"Applications of biological of Azo-Schiff base ligand and its metal complexes and: A review "

2021 ◽  
Vol 8 (1) ◽  
pp. 74-80
Author(s):  
Lamia S. Ashoor ◽  
Rawa’a Abass Majeed ◽  
Rehab K. R. Al-Shemary
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Cancer Cells ◽  
Aqueous Medium ◽  
Schiff Bases ◽  
Schiff Base Ligand ◽  
Unique Feature ◽  
Biological Structures

"1998 onwards, a span reporting 1000s of studies depicts the ever-increasing Schiff bases and their complexes applicability; this study genetically tests the research of the last 20 years. The variety of these molecules structural has made them obtainable for a so broad ambit for implementations of biological. They are eminent and because of this unique feature they find their position in the quantitative and qualitative calculation of metals in the aqueous medium. It demonstrated to be prominent catalysts and showed an enjoyable effect of fluorescence. Definitively, Schiff base fissures gotten situation of a unique during bio-experiments and in vitro to develop drugs with a large number of biological structures containing parasites, fungi, viruses, cancer cells, bacteria, etc.

scholarly journals Synthesis and Spectral Studies of 4,4′-(Hydrazine-1,2-diylidenedimethylylidene)-bis-(2- methoxyphenol) and Its Transition Metal Complexes with Promising Biological Activities

2020 ◽  
Vol 32 (7) ◽  
pp. 1768-1772
Author(s):  
Anita Rani ◽  
Manoj Kumar ◽  
Hardeep Singh Tuli ◽  
Zahoor Abbas ◽  
Vinit Prakash
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Condensation Reaction ◽  
Analytical Techniques ◽  
Spectral Studies

The study describes the synthesis, characterization and biological activity of a novel Schiff base ligand and its transition metal complexes. The Schiff base ligand was obtained by a condensation reaction between 4-hydroxy-3-methoxybenzaldehyde (p-vanillin) and hydrazine hydrate using ethanol as solvent. A new series of Ni(II) and Fe(III) complexes were also derived by reaction of prepared Schiff base ligand with NiCl2 and FeCl3. Both the ligand and its metal complexes were characterized by solubility, melting point and elemental analysis. These compounds were further identified by analytical techniques, FTIR, NMR and mass spectrometry. The ligand and its transition metal complexes were also subjected to in vitro biological activities i.e. antimicrobial, antiangiogenic and DNA photo cleavage. For antimicrobial activity compounds were tested against two strains of bacteria and two strains of fungi. Different concentrations of prepared compounds were treated with fertilized chicken eggs and plasmid DNA to find out antiangiogenic and DNA photocleavage activity, respectively.

scholarly journals Synthesis, Characterization, Antimicrobial, DNA Cleavage, andIn VitroCytotoxic Studies of Some Metal Complexes of Schiff Base Ligand Derived from Thiazole and Quinoline Moiety

2014 ◽  
Vol 2014 ◽  
pp. 1-17 ◽  
Author(s):  
Nagesh Gunvanthrao Yernale ◽  
Mruthyunjayaswamy Bennikallu Hire Mathada
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Biological Activities ◽  
Artemia Salina ◽  
Spectral Studies ◽  
Antibacterial And Antifungal Activities ◽  
Pyramidal Geometry

A novel Schiff base ligandN-(4-phenylthiazol-2yl)-2-((2-thiaxo-1,2-dihydroquinolin-3-yl)methylene)hydrazinecarboxamide(L)obtained by the condensation ofN-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 2-thioxo-1,2-dihydroquinoline-3-carbaldehyde and its newly synthesized Cu(II), Co(II), Ni(II), and Zn(II) complexes have been characterized by elemental analysis and various spectral studies like FT-IR,1H NMR, ESI mass, UV-Visible, ESR, TGA/DTA, and powder X-ray diffraction studies. The Schiff base ligand(L)behaves as tridentate ONS donor and forms the complexes of type [ML(Cl)2] with square pyramidal geometry. The Schiff base ligand(L)and its metal complexes have been screenedin vitrofor their antibacterial and antifungal activities by minimum inhibitory concentration (MIC) method. The DNA cleavage activity of ligand and its metal complexes were studied using plasmid DNA pBR322 as a target molecule by gel electrophoresis method. The brine shrimp bioassay was also carried out to study thein vitrocytotoxicity properties for the ligand and its metal complexes againstArtemia salina. The results showed that the biological activities of the ligand were found to be increased on complexation.

scholarly journals Synthesis and antibacterial activity of some Schiff base complexes

2006 ◽  
Vol 71 (7) ◽  
pp. 733-744 ◽  
Author(s):  
R. Nair ◽  
A. Shah ◽  
S. Baluja ◽  
S. Chanda
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Schiff Base Complexes ◽  
Ethyl Benzene ◽  
Resistant Bacteria ◽  
Bacterial Strains ◽  
Iron And Zinc

