scholarly journals Quercetin-induced changes in femoral bone microstructure of adult male rabbits

10.5219/607 ◽  
2016 ◽  
Vol 10 (1) ◽  
Author(s):  
Ramona Babosová ◽  
Radoslav Omelka ◽  
Hana Ďúranová ◽  
Veronika Kováčová ◽  
Martina Lukáčová ◽  
...  
Keyword(s):  
Adult Male ◽  
Bone Microstructure ◽  
Femoral Bone ◽  
Induced Changes

scholarly journals Acrylamide-Induced Changes in Femoral Bone Microstructure of Mice

2017 ◽  
pp. 1067-1071 ◽  
Author(s):  
A. SAROCKA ◽  
R. BABOSOVA ◽  
V. KOVACOVA ◽  
R. OMELKA ◽  
M. SEMLA ◽  
...  
Keyword(s):  
Bone Microstructure ◽  
Bone Surface ◽  
Femoral Bone ◽  
Acute Effects ◽  
Trabecular Thickness ◽  
Induced Changes ◽  
The Impact ◽  
Trabecular Number ◽  
Secondary Osteons ◽  
Group 1

Acrylamide (AA) is one of the most common toxins in foods. Its effect on bone microstructure has not been investigated. The aim of our study was to analyze the impact of acute exposure to AA on femoral bone microstructure in mice. Adult animals were treated perorally with 2 doses of AA (E1 group, 1 mg/kg b.w.) in a 24-h period and with 3 doses of AA (E2 group, 1 mg/kg b.w.) in a 48-h period. Mice exposed to AA had smaller sizes of primary osteon's vascular canals. Secondary osteons were significantly smaller in mice from E2 group; however their increased number (from 38 % to 77 %) was identified in both E1 and E2 groups. In these groups, a higher number of resorption lacunae (from 100 % to 122 %) was also found. The values for bone volume, trabecular number were increased and that for trabecular separation was decreased in mice administered AA. Significantly higher value of bone surface was observed in mice from E1 group whereas trabecular thickness was increased in E2 group. The effect of AA on microstructure of compact and trabecular bone tissues is different. In our study, one dose of AA was used and acute effects of AA were investigated. Therefore, further studies are needed to study mechanisms by which AA acts on bone.

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

Biologia ◽  
2014 ◽  
Vol 69 (10) ◽  
Author(s):  
Hana Ďúranová ◽  
Monika Martiniaková ◽  
Ivana Boboňová ◽  
Radoslav Omelka ◽  
Robert Stawarz ◽  
...  
Keyword(s):  
Adult Male ◽  
Osteoporotic Fractures ◽  
Bone Diseases ◽  
Male Rats ◽  
Control Group ◽  
Femoral Bone ◽  
Negative Effects ◽  
Young Males ◽  
Male Wistar Rats ◽  
Group B

AbstractCadmium (Cd) and diazinon (DZN) are known to be environmental risk factors for various bone diseases including osteoporosis. Selenium (Se), an essential constituent of many antioxidant enzymes, has in higher concentrations negative effects on the bone. The present study was aimed to investigate possible changes in femoral bone of adult male rats after their acute and subchronic exposures to Cd, DZN and Se. A total of 30 male Wistar rats were randomized into three experimental groups. The rats in the group A (4-months-old) were injected intraperitoneally with a mixture of 2 mg CdCl2 kg−1, 20 mg DZN kg−1 and 2 mg Na2SeO3 kg−1 body weight and killed 36 h after xenobiotics had been injected. In the group B, young males (1-month-old) were administered with a combination of 30 mg CdCl2 L−1, 40 mg DZN L−1 and 5 mg Na2SeO3 L−1 in their drinking water, for 90 days. Ten 4-months-old males without toxicant supplementation served as a control group (C). After treatment period, detailed histological analysis of femoral bone was performed in each group. Our results revealed apparent osteoporotic symptoms (resorption lacunae, osteoporotic fractures) in rats from groups A and B. Moreover, histomorphometrical evaluation showed reduced bone vascularization (constricted primary osteons’ vascular canals and Haversian canals) and weakness mechanical properties of bones (smaller size of the secondary osteons) in these rats in comparison with those of the control group. Our study demonstrates for the first time that acute and subchronic co-administrations to Cd, DZN and Se induce evident manifestation characteristics of osteoporosis in male rats.

Protective role of Lycopene against Aroclor 1254-induced changes on GLUT4 in the skeletal muscles of adult male rat

2012 ◽  
Vol 36 (3) ◽  
pp. 320-328 ◽  
Author(s):  
Anne Augustine Williams ◽  
Jayaraman Selvaraj ◽  
Chinnapaiyan Srinivasan ◽  
Sampath Sathish ◽  
Parsanathan Rajesh ◽  
...  
Keyword(s):  
Adult Male ◽  
Skeletal Muscles ◽  
Protective Role ◽  
Male Rat ◽  
Aroclor 1254 ◽  
Adult Male Rat ◽  
Induced Changes

Effects of Aroclor 1254 on femoral bone metabolism in adult male Wistar rats

Toxicology ◽  
2007 ◽  
Vol 241 (3) ◽  
pp. 99-105 ◽  
Author(s):  
G. Ramajayam ◽  
M. Sridhar ◽  
S. Karthikeyan ◽  
R. Lavanya ◽  
S. Veni ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Adult Male ◽  
Wistar Rats ◽  
Femoral Bone ◽  
Aroclor 1254 ◽  
Male Wistar Rats

scholarly journals The Effect of Subacute Exposure to Acrylamide on Femoral Bone Microstructure in Laboratory Mice

2016 ◽  
Vol 25 (6) ◽  
pp. 2711-2715
Author(s):  
Anna Šarocká ◽  
Ramona Babosová ◽  
Veronika Kováčová ◽  
Patrik Šranko ◽  
Radoslav Omelka ◽  
...  
Keyword(s):  
Bone Microstructure ◽  
Laboratory Mice ◽  
Femoral Bone ◽  
Subacute Exposure

scholarly journals Monosodium glutamate-induced changes on plasma markers of pancreatic function in adult male Wistar rats

2018 ◽  
Vol 16 (2) ◽  
pp. 21
Author(s):  
H. Abdulsalam ◽  
S. Adamu ◽  
S.J. Sambo ◽  
M.A. Chiroma ◽  
J.J. Gadzama ◽  
...  
Keyword(s):  
Adult Male ◽  
Wistar Rats ◽  
Monosodium Glutamate ◽  
Pancreatic Function ◽  
Male Wistar Rats ◽  
Induced Changes ◽  
Plasma Markers
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