scholarly journals Quality Control Evaluation of an Ayurvedic Herbomineral Compound – Mukkadi Bidalaka

The Healer ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 52-57
Author(s):  
Sangita ◽  
Neethu Kesavan ◽  
D.B. Vaghela
Keyword(s):  
High Performance ◽  
Ph Value ◽  
Morphological Characters ◽  
Water Soluble ◽  
Physicochemical Study ◽  
Soluble Extract ◽  
Parenchyma Cells ◽  
Prismatic Crystal ◽  
Control Evaluation ◽  
Water Soluble Extract

Background: Mukkadi Bidalaka Yoga is a herbomineral compound which is claimed to be effective in Madhumehajanya Timira (Diabetic Retinopathy).  In present study, it has been used for Bidalaka Karma.Objective: Present study was designed to watch out on herbal and mineral drugs used in the preparation of Mukkadi Bidalaka Yoga to assess the quality, purity, safety and efficacy of the drug by pharmacognostical (microscopic) study, physicochemical study and chromatographic evaluation. Methods: Pharmacognostical study i.e. morphological characters, organoleptic characters and powder microscopy was done for identification and authentication of all the raw drugs. Physicochemical study and HPTLC of final product were done. Results: Pharmacognostical characters of Mukkadi Bidalaka observed under the microscope were epicarp cells and lignified stone cell of Haritaki, Trichome and lignified scleroids of Bibhitaki,  Scleroids, silica deposition of Amalaki, Parenchyma cells and starch grain of Haridra, Prismatic crystal, pitted vessels and fibers of Daruharidra, Cork cells  of Nimba, Brown content of Sariva, Trichome, oil globule of Usheera, Stone cells, scleroids, prismatic crystal and fibers of Lodhra, Cork cells , fibers  and stone cells of Vata, Parenchyma cells and oil globule of Durva, Border pitted vessels, lignified stone cells oil globule and lignified fiber passing through medullary rays of Chandana, Particles of Girika. Border pitted vessels, lignified fiber, lignified fiber passing through medullary rays of Raktachandana. Pharmaceutical evaluation of Mukkadi Bidalaka Yoga showed results loss on drying at 110C 5.85 % w/w, pH value 6.0, water soluble extract 21.60% w/w, methanol soluble extract 14.28% w/w, Ash value 3% w/w acid insoluble ash 0.39% w/w. High Performance Thin Layer Chromatography result shows 9 spots at 254 nm and 7 spots at 366 nm. Conclusion: Identification and authentication of herbal drug used in the preparation of Mukkadi Bidalaka Yoga was done. Pharmacognostical, physicochemical and HPTLC evaluation of prepared drug has been carried out.

scholarly journals Pharmacognostical and pharmaceutical analysis of Punarnava guggulu an ayurvedic polyherbal formulation

2020 ◽  
Vol 7 (6) ◽  
pp. 989
Author(s):  
Chaitali Kakadiya ◽  
Mandip Goyal ◽  
C. R. Harisha ◽  
V. J. Shukla
Keyword(s):  
Pharmaceutical Analysis ◽  
High Performance ◽  
Ph Value ◽  
Water Soluble ◽  
Soluble Extract ◽  
Polyherbal Formulation ◽  
Weight Variation ◽  
Physico Chemical ◽  
Microscopic Evaluation ◽  
Water Soluble Extract

Background: Punarnava Guggulu is a polyherbal formulation mentioned in Bhaishajya Ratnavali containing various Ayurvedic medicinal drugs and specially indicated for the treatment of Amavata and Vatarakta. For assurance of quality of herbal compounds pharmacognostical and pharmaceutical analysis should be done.   Methods: Punarnava Guggulu was subjected to microscopic evaluation for Pharmacognostical study, physiochemical analysis like hardness, weight variation, loss on drying, ash value, acid insoluble extract, pH value, water soluble extract, alcohol soluble extract, high performance thin layer chromatography (HPTLC).Results: Pharmacognostical study showed the presence of certain identifying characters of all of the ingredients of Punarnava Guggulu that is Punarnava, Erandamula, Shunthi, Guggulu, Eranda Tail, Trivruta, Danti, Guduchi, Haritaki, Bibhitaki, Amalaki, Maricha, Pippali, Chitraka, Bhallataka and Vidanga. In pharmaceutical study, preliminary physiochemical analysis showed that hardness of the Vati was 4.05 Kg/cm2, ash value 12.84% w/w, acid insoluble ash value 1.56% w/w, loss on drying 1.6% w/w, water soluble extract 35.93% w/w, alcohol soluble extract 22.14% w/w and HPTLC showed 13 spots in 254nm and 8 spots in 366nm.Conclusions: Present work was carried out to standardize the polyherbal formulation Punarnava Guggulu in terms of its identity, quality and purity. Pharmacognostical and physico-chemical observations revealed the specific characters of all active constituents in the preparation were present in it.

