scholarly journals Drug-induced liver injury in a chronic hepatitis C patient treated by peginterferon, ribavirin and simeprevir

2015 ◽  
Vol 45 (10) ◽  
pp. E156-E160 ◽  
Author(s):  
Akira Okajima ◽  
Kanji Yamaguchi ◽  
Hiroyoshi Taketani ◽  
Tasuku Hara ◽  
Hiroshi Ishiba ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Injury ◽  
Chronic Hepatitis C ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Prevention of drug-induced liver injury in patients with pulmonary tuberculosis and chronic hepatitis C

2019 ◽  
Author(s):  
Diana Ivanova ◽  
Sergey Borisov ◽  
Dmitriy Kudlay ◽  
Nicolay Nikolenko ◽  
Ludmila Slogotskaya ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Injury ◽  
Pulmonary Tuberculosis ◽  
Chronic Hepatitis C ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Drug Induced Pneumonitis Secondary to Treatment with Paritaprevir/Ritonavir/Ombitasvir and Dasabuvir (VIEKIRA PAK®) for Chronic Hepatitis C: Case Report of an Unexpected Life-Threatening Adverse Reaction

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Shih Yea Sylvia Wu ◽  
Bridget Faire ◽  
Edward Gane
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Kidney Injury ◽  
Complete Recovery ◽  
Final Diagnosis ◽  
Community Acquired Pneumonia ◽  
Drug Induced ◽  
First Case ◽  
Life Threatening

VIEKIRA PAK (ritonavir-boosted paritaprevir/ombitasvir and dasabuvir) is an approved treatment for compensated patients with genotype 1 (GT1) chronic hepatitis C virus (HCV) infection. This oral regimen has minimal adverse effects and is well tolerated. Cure rates are 97% in patients infected with HCV GT 1a and 99% in those with HCV GT 1b. We report the first case of life-threatening allergic pneumonitis associated with VIEKIRA PAK. This unexpected serious adverse event occurred in a 68-year-old Chinese female with genotype 1b chronic hepatitis C and Child-Pugh A cirrhosis. One week into treatment with VIEKIRA PAK without ribavirin, she was admitted to hospital with respiratory distress and acute kidney injury requiring intensive care input. She was initially diagnosed with community acquired pneumonia and improved promptly with intravenous antibiotics and supported care. No bacterial or viral pathogens were cultured. Following complete recovery, she recommenced VIEKIRA PAK but represented 5 days later with more rapidly progressive respiratory failure, requiring intubation and ventilation, inotropic support, and haemodialysis. The final diagnosis was drug induced pneumonitis.

scholarly journals Esterified Anabolic Androgen-Induced Liver Injury in a Hepatitis C Virus-Positive Patient: A CaseReport

2015 ◽  
Vol 3 (3) ◽  
pp. 151-154
Author(s):  
Kyrillus S. Shohdy ◽  
Rasmia M. El Gohary
Keyword(s):  
Chronic Disease ◽  
Hepatitis C ◽  
Liver Injury ◽  
Chronic Liver ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Disease Case ◽  
Daunting Task ◽  
Wide Range ◽  
Anabolic Androgen

Background: Cases of drug induced liver injury still perplex gastroenterologists due to its wide range of presentations that mimic acute and chronic liver conditions. Moreover, matters get complicated when clinicians face the possibility of drug-induced injury in the presence of pre-existing chronic liver disease. Case: A 69 year-old male who was recently discovered to have a hepatitis C viral infection presented with acute manifestations (mixed cholangio-hepatocellular injury) not fully explained by the underlying chronic disease, we suspected an idiosyncratic reaction from an esterified anabolic androgen. His manifestations have appeared acutely after the drug intake and include acute onset of jaundice, abdominal pain, pruritus and choluria. He was improving on drug discontinuity and conservative measures during his brief hospital stay. Conclusion: The underlying chronic disease constitutes a dilemma in diagnosis of superimposed drug-induced liver injury, as the proof of causality is a daunting task. In such cases, it is tempting to link such new emerging manifestations to be a flare-up of the underlying chronic disease rather than to the drug. However, certain clues helped to point this clinical presentation towards a drug-induced liver injury

Anticardiolipin antibody in egyptian patients with chronic hepatitis c in correlation with liver injury

2017 ◽  
Vol 15 (1) ◽  
pp. 21
Author(s):  
MahmoudH Hemida ◽  
ShaabanS Alazhari ◽  
AhmedEl Borae Kabil ◽  
Abd El HalimAssem Elsherif ◽  
MohamedAbd El Hameed Khedr
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Injury ◽  
Chronic Hepatitis C ◽  
Anticardiolipin Antibody ◽  
Egyptian Patients

Antituberculosis drug-induced liver injury in chronic hepatitis and cirrhosis

2010 ◽  
Vol 61 (4) ◽  
pp. 323-329 ◽  
Author(s):  
Wan Beom Park ◽  
Won Kim ◽  
Kook Lae Lee ◽  
Jae-Joon Yim ◽  
Moonsuk Kim ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Injury ◽  
Antituberculosis Drug ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Serum miR-122 and Human Genomic DNA in Patients With Drug-Induced Acute Liver Failure or With Chronic Hepatitis C

2011 ◽  
Vol 140 (5) ◽  
pp. S-951
Author(s):  
R Kenton Devine ◽  
Hejun Yuan ◽  
Mamta K. Jain ◽  
Corron M. Sanders ◽  
Nahid Attar ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Chronic Hepatitis C ◽  
Genomic Dna ◽  
Drug Induced ◽  
Human Genomic ◽  
Human Genomic Dna

scholarly journals Expression of Natural Killer Cell Inhibitory Receptors is Associated with Significant Liver Injury in Chronic Hepatitis C in Children

2017 ◽  
Vol 16 (4) ◽  
pp. 521-529 ◽  
Author(s):  
Anna Mania ◽  
Mariusz Kaczmarek ◽  
Paweł Kemnitz ◽  
Magdalena Figlerowicz ◽  
Jan Sikora ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Injury ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Chronic Hepatitis C ◽  
Killer Cell ◽  
Inhibitory Receptors
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