scholarly journals Does being an infant of Gestational Diabetic Mother Affect Cerebellar Size?

2016 ◽  
Author(s):  
Ebru Yalın İmamoğlu ◽  
Tuğba Gürsoy ◽  
Selim Sancak ◽  
Güner Karatekin ◽  
Fahri Ovalı
Keyword(s):  
Diabetic Mother ◽  
Cerebellar Size

Fetal and neonatal metabolism in the pup of a canine diabetic mother. Fasting circulating fuels and neonatal glucose turnover

Diabetes ◽  
1983 ◽  
Vol 32 (4) ◽  
pp. 352-359 ◽  
Author(s):  
R. M. Kliegman ◽  
E. L. Miettinen ◽  
K. Y. Tserng
Keyword(s):  
Diabetic Mother ◽  
Glucose Turnover

Hypertrophic Obstructive Cardiomyopathy in an Infant of a Diabetic Mother

ASAIO Journal ◽  
1998 ◽  
Vol 44 (6) ◽  
pp. 845-847 ◽  
Author(s):  
Brad Robinson ◽  
Eshagh Eshaghpour ◽  
Stanford Ewing ◽  
Stephen Baumgart
Keyword(s):  
Hypertrophic Obstructive Cardiomyopathy ◽  
Diabetic Mother

TESTICULAR CHANGES IN INFANT OF DIABETIC MOTHER

The Lancet ◽  
1962 ◽  
Vol 279 (7241) ◽  
pp. 1243
Author(s):  
F. Geoghegan ◽  
M.I. Drury
Keyword(s):  
Diabetic Mother ◽  
Infant Of Diabetic Mother

scholarly journals Adverse perinatal outcome in diabetic mother treated with oral hypoglycemic agents vs. insulin

2017 ◽  
Vol 6 (6) ◽  
pp. 2252
Author(s):  
Leena Das ◽  
Bijay Kumar Meher ◽  
Sagar Parida ◽  
Deepti Damayanty Pradhan ◽  
Lucy Das ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Tertiary Care ◽  
Birth Asphyxia ◽  
Perinatal Outcomes ◽  
Educational Background ◽  
Diabetic Mother ◽  
Hypoglycemic Agents ◽  
Care Hospital ◽  
Oral Hypoglycemic Agents ◽  
Significant Difference

Background: Insulin has been the primary mode of therapy in diabetic mother for glycemic control as oral hypoglycemic agents (OHA) were initially thought to have teratogenic effect. Recent data supports the use of certain OHA; this study was designed to compare the perinatal outcomes in infants born to diabetic mother treated with insulin vs. oral hypoglycemic agents and to find out the relation of adverse perinatal events to glycemic control in both groups.Methods: This prospective observational study was conducted in a tertiary care hospital. 108 neonates born to diabetic mother between October 2014 to September 2016 were taken for study immediately after delivery after excluding the mothers who were treated with lifestyle modification and/or dietary modification alone only. 60 mothers had received insulin and 48 OHA for glycaemic control. Glycemic control was assessed by HbA1C estimation on the day of delivery. The infants were followed up in neonatal care unit for perinatal complications. Main outcome measure(s): birth weight, gestational age, respiratory problems, birth injury, birth asphyxia, congenital anomalies, hypoglycemia, hypocalcaemia, hyperbillirubinemia.Results: Out of 108 infants, 27 were born to pregestational and 81 to gestational diabetic mothers. 60(55.5%) were treated with insulin and rest with OHA, 53(49.1%) had optimal glycemic control. Both the groups had similar glycemic control in the third trimester. None of the perinatal outcomes showed significant difference between insulin and OHA group except neonatal hyperbillirubinemia. (p=0.013, RR=8 and OR=0.106). Within the optimal glycemic control (HbA1C <8), LGA has significant association with the insulin group than OHA (p=0.012, RR=2.217 and OR=4.2018).Conclusions: As compared to insulin, oral hypoglycemic agents have similar glycemic control and no adverse perinatal outcomes and can be used in pregnant mothers with diabetes mellitus from poor socioeconomic and educational background for its low cost and better patient compliance. Within the glycemic control, maternal treatment with insulin showed significant difference in LGA compared to OHA which needs further studies for validation.

