scholarly journals Esterified Anabolic Androgen-Induced Liver Injury in a Hepatitis C Virus-Positive Patient: A CaseReport

2015 ◽  
Vol 3 (3) ◽  
pp. 151-154
Author(s):  
Kyrillus S. Shohdy ◽  
Rasmia M. El Gohary
Keyword(s):  
Chronic Disease ◽  
Hepatitis C ◽  
Liver Injury ◽  
Chronic Liver ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Disease Case ◽  
Daunting Task ◽  
Wide Range ◽  
Anabolic Androgen

Background: Cases of drug induced liver injury still perplex gastroenterologists due to its wide range of presentations that mimic acute and chronic liver conditions. Moreover, matters get complicated when clinicians face the possibility of drug-induced injury in the presence of pre-existing chronic liver disease. Case: A 69 year-old male who was recently discovered to have a hepatitis C viral infection presented with acute manifestations (mixed cholangio-hepatocellular injury) not fully explained by the underlying chronic disease, we suspected an idiosyncratic reaction from an esterified anabolic androgen. His manifestations have appeared acutely after the drug intake and include acute onset of jaundice, abdominal pain, pruritus and choluria. He was improving on drug discontinuity and conservative measures during his brief hospital stay. Conclusion: The underlying chronic disease constitutes a dilemma in diagnosis of superimposed drug-induced liver injury, as the proof of causality is a daunting task. In such cases, it is tempting to link such new emerging manifestations to be a flare-up of the underlying chronic disease rather than to the drug. However, certain clues helped to point this clinical presentation towards a drug-induced liver injury

scholarly journals Kratom-Induced Cholestatic Liver Injury and Its Conservative Management

2019 ◽  
Vol 7 ◽  
pp. 232470961983613 ◽  
Author(s):  
Christopher T. Fernandes ◽  
Umair Iqbal ◽  
Sean P. Tighe ◽  
Aijaz Ahmed
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Chronic Liver Disease ◽  
The United States ◽  
Chronic Liver ◽  
Herbal Supplement ◽  
Herbal Supplements ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Analgesic Effects

Drug-induced liver injury (DILI) is a common cause of hepatotoxicity associated with prescription-based and over-the-counter exposure to medications and herbal supplements. Use of unapproved and inadequately tested herbal supplements can cause DILI. Therefore, thorough history-taking on exposure to herbal supplements must be an integral part of clinical evaluation of DILI. Kratom is an herbal supplement or remedy that has been known for its analgesic effects and has also been used for self-treatment of opiate withdrawals. A 52-year-old man was seen for evaluation of yellow discoloration of the eyes and skin. He reported taking kratom for right shoulder strain for at least a couple of months. On workup, his total bilirubin was noted to be 23.2 mg/dL, which peaked at 28.9 mg/dL. He was noted to have mild elevation of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase. Extensive laboratory tests were ordered and known causes of chronic liver disease ruled out. Magnetic resonance imaging of the abdomen was unremarkable without stigmata of portal hypertension or signs of chronic liver disease. He demonstrated no evidence of coagulopathy or hepatic encephalopathy during his illness. He underwent liver biopsy, which demonstrated histologic evidence of acute cholestatic hepatitis highly suspicious of DILI. He was advised to avoid kratom or other herbal supplements in future and prescribed ursodeoxycholic acid with significant improvement in his liver chemistries. Kratom is associated with significant liver enzymes derangements leading to DILI. Kratom is not approved for use in the United States and should be avoided.

scholarly journals Drug-induced liver injury in a chronic hepatitis C patient treated by peginterferon, ribavirin and simeprevir

2015 ◽  
Vol 45 (10) ◽  
pp. E156-E160 ◽  
Author(s):  
Akira Okajima ◽  
Kanji Yamaguchi ◽  
Hiroyoshi Taketani ◽  
Tasuku Hara ◽  
Hiroshi Ishiba ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Injury ◽  
Chronic Hepatitis C ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Cefprozil as a Cause of Drug-Induced Liver Injury Leading to Acute-on-Chronic Liver Failure

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S1350-S1351
Author(s):  
Majd Khasawneh ◽  
Zaid Imam ◽  
Fadi Odish ◽  
Mohamad Rasm Al Sibae
Keyword(s):  
Liver Injury ◽  
Liver Failure ◽  
Chronic Liver ◽  
Chronic Liver Failure ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Hepatitis C and not Hepatitis B virus is a risk factor for anti-tuberculosis drug induced liver injury

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Wan Soo Kim ◽  
Sang Soo Lee ◽  
Chang Min Lee ◽  
Hong Jun Kim ◽  
Chang Yoon Ha ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
B Virus

scholarly journals Importance of Hepatitis C Virus RNA Testing in Patients with Suspected Drug-Induced Liver Injury

2019 ◽  
Vol 64 (9) ◽  
pp. 2645-2652 ◽  
Author(s):  
Jawad Ahmad ◽  
K. Rajender Reddy ◽  
Hans L. Tillmann ◽  
Paul H. Hayashi ◽  
Naga Chalasani ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Injury ◽  
Hepatitis C Virus Rna ◽  
Suspected Drug ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Virus Rna

669 Chronic liver damage after an episode of idiosyncratic drug induced liver injury (DILI)

2006 ◽  
Vol 44 ◽  
pp. S247
Author(s):  
R.J. Andrade ◽  
M.I. Lucena ◽  
K. Pachkoria ◽  
Y. Borraz ◽  
N. Kaplowitz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Damage ◽  
Chronic Liver ◽  
Drug Induced ◽  
Chronic Liver Damage ◽  
Drug Induced Liver Injury
Sign in / Sign up

Export Citation Format

Share Document