scholarly journals Neurodegeneration, memory loss, and dementia: the impact of biological clocks and circadian rhythm

10.52586/4971 ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 614
Keyword(s):  
Circadian Rhythm ◽  
Memory Loss ◽  
Biological Clocks ◽  
The Impact

scholarly journals Circadian Clock, Sleep, and Diet

2021 ◽  
Author(s):  
Junichiro Irie
Keyword(s):  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Metabolic Regulation ◽  
Biological Clocks ◽  
Metabolic Alterations ◽  
Sleep Homeostasis ◽  
Peripheral Clocks ◽  
Central Clock ◽  
The Impact

Circadian rhythm is a fundamental process of sustaining metabolic homeostasis by predicting changes in the environment. This is driven by biological clocks, which operate within a 24-h period to orchestrate daily variation of metabolism and sleep. The central clock in the hypothalamus is the master keeper of the circadian rhythm and is primarily reset by light, while the feeding-fasting rhythm, that is, nutritional stimulus, entrains peripheral clocks in peripheral organs such as the intestine and liver. Nutritional stimuli are important modulators of peripheral circadian rhythms and may affect the central clock and sleep homeostasis through metabolic alterations. In this chapter, I will summarize the significance of circadian rhythm and sleep in metabolic regulation as well as discuss the impact that diet has on circadian rhythm and sleep.

The Status of Mind and Intellect in Digital Environment

2020 ◽  
Vol 63 (2) ◽  
pp. 123-143
Author(s):  
Elena I. Yaroslavtseva
Keyword(s):  
Human Life ◽  
Cognitive Activity ◽  
Memory Loss ◽  
Natural Material ◽  
Human Being ◽  
Connection To Nature ◽  
Digital World ◽  
The Status ◽  
Natural Foundation ◽  
The Impact

The article examines the impact of digitalization on human life and intellectual experience. The development of computer technology demands an understanding of new aspects of human development and requires a capability to overcome not only external conditions but also ourselves. Entering a new level of development cannot imply a complete rejection of previous dispositions, but should be accompanied by reflection on personal experience and by the quest for new forms of interaction in society and with nature. Communicative and cognitive activity of a person has an ontological basis and relies on processes that actually evolve in nature. Therefore, the creation of new objects is always associated with the properties of natural material and gives rise to new points of support in the development of man. The more audacious his projects, the more important it is to preserve this connection to nature. It is always the human being who turns out to be the initiator who knows how to solve problems. The conformity of complex technical systems to nature is not only a goal but also a value of meaningful construction of development perspectives. The key to the nature orientation of the modern digital world is the human being himself, who keeps all the secrets of the culture of his natural development. Therefore, the proposed by the Russian philosopher V.S. Stepin post-non-classical approach, based on the principle of “human-sizedness,” is an important contribution to contemporary research because it draws attention to the “human – machine” communication, to the relationship between a person and technological systems he created. The article concludes that during digital transformation, a cultural conflict arises: in an effort to solve the problems of the future, a person equips his life with devices that are designed to support him, to expand his functionality, but at the same time, the boundaries of humanity become dissolved and the forms of human activity undergo simplification. Transhumanism engages society in the fight against fears of vulnerability and memory loss and ignores the flexibility and sustainability of natural foundation.

scholarly journals The Impact of Bone on the Biology of Aging

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-740
Author(s):  
Gerard Karsenty
Keyword(s):  
Muscle Function ◽  
Male Fertility ◽  
Leydig Cells ◽  
Memory Loss ◽  
Age Related ◽  
Systematic Exploration ◽  
Biology Of Aging ◽  
The Impact ◽  
The Brain ◽  
Regulate Energy Metabolism

Abstract We hypothesized that bone may secrete hormones that regulate energy metabolism and reproduction. Testing this hypothesis revealed that the osteoblast-specific secreted protein osteocalcin is a hormone regulating glucose homeostasis and male fertility by signaling through a GPCR, Gprc6a, expressed in pancreatic β bells and Leydig cells of the testes. The systematic exploration of osteocalcin biology, revealed that it regulates an unexpectedly large spectrum of physiological functions in the brain and peripheral organs and that it has most features of an antigeromic molecule. As will be presented at the meeting, this body of work suggests that harnessing osteocalcin for therapeutic purposes may be beneficial in the treatment of age-related diseases such as depression, age-related memory loss and the decline in muscle function seen in sarcopenia.

scholarly journals The impact of statins on biological characteristics of stem cells provides a novel explanation for their pleiotropic beneficial and adverse clinical effects

2015 ◽  
Vol 309 (8) ◽  
pp. C522-C531 ◽  
Author(s):  
Reza Izadpanah ◽  
Deborah J. Schächtele ◽  
Andreas B. Pfnür ◽  
Dong Lin ◽  
Douglas P. Slakey ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cardiovascular Mortality ◽  
Memory Loss ◽  
Clinical Effects ◽  
Differentiation Potential ◽  
Plaque Instability ◽  
Fibrous Cap ◽  
Macrophage Density ◽  
Increased Risk ◽  
The Impact

