Relation Between Circadian Rhythm of Blood Pressure and Serum Uric Acid and Body Mass Index

2011 ◽  
Vol 20 (01) ◽  
pp. 32-37
Author(s):  
Mehmet Kanbay ◽  
Faruk Turgut ◽  
Ayse Isik ◽  
Mustafa Koroglu ◽  
Ali Akcay
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Circadian Rhythm ◽  
Serum Uric Acid ◽  
Body Mass

scholarly journals Associations between BMI, serum uric acid, serum glucose, and blood pressure with urinary tract stone opacity

2015 ◽  
Vol 24 (2) ◽  
pp. 103-8
Author(s):  
Ikhlas A. Bramono ◽  
Nur Rasyid ◽  
Ponco Birowo
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Urinary Tract ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Glucose Level ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Urinary Tract Stone

Background: Urolithiasis refers to formation of stone in the kidney, ureter, or bladder. Several studies showed metabolic abnormalities were common in urolithiasis patients. The aim of this study was to describe the association between body-mass-index (BMI), serum uric acid, serum glucose, and blood pressure toward stone opacity in urinary tract stone patients.Methods: This study was done retrospectively by reviewing registry data of urinary tract stone patients that had undergone ESWL on January 2008 – December 2013 in Department of Urology Cipto Mangunkusumo Hospital. Data concerning body mass index, serum uric acid, serum glucose, blood pressure, and urinary tract stone opacity were recorded. Associations between body mass index, serum uric acid, serum glucose and blood pressure with urinary tract stone opacity were analyzed using chi-square test.Results: There were 2,889 patients who underwent ESWL on January 2008 – December 2013. We analyzed 242 subjects with complete data. Mean age was ± 12.78 (48.02 years). Male-to-female ratio was 2.27:1. Mean BMI was ± 3.78 (29.91 kg/m2). High risk BMIs were found in 161 patients (66.52%). The proportion of radioopaque stone was 77.69% (188 patients). Twenty two patients (9.1%) had normal blood pressure. Patients with high serum uric acid were 34.30% (83 patients). We found a significant association between random serum glucose level and stone opacity (p < 0.05).Conclusion: There is an association between random serum glucose level and stone opacity in urolithiasis patients. Hyperglycemia patients tend to have radiolucent stone, whereas normoglycemia patients tend to have radioopaque stone.

Abstract P398: Uric Acid And Prehypertension: Salt Intake in Addition to Insulin Resistance are not Mediators.

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Paulo A Lotufo ◽  
Itamar S Santos ◽  
Isabela M Bensenor
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Body Mass ◽  
High Blood Pressure ◽  
Urinary Sodium ◽  
Full Model