Two Schiff bases were synthesized from raceacetophenone: 1) ADS1 4-ethyl-6-{(E)-1-[(3-nitrophenyl)imino]ethyl}benzene-1,3-diol and 2) ADS3 4-ethyl-6-[(E)-1-{(2-nitrophenyl)imino]ethyl}benzene-1,3-diol. Then their metal complexes were formed. The metals selected for the preparation of complexes were copper, nickel, iron and zinc. Hence, in total 8 metal complexes were synthesized and screened for antibacterial activity against some clinically important bacteria, such as Pseudomonas aeruginosa, Proteus vulgaris, Proteus mirabilis, Klebsiella pneumoniae and Staphylococcus aureus. The in vitro antibacterial activity was determined by the Agar Ditch technique using DMF (polar) and 1,4-dioxane (non polar) as solvents. The Schiff bases showed greater activity than theirmetal complexes; themetal complexes showed differential effects on the bacterial strains investigated and the solvent used, suggesting that the antibacterial activity is dependent on the molecular structure of the compound, the solvent used and the bacterial strain under consideration. The Schiff base ADS3 in the polar solvent DMF showed better antibacterial activity towards the investigated bacterial strains. Amongst the four metals, Zn showed the best antibacterial activity followed by Fe in 1,4-dioxane while Ni followed by Zn and Fe showed the best antibacterial activity in DMF. P. vulgaris was the most resistant bacteria.

scholarly journals Antitumor and Antimicrobial Potential of Manganese(II), Nickel(II) and Copper(II) Complexes of 4-Methoxy Benzohydrazide Derived Schiff Base Ligand

2021 ◽  
Vol 11 (1) ◽  
pp. 3249-3260
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Antimicrobial Activities ◽  
Molar Ratio ◽  
Gram Positive Bacteria ◽  
Ft Ir ◽  
Dose Dependent

Herein, we describe the synthesis and characterization of a Schiff base ligand (E)-N'-(2-hydroxybenzylidene)-4-methoxybenzohydrazide (HBMB) and its Mn(II), Ni(II), and Cu(II) metal complexes (C1-C3) respectively. The ligand HBMB was synthesized by reacting condensation of salicylaldehyde and 4-methoxy benzohydrazide in a 1:1 molar ratio. The structure of HBMB and its metal complexes (C1-C3) were evaluated by using UV-Vis, FT-IR, 1H-NMR, mass spectroscopy as well as on the basis of elemental analysis, conductivity measurements, and thermogravimetric techniques (TGA). The synthesized molecules' tumoricidal properties were performed against human breast cancer (MCF-7) and colon cancer (HT 29) cell lines. The biological results indicated that the ligand, HBMB, and metal complexes possess dose-dependent selective cytotoxicity against the tested carcinoma cells. The synthesized compounds were further evaluated for their in vitro antimicrobial activities against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli), and fungal strains (Aspergillus niger).

scholarly journals Antibacterial Co(II), Ni(II), Cu(II) and Zn(II) complexes with biacetyl-derived Schiff bases

2010 ◽  
Vol 75 (8) ◽  
pp. 1075-1084 ◽  
Author(s):  
Muhammad Imran ◽  
Mitu Liviu ◽  
Shoomaila Latif ◽  
Zaid Mahmood ◽  
Imtiaz Naimat ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Bacterial Species ◽  
Electronic Spectroscopy ◽  
Salmonella Typhi ◽  
Schiff Base Ligands ◽  
No Donor

The condensation reactions of biacetyl with orthohydroxyaniline and 2-aminobenzoic acid to form bidendate NO donor Schiff bases were studied. The prepared Schiff base ligands were further utilized for the formation of metal chelates having the general formula [ML2.2H2O] where M = Co(II), Ni(II), Cu(II) and Zn(II) and L = HL1 and HL2. These new compounds were characterized by conductance measurements, magnetic susceptibility measurements, elemental analysis, and IR, 1H-NMR and electronic spectroscopy. Both Schiff base ligands were found to have a mono-anionic bidentate nature and octahedral geometry was assigned to all metal complexes. All the complexes contained coordinated water which was lost at 141-160 ?C. These compounds were also screened for their in-vitro antibacterial activity against four bacterial species, namely; Escherichia coli, Staphylococcus aureus, Salmonella typhi and Bacillus subtillis. The metal complexes were found to have greater antibacterial activity than the uncomplexed Schiff base ligands.

scholarly journals Novel Cr(III), Co(II), Zn(II) and Cd(II) Complexes of Schiff Base Ligand Derived from Salicyaldehyde and 3,4-Diaminotoluene: Synthesis, Characterization and Biological Screening