Statins reduce atherosclerotic events and cardiovascular mortality. Their side effects include memory loss, myopathy, cataract formation, and increased risk of diabetes. As cardiovascular mortality relates to plaque instability, which depends on the integrity of the fibrous cap, we hypothesize that the inhibition of the potential of mesenchymal stem cells (MSCs) to differentiate into macrophages would help to explain the long known, but less understood “non-lipid-associated” or pleiotropic benefit of statins on cardiovascular mortality. In the present investigation, MSCs were treated with atorvastatin or pravastatin at clinically relevant concentrations and their proliferation, differentiation potential, and gene expression profile were assessed. Both types of statins reduced the overall growth rate of MSCs. Especially, statins reduced the potential of MSCs to differentiate into macrophages while they exhibited no direct effect on macrophage function. These findings suggest that the limited capacity of MSCs to differentiate into macrophages could possibly result in decreased macrophage density within the arterial plaque, reduced inflammation, and subsequently enhance plaque stability. This would explain the non-lipid-associated reduction in cardiovascular events. On a negative side, statins impaired the osteogenic and chondrogenic differentiation potential of MSCs and increased cell senescence and apoptosis, as indicated by upregulation of p16, p53 and Caspase 3, 8, and 9. Statins also impaired the expression of DNA repair genes, including XRCC4, XRCC6, and Apex1. While the effect on macrophage differentiation explains the beneficial side of statins, their impact on other biologic properties of stem cells provides a novel explanation for their adverse clinical effects.

Insulin resistance induced by long-term sleep deprivation in rhesus macaques can be attenuated by Bifidobacterium

2021 ◽  
Author(s):  
Ying Zhao ◽  
Yan Shu ◽  
Ning Zhao ◽  
Zili Zhou ◽  
Xiong Jia ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Circadian Rhythm ◽  
Blood Glucose ◽  
Glucose Metabolism ◽  
Sleep Deprivation ◽  
Rhesus Macaques ◽  
Intravenous Glucose ◽  
Increased Risk ◽  
The Impact

Long-term sleep deprivation (SD) is a bad lifestyle habit, especially among specific occupational practitioners, characterized by circadian rhythm misalignment and abnormal sleep/wake cycles. SD is closely associated with an increased risk of metabolic disturbance, particularly obesity and insulin resistance. The incretin hormone, glucagon-like peptide-1 (GLP-1), is a critical insulin release determinant secreted by the intestinal L-cell upon food intake. Besides, the gut microbiota participates in metabolic homeostasis and regulates GLP-1 release in a circadian rhythm manner. As a commonly recognized intestinal probiotic, Bifidobacterium has various clinical indications regarding its curative effect. However, few studies have investigated the effect of Bifidobacterium supplementation on sleep disorders. In the present study, we explored the impact of long-term SD on the endocrine metabolism of rhesus monkeys and determined the effect of Bifidobacterium supplementation on the SD-induced metabolic status. Lipids concentrations, body weight, fast blood glucose, and insulin levels increased after SD. Furthermore, after two months of long-term SD, the intravenous glucose tolerance test (iVGTT) showed that the glucose metabolism was impaired and the insulin sensitivity decreased. Moreover, one month of Bifidobacterium oral administration significantly reduced blood glucose and attenuated insulin resistance in rhesus macaques. Overall, our results suggested that Bifidobacterium might be used to alleviate SD-induced aberrant glucose metabolism and improve insulin resistance. Also, it might help in better understanding the mechanisms governing the beneficial effects of Bifidobacterium.

scholarly journals 17Α-METHYLTESTOSTERONE (ANABOLIC ANDROGENIC STEROIDS) ALTERS ACETYLCHOLINESTERASE ENZYME ACTIVITY IN DIFFERENT PARTS OF THE BRAIN IN FEMALE MICE, MUS MUSCULUS

2018 ◽  
Vol 11 (5) ◽  
pp. 410
Author(s):  
Sachin B Patil ◽  
Laxmi S Inamdar
Keyword(s):  
Enzyme Activity ◽  
Ache Activity ◽  
Negative Impact ◽  
Memory Loss ◽  
Anabolic Androgenic Steroids ◽  
Female Mice ◽  
Neuronal Transmission ◽  
Androgenic Steroids ◽  
The Impact ◽  
Different Parts