Introduction: The association "uric acid and high blood pressure" is still matter of debate. Therefore, to distinguish serum uric acid as an independent factor for high blood pressure can start new trials to prevent hypertension. A paleoantropological rationale for this association was a knockout of uricase occurred during the Miocene among hominids that induced high levels of uric acid. As consequence, during food shortage times, high uric acid had an evolutionary benefit increasing salt-sensitivity for keep blood pressure and rising insulin resistance that maintaining high blood glucose levels provided fuel for the brain. Nowadays, the average levels of uric acid are substantially higher compared to chimpanzees, a uricase-deficient primate, and among remote populations as the yanomamo. Hypothesis: we assessed the hypothesis that the link between uric acid and blood pressure in individuals without hypertension is independent of sex, age, race, salt and alcohol intakes, glucose homeostasis, body-mass index and renal function. Methods: from the 15105 participants of the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) aged 35-74 years, we selected 7954 individuals (median age = 48 years-old; women =58.1; White = 56.6%) without hypertension, diabetes, previous cardiovascular diseases. The presence or not of prehypertension (7th JNC criteria) was the dependent variable and quartiles (Q) of serum uric acid, the independent variable. We applied an unconditional logistic regression adjusted for age and sex. After this, according to our hypothesis, we added the following variables: (1) 24-hour urinary sodium; (2) log Homeostasis Model Assessment (fasting blood glucose (mg/dL) х fasting insulin (mg/dL)/450), and (3) a full model, adding race, body-mass index, alcohol intake, and glomerular filtration rate by CKD-epi). Results: the uric acid quartiles ranges (md/dL) were Q1 ≤ 4.1; Q2:4.2-5.0; Q3:5.1-6.0; Q4: ≥ 6.1 and the number of participants were Q1= 1909; Q2=2029; Q3=2000; Q4= 2016. Considering Q1 as reference, the age-sex adjusted odds ratios (95% Confidence Interval) through the quartiles were: Q2= 1.22 (1.05-1.41); Q3= 1.40 (1.20-1.63); Q4= 2.03 (1.71-2.39) [P for trend <0.001]. Adding 24 hour urinary sodium, the ORs (95% CI) were: Q2= 1.19 (1.01-1.40); Q3= 1.37 (1.16-1.62); and 1.94 (1.61-2.33) [P for trend <0.001]. Adding HOMA-IR, the ORs (95% CI) were: Q2= 1.14 (0.97-1.34); Q3= 1.25(1.05-1.48); and Q4=1.62(1.34-1.96) [P for trend <0.001]. Finally, for the full model the ORs were Q2= 1.04 (0.88-1.23); Q3= 1.05 (0.88-1.26) and Q4= 1.32(1.08-1.62) [P for trend <0. 01]. Conclusion: Uric acid levels were correlated to prehypertension among a middle-aged urban population. It occurred independently of other variables classically associated to high blood pressure or the origin of higher uric acid in hominids.

scholarly journals A correlative study of body mass index with oxidative stress parameters (serum uric acid and serum malondialdihyde) in essential hypertension

2019 ◽  
Vol 7 (4) ◽  
pp. 1252 ◽  
Author(s):  
Chanchal Shrivastav ◽  
Paras Arvindbhai Parekh ◽  
G. Indra Kumar
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Essential Hypertension ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Oxidative Stress Marker ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Background: Hypertension is most commonly documented modifiable risk factor for cardiovascular diseases. A growing body of data proposes an appreciated pathogenic role of an elevated serum uric acid in atherosclerosis and cardiovascular disease (CVD). Increased oxidative stress could be involved in the pathogenesis of hypertension. Oxidative stress marker, serum uric acid (SUA) and serum malondialdyhyde level (S. MDA) are affected by both genetic and environmental factors and related to biological factors as gender, age and body mass. So, the aim of the study is to access the association of body mass index (BMI) with oxidative stress parameters in essential hypertension (EHT).Methods: For the said purpose, this case control study was carried out on a total of 200, age and sex matched 75 hypertensives, 75 prehypertensive and 50 healthy subjects. After diagnosis of cases, SUA was estimated by standard kit method and S. MDA was estimated manually by Buege and Aust method.Results: This study represents that systolic and diastolic blood pressure were increased with increased BMI in all groups. Oxidative stress marker, SUA and S. MDA level increased significantly with increasing BMI in all groups and were positively correlated.Conclusions: Our study indicates that monitoring of the blood pressure, SUA and S. MDA at regular interval and maintaining of the oxidative balance would be helpful in preventing the development of hypertension and associated cardio-vascular morbidities.

scholarly journals Relationship between uric acid, blood pressure and anthropometric indices in a healthy Ghanaian adult population

2020 ◽  
Vol 8 (12) ◽  
pp. 4185
Author(s):  
Perez Quartey ◽  
Bright Afriyie Owusu ◽  
Lawrence Marfo ◽  
Emmanuel Appiah
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Waist Circumference ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Statistical Significance ◽  
Anthropometric Indices ◽  
Significant Difference ◽  
Positive Correlations