2020 ◽  
Vol 32 (5) ◽  
pp. 1091-1096
Author(s):  
Netra Pal Singh ◽  
Uma Agarwal ◽  
Anuroop Kumar ◽  
Kaushal Kumar
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Conductivity Measurement ◽  
Chelating Agent ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Tetrahedral Geometry ◽  
Antibacterial And Antifungal

A new Schiff base ligand (L) [2,2′-((1Z,1′Z)-((4-methyl-1,2- phenylene)bis(azanylidene))bis(methanylylidene))diphenol], derived from condensation of salicyaldehyde and 3,4-diamino toluene. The synthesized ligand was used for complexation with different metal ions Cr(III), Co(II), Zn(II) and Cd(II) using a molar ratio of metal:ligand (1:1). The synthesized ligand and its metal complexes were characterized by TLC, NMR (1H & 13C), UV-visible, mass, FT-IR spectroscopies, elemental analysis, magnetic moment and conductivity measurement. On the basis of above studies the proposed structure of synthesized mononuclear metal complexes have been found to possess tetrahedral geometry while Cr(III) and Co(II) ions possess octahedral geometry. The spectral studies revealed that the synthesized ligand was acting as tetradentate chelating agent and coordinated to metal centre via deprotonated phenolate oxygen and azomethine-N atom. The biological activity of ligand and its metal complexes were screened in vitro against Gram-negative bacteria (Salmonella typhimurium and E. coli), Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and fungus (Aspergillus fumigatus) to ascertain their antibacterial and antifungal properties.

Metallkomplexe mit biologisch wichtigen Liganden, CXXXVII [1]. Halbsandwich-Komplexe mit N, O-Chelaten und Schiff-Basen von β-Aminosäuren/ Metal Complexes of Biologically Important Ligands, CXXXVII [1]. Halfsandwich Complexes with N, O-Chelates and Schiff Bases of β-Amino Acids

2001 ◽  
Vol 56 (4-5) ◽  
pp. 403-410 ◽  
Author(s):  
Daniela Koch ◽  
Winfried Hoffmüller ◽  
Kurt Polborn ◽  
Wolfgang Beck
Keyword(s):  
Amino Acids ◽  
Schiff Base ◽  
Metal Complexes ◽  
Ethyl Ester ◽  
Schiff Bases ◽  
Schiff Base Ligand ◽  
Schiff Base Complexes ◽  
Single Isomer ◽  
Bidentate Schiff Base Ligand

Abstract β-Phenylalanine forms with chloro bridged complexes the chiral N, O-chelates Cp*Ir(Cl)(NH2CH(Ph)CH2CO2) and (p-cymene)Ru(Cl)(NH2CHPhCH2CO2) as mixture of two diastereoisomers. Similarly the palladium(III) and platinum(II) complexes (Et3P)(Cl)M(NH2CH(Ph)CH2CO2) (M = Pd, Pt) were obtained. Schiff base complexes (arene)(Cl)M(O2CC(R)=N-CH(R)CH(R)CH2CO2CH3) (arene = Cp*, p-cymene; M = Ir, Ru) were synthesized from the chloro-bridged compounds, 2-oxocarboxylates and β-alanine or β-phenylalanine methylester. The Cp*Ir complex with a tridendate dianionic Schiff base generated from pyruvate and β-phenylalaninate is obtained as a single isomer. Cp*Ir(Cl) forms a complex with an N, O-bidentate Schiff base ligand from glycinate and acetylacetic ethyl ester.

scholarly journals Synthesis and Spectral Investigations of Polymeric Hydrazone Schiff Base and its Transition Metal Complexes with Promising Antimicrobial, Anti-Angeogenic and DNA Photo-Cleavage Activities

2019 ◽  
Vol 31 (10) ◽  
pp. 2331-2336 ◽  
Author(s):  
Manoj Kumar ◽  
Anita Rani ◽  
Hardeep Singh Tuli ◽  
Rajshree Khare ◽  
Vinit Parkash
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Schiff Base Ligand ◽  
Biological Activities ◽  
Free Ligand ◽  
Ft Ir ◽  
Bacteria And Fungi

This report describes the synthesis and exploration of novel Schiff base ligand in the form of a polymer (heptamer) which was prepared by reaction between 3,4-diacetyl-2,5-hexanedione and hydrazine hydrate in ethanol. On further reaction of Schiff base with transition metals ions (Co and Cu) leads to formation of its transition metal complexes. The structural identification of Schiff base ligand and its transition metal complexes were characterized by classical structural techniques like FT-IR, NMR and mass spectra. The free ligand and its transition metal complexes have been screened for in vitro biological activities against various strains of bacteria and fungi. The prepared Schiff base and its metal complexes were also screened for antiangiogenic activity. The results have shown the remarkable antimicrobial and antiangiogenic activities of the Schiff base and its metal complexes.

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