Aim: Anabolic androgenic steroids (AAS) are synthetic derivatives of the male sex hormone testosterone. Androgens and anabolic steroids have been used for therapeutic purpose with few exceptions. However, the abuse of AAS is a remarkably prevalent problem, particularly among athletes and adolescents. Supraphysiological doses of AAS exert profound effects on mental state and behaviors such as depression, anxiety, aggressiveness, and cognitive deterioration.Objective: In the present investigation, we studied the impact of one of the AAS compounds, i.e., 17α-methyltestosterone on acetylcholinesterase (AChE) enzyme activity in different brain parts of mice, namely, forebrain, hippocampus, midbrain, and hindbrain.Methods: The adult female mice were assigned to four experimental groups to which different doses of 17α-MT (0.5, 5.0 and 7.5 mg/kg bwt, respectively) were administrated s.c. for 30 days. A significant increase in AChE activity in forebrain and midbrain (low and medium dose treatment) suggests a reduction of cholinergic neurotransmission efficiency due to decrease in acetylcholine levels in trans-synaptic cleft. Further, concurrent reduction in AChE activity was observed in whole brain, hippocampus, and hindbrain of 17α-MT-treated mice suggests the impairment in neuronal transmission. Since the regulation of cholinergic system through acetylcholine hydrolysis has been largely attributed to AChE activity, a significant reduction in its activity may lead to stress-related anxiety, memory loss with some cognitive and behavioral aspects in the mice.Conclusion: Based on the observed results, we propose that 17α-MT, an alkylated steroid compound, has a negative impact on AChE enzyme activity in different parts of mice brain, leading to impairment in neuronal transmission.

Abstract 3: Cellular Contributions of the Circadian Clock in Atherogenesis

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Xueling Li ◽  
Ling Ruan ◽  
Austin Bentley ◽  
Stephen Haigh ◽  
Yuqing Huo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Endothelial Cells ◽  
Circadian Rhythm ◽  
Circadian Clock ◽  
Cell Types ◽  
No Production ◽  
Light Cycle ◽  
Lipid Uptake ◽  
Enhanced Production ◽  
The Impact

Atherosclerosis is a leading cause of death despite the improvements in lipid and blood pressure control. The circadian clock, a molecular network of genes and proteins that controls 24-hour timing, has emerged to have a surprising role in the control of metabolic and vascular function. Herein we examined the impact of circadian rhythm dysfunction in atherogenesis by implementation of vascular transplant and PCSK9 based approaches to induce accelerated lesion development in mice. We find that atherogenesis is exacerbated in Bmal1-KO aortic grafts immersed in the hypercholesterolemic milieu of ApoE -/- mice. To assess if atherosclerosis was ‘circadian rhythm dependent’ we subjected wild-type mice to a shortened light cycle (4L/4D) and induced atherosclerosis by intravenous injection of a human PCSK-9 adeno associated virus. Atherosclerosis in the jet-lagged PCSK-9 mice was robustly increased relative to the atherosclerosis observed in WT mice on a normal light cycle (12L/12D), providing further evidence that circadian rhythm and the circadian clock contribute to atherosclerosis. However, atherosclerosis is a complex disease that is the net result of interplay between intrinsic (vascular cells) and extrinsic mechanisms (metabolism, blood pressure, and hormones) and the importance of clock function in individual cell types is poorly understood. We found that deletion or silencing of key circadian transcription factors resulted in an enhanced inflammatory and pro-oxidant phenotype with diminished NO production and greater lipid uptake in both macrophages and endothelial cells. Loss of circadian function in smooth muscle cells similarly resulted in enhanced production of reactive oxygen species and greater cell proliferation. Surprising, the silencing of Bmal2 in endothelial cells resulted in greater lipid uptake in oxLDL treated HAEC as well as increased expression of markers of autophagy, suggesting that Bmal2 may orchestrate numerous output functions in different cell types. In conclusion, we find that the circadian clock and circadian rhythm have a profound impact on atherosclerosis, to influence vascular cell inflammatory and lipid uptake responses, and identify an unexpectedly prominent role for the side-partner of Bmal1, Bmal2.

scholarly journals Negotiating the Joint Career: Couples Adapting to Alzheimer's and Aging in Place

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Renée L. Beard ◽  
Sasha Sakhtah ◽  
Vanessa Imse ◽  
James E. Galvin
Keyword(s):  
Population Aging ◽  
Qualitative Interviews ◽  
Aging In Place ◽  
Memory Loss ◽  
Community Services ◽  
Cognitive Status ◽  
Care Practices ◽  
The Impact ◽  
With Memory ◽  
Analyze Data

To understand the impact of memory loss on aging in place, this paper investigated dyads where one spouse had been diagnosed with memory loss. In-depth qualitative interviews were conducted with ten couples (N=20). Grounded theory methods were used to collect, code, and analyze data into themes. Data revealed consensus among and between dyads that it was best to focus on living, rather than what had been or might someday be lost. Nonetheless, differences according to gender and cognitive status (e.g., diagnosed or spouse) were reported. Given population aging, identifying the impact of gender roles and social norms on the potential for aging in place with memory loss is critical. Community services and care practices must be sensitive to the ways that couples prioritized and organized their relationship prior to diagnosis in order to encourage positive patterns of care between couples, foster successful adaptation to changing needs, and support in-home arrangements as long as possible.

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