Background: Age- and sex-dependent variations in the relationship between uric acid and blood pressure and anthropometric indices have been reported in some populations. However, this has not been studied in a Ghanaian adult population.Methods: Body mass index, waist circumference, blood pressure and serum uric acid levels were measured. Categorical differences were analysed with chi-square. Differences between groups were assessed by t-test and one-way analysis of variance. Association between serum uric acid and baseline characteristics of age, body mass index, waist circumference and blood pressure was assessed by Pearson’s correlation. Statistical significance was pegged at p<0.05.Results: Prevalence of hyperuricemia was 3.2%. There was no significant difference in prevalence of hypertension between males (28.6%) and females (28.9%). General obesity and central obesity prevalence were significantly higher among females. In males, serum uric acids levels had statistically non-significant positive correlations with age, blood pressure, waist circumference and body mass index. In females, the results showed that among women less than 45 years, serum uric acid had significant positive correlations with only body mass index and waist circumference. However, significant positive correlations were observed between all the baseline parameters and uric acid among women who are 45 years and above.Conclusions: Increasing serum uric acid levels are significantly associated with higher blood pressure, body mass index and waist circumference. This relationship is stronger in females than in males, with the age group ≥45 years being the main determinant of this relationship.

scholarly journals Serum Periostin as a Potential Biomarker in Pediatric Patients with Primary Hypertension

2021 ◽  
Vol 10 (10) ◽  
pp. 2138
Author(s):  
Michał Szyszka ◽  
Piotr Skrzypczyk ◽  
Anna Stelmaszczyk-Emmel ◽  
Małgorzata Pańczyk-Tomaszewska
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Body Mass ◽  
Pediatric Patients ◽  
Univariate Analysis ◽  
Primary Hypertension ◽  
Potential Biomarker ◽  
Arterial Damage ◽  
Serum Periostin

Experimental studies suggest that periostin is involved in tissue repair and remodeling. The study aimed to evaluate serum periostin concentration as potential biomarker in pediatric patients with primary hypertension (PH). We measured serum periostin, blood pressure, arterial damage, biochemical, and clinical data in 50 children with PH and 20 age-matched healthy controls. In univariate analysis, children with PH had significantly lower serum periostin compared to healthy peers (35.42 ± 10.43 vs. 42.16 ± 12.82 [ng/mL], p = 0.038). In the entire group of 70 children serum periostin concentration correlated negatively with peripheral, central, and ambulatory blood pressure, as well as with aortic pulse wave velocity (aPWV). In multivariate analysis, periostin level significantly correlated with age (β = −0.614, [95% confidence interval (CI), −0.831–−0.398]), uric acid (β = 0.328, [95%CI, 0.124–0.533]), body mass index (BMI) Z-score (β = −0.293, [95%CI, −0.492–−0.095]), high-density lipoprotein (HDL)-cholesterol (β = 0.235, [95%CI, 0.054–0.416]), and triglycerides (β = −0.198, [95%CI, −0.394–−0.002]). Neither the presence of hypertension nor blood pressure and aPWV influenced periostin level. To conclude, the role of serum periostin as a biomarker of elevated blood pressure and arterial damage in pediatric patients with primary hypertension is yet to be unmasked. Age, body mass index, uric acid, and lipid concentrations are key factors influencing periostin level in pediatric patients.

Abstract P146: Uric Acid is an Independent Risk Factor for Developing Hypertension From Prehypertension: A 5-year Japanese Cohort Study

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Masanari Kuwabara ◽  
Shigeko Hara ◽  
Koichiro Niwa ◽  
Minoru Ohno ◽  
Ichiro Hisatome
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Risk Factor ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Drinking Habits