scholarly journals Gestational diabetes mellitus with its maternal and foetal outcome: a clinical study

2017 ◽  
Vol 4 (4) ◽  
pp. 919 ◽  
Author(s):  
Mohan Makwana ◽  
Raj Kumar Bhimwal ◽  
Chaina Ram ◽  
S L. Mathur ◽  
Kanwar Lal ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Gestational Diabetes ◽  
Diabetic Mother ◽  
Vaginal Candidiasis ◽  
Low Socioeconomic ◽  
Infant Of Diabetic Mother ◽  
Medical College ◽  
History Of ◽  
Foetal Outcome ◽  
Sedentary Life Style

Background: Prevalence of the diabetes among pregnant women is increasing, attributable to advance maternal age, multi foetal gestation, increased body mass index, strong family history, sedentary life style, change in the diet, continued immigration. Gestational diabetes has few symptoms, commonly diagnosed by screening during pregnancy.Methods: The present study was conducted at Department of Medicine and Department of Obstetrics and Gynaecology, Dr. S.N. Medical College, Jodhpur. Rajasthan, India.Results: Out of 476 patients attending the antenatal outdoor at the Umaid Hospital, Jodhpur, Rajasthan, India. The prevalence of gestational diabetes in present study was 7.98%, Incidence of GDM found to increase with increasing age with maximum prevalence (10.71%) in more than 30 years age group, with increasing parity, low socioeconomic strata and in urban population. With maximum prevalence amongst higher parities (12.5%) in >G5 and higher). The incidence was higher with history of PIH (36.36%), family H/O DM (33.3%), GDM (12.12%), perinatal losses (15.15%), anomalous baby (9.09%), high BMI (67%). GDM complicate the normal course of pregnancy with increased incidence of PIH (36.4), Polyhydramnios (27.2%), infections like vaginal candidiasis (24.2%) and UTI (39.3%). The infant of diabetic mother had 12 (32.29%), 9 (26.47%), 11 (32.35%), 8 (23.53%) 5 (14.70%) and 3 (8.82%) of hypoglycemia, respiratory distress, macrosomia, congenital anomalies, birth injuries, polycythaemia, and hypocalcaemia respectively in diabetic mothers with suboptimal glycaemic control during pregnancy.Conclusions: GDM continues to be an important obstetrical condition with significant feto-maternal morbidity. Complications in infant of diabetic mother are more common with those mothers who had poor glycaemic control.

scholarly journals Antiapoptic Activity of Cinnamon on Some Organs of 18 Days Rat Fetuses of Diabetic Mother

2019 ◽  
Vol 16 (3) ◽  
pp. 637-648
Author(s):  
Mohamed E El-Beeh ◽  
Yousra A. Fouda ◽  
Dina A El-badry ◽  
Hassan IH El-Sayyad
Keyword(s):  
Caspase 3 ◽  
Public Health Problem ◽  
Diabetic Mother ◽  
Antidiabetic Activity ◽  
Histological Structure ◽  
Renal Tubules ◽  
Pregnant Rats ◽  
Cinnamon Extract ◽  
Histological Picture ◽  
Lingual Mucosa

