung injury after burn and smoke inhalation.


Shock ◽  
2019 ◽  
Vol 51 (5) ◽  
pp. 634-649 ◽  
Author(s):  
Anita C. Randolph ◽  
Satoshi Fukuda ◽  
Koji Ihara ◽  
Perenlei Enkhbaatar ◽  
Maria-Adelaide Micci

BJA Education ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 143-148 ◽  
Author(s):  
Preea Gill ◽  
Rebecca V Martin

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