Objectives: Prehypertension frequently progresses to hypertension and is associated with cardiovascular diseases, stroke, excess morbidity and mortality. However, the identical risk factors for developing hypertension from prehypertension are not clarified. This study is conducted to clarify the risks. Methods: We conducted a retrospective 5-year cohort study using the data from 3,584 prehypertensive Japanese adults (52.1±11.0 years, 2,081 men) in 2004 and reevaluated it 5 years later. We calculated the cumulative incidences of hypertension over 5 years, then, we detected the risk factors and calculated odds ratios (ORs) for developing hypertension by crude analysis and after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric acid. We also evaluated whether serum uric acid (hyperuricemia) provided an independent risk for developing hypertension. Results: The cumulative incidence of hypertension from prehypertension over 5 years was 25.3%, but there were no significant differences between women and men (24.4% vs 26.0%, p=0.28). The cumulative incidence of hypertension in subjects with hyperuricemia (n=726) was significantly higher than those without hyperuricemia (n=2,858) (30.7% vs 24.0%, p<0.001). After multivariable adjustments, the risk factors for developing hypertension from prehypertension were age (OR per 1 year increased: 1.023; 95% CI, 1.015-1.032), women (OR versus men: 1.595; 95% CI, 1.269-2.005), higher body mass index (OR per 1 kg/m 2 increased: 1.051; 95% CI 1.021-1.081), higher baseline systolic blood pressure (OR per 1 mmHg increased: 1.072; 95% CI, 1.055-1.089) and diastolic blood pressure (OR per 1 mmHg increased: 1.085; 95% CI, 1.065-1.106), and higher serum uric acid (OR pre 1 mg/dL increased: 1.149; 95% CI, 1.066-1.238), but not smoking and drinking habits, diabetes mellitus, dyslipidemia, and chronic kidney diseases. Conclusions: Increased serum uric acid is an independent risk factor for developing hypertension from prehypertension. Intervention studies are needed to clarify whether the treatments for hyperuricemia in prehypertensive subjects are useful.

scholarly journals Serum uric acid as a predictor of future hypertension: Stratified analysis based on body mass index and age

2016 ◽  
Vol 90 ◽  
pp. 201-206 ◽  
Author(s):  
Yuki Yokoi ◽  
Takahisa Kondo ◽  
Naoki Okumura ◽  
Keiko Shimokata ◽  
Shigeki Osugi ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Stratified Analysis

scholarly journals Nonlinear relationship between serum uric acid and body mass index: a cross-sectional study of a general population in coastal China

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Hui Zhou ◽  
Zhen Liu ◽  
Zhong Chao ◽  
Yeqing Chao ◽  
Lidan Ma ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Uric Acid ◽  
General Population ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Large Scale ◽  
Cross Sectional ◽  
Men And Women ◽  
Nadir Point ◽  
Coastal China

Abstract Background Conflicting evidence exists on the relationship between body mass index (BMI) and serum uric acid (SUA). Therefore, we aimed to evaluate the SUA–BMI relationship in a large-scale epidemiological survey in coastal China. Methods This survey was conducted among the general population in the coastal region of China from September 2014 to January 2015. SUA Levels were measured by the automatic Sysmex Chemix-180 biochemical analyzer. Results A total of 6098 men (BMI: 24.58 ± 3.74 kg/m2) and 7941 women (24.56 ± 3.64 kg/m2) were included in this study. A stronger positive BMI-SUA association was found for men than women (all P-values < 0.05). The piecewise linear spline models indicated a U-shaped relationship of SUA-BMI association for both men and women; and the lowest turning points were at 19.12 kg/m2 for men and 21.3 kg/m2 for women. When BMIs were lower than the nadir point, each 1 kg/m2 increase in BMI related to a 7.74-fold (95% CI − 14.73, − 0.75) reduction for men and 2.70-fold reduction (− 4.47, − 0.94) for women in SUA levels. Once the BMI was higher than the nadir point, each 1 kg/m2 increase in BMI was related to a 5.10-fold (4.44, 5.77) increment for men and 3.93-fold increment (3.42, 4.43) for women in SUA levels. The regression coefficient differences between the two stages were 12.84 (5.66, 20.03) for men and 6.63 (4.65, 8.61) for women. Conclusions A U-shaped relationship between BMI and SUA was found for both men and women; the association was stronger for men than women.

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