Diabetes is a public health problem affected pregnant rats associated with developmental defects of their growing fetuses and histopathological abnormalities of their body organs. The traditional application of phytotherapy encourages author to develop the more safety plants which exerts antidiabetic activity and improve the histological structure. The present study aimed to evaluate the intensity of lesions induced in liver, kidney, heart and lingual mucosa of 18-day old fetuses of diabetic mother. Also, how can cinnamon-extract supplementation exert antiapoptic activity and improved the histological picture during in utero treatment. Twenty pregnant rats were used in the present work. They were categorized into four groups (n = 5); control, cinnamon extract group, diabetes, diabetes and cinnamon supplementation. Diabetes was developed by single i.p. administration of streptozotocin (60 mg/kg in citrate buffer pH 4.5 plus 100mg/kg nicotinamide). Cinnamon watery extract (300mg/kg body weight) was daily orally administrered from 6th day of gestation until 18th day of gestation. At the end of treatment, the mother was sacrificed, and their fetuses were removed and liver, kidney, heart and tongue were dissected and preserved in 10% phosphate buffered formalin pH 7.4. Also, immunohistochemistry of caspase 3 and P53 were carried out. At 18th day of gestation, maternal blood glucose levels were monitored in the investigated groups. The present findings revealed that diabetes induced damage of hepatocytes, deformation of renal tubules and renal corpuscles, fragility of myocardial muscles and damage of epithelium lining the lingual mucosa and retarded the differentiation of lingual papillae especially fungiform papillae. Increase average of apoptic cells were detected in the examined tissues of diabetic mother. Cinnamon-treatment reduced the incidence of apoptosis and improved the histological picture of liver, kidney, heart and tongue of fetuses maternally diabetic compared to the control. Image analysis revealed overexpression of immunohistochemical reaction of caspase 3 in liver, kidney and heart as well as caspase 3 and p53 in heart of fetuses of diabetic mother compared to those of diabetic mother supplemented cinnamon extract and control. The authors finally concluded that cinnamon extract showed a hypoglycaemic activity, reduced the streptozotocin associated diabetes and ameliorated the fetal liver, kidney, heart and tongue histological and immunohistochemical picture.

Infant of diabetic mother: what one needs to know?

2018 ◽  
Vol 33 (3) ◽  
pp. 482-492
Author(s):  
Venkat Reddy Kallem ◽  
Aakash Pandita ◽  
Anish Pillai
Keyword(s):  
Diabetic Mother ◽  
Infant Of Diabetic Mother

CLINICAL CONFERENCE

PEDIATRICS ◽  
1961 ◽  
Vol 28 (6) ◽  
pp. 1024-1026 ◽  
Author(s):  
Marvin Cornblath
Keyword(s):  
Diabetes Mellitus ◽  
Neonatal Mortality ◽  
Umbilical Cord ◽  
Congenital Malformations ◽  
Diabetic Mother ◽  
Morbidity And Mortality ◽  
Vernix Caseosa ◽  
Born Infant ◽  
Hands On ◽  
Diabetic Mothers

These infants are remarkable not only because, like foetal versions of Shadrach, Meshach and Abednego, they emerge at least alive from within the fiery metabolic furnace of diabetes mellitus, but because they resemble one another so closely that they might well be related. They are plump, sleek, liberally coated with vernix caseosa, fullfaced and plethoric. The umbilical cord and the placenta share in the gigantism. During their first 24 or more extra-uterine hours they lie on their backs, bloated and flushed, their legs flexed and abducted, their lightly closed hands on each side of the head, the abdomen prominent and their respiration sighing. They convey a distinct impression of having had such a surfeit of both food and fluid pressed upon them by an insistent hostess that they desire only peace so that they may recover from their excesses. And on the second day their resentment of the slightest noise improves the analogy while their trembling anxiety seems to speak of intra-uterine indescretions of which we know nothing. THUS Farquhar described the newly born infant of the diabetic mother. The purpose of this presentation is to review the information that is available concerning such infants and their difficulties. Dekaban and Baird, comparing 235 pregnancies in 48 diabetic mothers with 249 in paired nondiabetic controls, not only reaffirmed the increased intrauterine and neonatal mortality among these infants but also demonstrated an increased morbidity among the survivors. This morbidity included congenital malformations, retardation of development and epilepsy. Despite the increased morbidity and mortality, many of these infants are not sick and do well.

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