scholarly journals Targeting obesity-related inflammation in skin cancer: molecular and epigenetic insights for cancer chemoprevention by dietary phytochemicals

2016 ◽  
Vol 25 (4) ◽  
Author(s):  
Paredes-Gonzalez Ximena
Keyword(s):  
Skin Cancer ◽  
Cancer Chemoprevention ◽  
Dietary Phytochemicals

Oral nicotinamide: The role in skin cancer chemoprevention

2021 ◽  
Author(s):  
Serena Giacalone ◽  
Cristina B. Spigariolo ◽  
Paolo Bortoluzzi ◽  
Gianluca Nazzaro
Keyword(s):  
Skin Cancer ◽  
Cancer Chemoprevention

Combination of UVB Absorbing Titanium Dioxide and Quercetin Nanogel for Skin Cancer Chemoprevention

2019 ◽  
Vol 20 (6) ◽  
Author(s):  
Arvind Bagde ◽  
Ketan Patel ◽  
Arindam Mondal ◽  
Shallu Kutlehria ◽  
Nusrat Chowdhury ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Skin Cancer ◽  
Cancer Chemoprevention

scholarly journals An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 916 ◽  
Author(s):  
Salman Ul Islam ◽  
Muhammad Bilal Ahmed ◽  
Haseeb Ahsan ◽  
Mazharul Islam ◽  
Adeeb Shehzad ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Human Skin ◽  
Cancer Progression ◽  
Fruits And Vegetables ◽  
Molecular Mechanisms ◽  
In Vivo Studies ◽  
Skin Malignancy ◽  
Dietary Phytochemicals

Human skin is continuously subjected to environmental stresses, as well as extrinsic and intrinsic noxious agents. Although skin adopts various molecular mechanisms to maintain homeostasis, excessive and repeated stresses can overwhelm these systems, leading to serious cutaneous damage, including both melanoma and non-melanoma skin cancers. Phytochemicals present in the diet possess the desirable effects of protecting the skin from damaging free radicals as well as other benefits. Dietary phytochemicals appear to be effective in preventing skin cancer and are inexpensive, widely available, and well tolerated. Multiple in vitro and in vivo studies have demonstrated the significant anti-inflammatory, antioxidant, and anti-angiogenic characteristics of dietary phytochemicals against skin malignancy. Moreover, dietary phytochemicals affect multiple important cellular processes including cell cycle, angiogenesis, and metastasis to control skin cancer progression. Herein, we discuss the advantages of key dietary phytochemicals in whole fruits and vegetables, their bioavailability, and underlying molecular mechanisms for preventing skin cancer. Current challenges and future prospects for research are also reviewed. To date, most of the chemoprevention investigations have been conducted preclinically, and additional clinical trials are required to conform and validate the preclinical results in humans.

scholarly journals New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

2014 ◽  
Vol 2014 ◽  
pp. 1-18 ◽  
Author(s):  
Madhulika Singh ◽  
Shankar Suman ◽  
Yogeshwer Shukla
Keyword(s):  
Skin Cancer ◽  
Cell Cycle Progression ◽  
Molecular Mechanisms ◽  
Cancer Chemoprevention ◽  
Chemopreventive Agents ◽  
Novel Approach ◽  
Comprehensive Knowledge ◽  
Underlying Mechanisms

Skin cancer is still a major cause of morbidity and mortality worldwide. Skin overexposure to ultraviolet irradiations, chemicals, and several viruses has a capability to cause severe skin-related disorders including immunosuppression and skin cancer. These factors act in sequence at various steps of skin carcinogenesis via initiation, promotion, and/or progression. These days cancer chemoprevention is recognized as the most hopeful and novel approach to prevent, inhibit, or reverse the processes of carcinogenesis by intervention with natural products. Phytochemicals have antioxidant, antimutagenic, anticarcinogenic, and carcinogen detoxification capabilities thereby considered as efficient chemopreventive agents. Considerable efforts have been done to identify the phytochemicals which may possibly act on one or several molecular targets that modulate cellular processes such as inflammation, immunity, cell cycle progression, and apoptosis. Till date several phytochemicals in the light of chemoprevention have been studied by using suitable skin carcinogenicin vitroandin vivomodels and proven as beneficial for prevention of skin cancer. This revision presents a comprehensive knowledge and the main molecular mechanisms of actions of various phytochemicals in the chemoprevention of skin cancer.

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

2015 ◽  
Vol 373 (17) ◽  
pp. 1618-1626 ◽  
Author(s):  
Andrew C. Chen ◽  
Andrew J. Martin ◽  
Bonita Choy ◽  
Pablo Fernández-Peñas ◽  
Robyn A. Dalziell ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Randomized Trial ◽  
Cancer Chemoprevention ◽  
Phase 3

scholarly journals Nicotinamide for skin cancer chemoprevention: effects of nicotinamide on melanoma in vitro and in vivo

2020 ◽  
Vol 19 (2) ◽  
pp. 171-179 ◽  
Author(s):  
Rashi Malesu ◽  
Andrew J. Martin ◽  
J. Guy Lyons ◽  
Richard A. Scolyer ◽  
Andrew C. Chen ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Chemoprevention ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Nicotinamide is chemopreventive against keratinocyte cancers but its effects on melanoma are unknown. Clinically-achievable nicotinamide doses do not enhance melanoma viability, proliferation or invasion and enhance tumour-infiltrating lymphocytes.

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