scholarly journals Pharmacognostical and pharmaceutical analysis of Triphala Kajjali tablet-an ayurvedic herbomineral formulation for metabolic syndrome

2021 ◽  
Vol 8 (2) ◽  
pp. 195
Author(s):  
Jaynika S. Garasia ◽  
Mandip Goyal ◽  
Harisha C. R. ◽  
Vinay J. Shukla
Keyword(s):  
Pharmaceutical Analysis ◽  
High Performance ◽  
Ph Value ◽  
Fine Powder ◽  
Water Soluble ◽  
Soluble Extract ◽  
Terminalia Bellerica ◽  
Weight Variation ◽  
Microscopic Evaluation ◽  
Water Soluble Extract

Background: Triphala is one of the most easily available and commonly used medicine which contains fine powder of three fruits viz. Terminalia chebula Retz. (Haritaki), Terminalia bellerica Roxb. (Bibhitaki) and Embilica officinalis Gaertn. (Amalaki) and is indicated as one of the drugs for management of disorders of Kapha and Meda. Due to bitter and astringent taste of Triphala in the powder form is a major complaint of the patients. So, to discover that form of Triphala, which is easy to take, effective in low dose, has long shelf life and simple to dispense is the need. For assurance of quality of herbal compounds pharmacognostical and pharmaceutical analysis should be done. Methods: Triphala Kajjali was subjected to microscopic evaluation for pharmacognostical, physiochemical analysis like hardness, weight variation, loss on drying, ash value, acid insoluble extract, pH value, water soluble extract, alcohol soluble extract and high-performance thin layer chromatography (HPTLC).Results: Pharmacognostical study showed the presence of certain identifying characters of all of the ingredients of Triphala Kajjali that is Haritaki, Bibhitaki and Amalaki. In pharmaceutical study, preliminary physiochemical analysis showed that hardness of the tablet was 2.05 kg/cm2, ash value 4.03%w/w, loss on drying 5.5%w/w, water soluble extract 5.89%w/w, alcohol soluble extract 25.96%w/w and HPTLC showed 7 spots in 254 nm and 7 spots in 366 nm.Conclusions: Pharmacognostical and physico-chemical observations revealed the specific characters of all active constituents of Triphala Kajjali and confirmed the purity and genuinity of the drug.

scholarly journals The PHARMACOGNOSTICAL, PHYSICOCHEMICAL AND HIGH-PERFORMANCE THIN LAYER CHROMATOGRAHY (HPTLC) EVALUATION OF ERANDAMULADI KALKA CHOORNA

2020 ◽  
Vol 9 (5) ◽  
Author(s):  
Swathi N. ◽  
Anup B. Thakar ◽  
Harisha C.R. ◽  
V.J. Shukla
Keyword(s):  
Pharmaceutical Analysis ◽  
High Performance ◽  
Water Soluble ◽  
Phytochemical Analysis ◽  
Low Back ◽  
Soluble Extract ◽  
Physico Chemical ◽  
Common Ailment ◽  
Back Ache ◽  
Water Soluble Extract

Introduction: Erandamuladi Niruha Basti is mentioned in Charaka Samhita which is indicated in Trika, Prishta Shoola (low back ache) and acts as Maruta Nigraha. Low backache is the most common ailment in today’s busy life. Erandamuladi Kalka used in Basti contains 9 drugs in which most of the drugs are having Ushna Veerya and are Shoolahara in nature. Method: Sookshma Choorna of Erandamuladi Kalka was evaluated for their pharmacognostic and pharmaceutical analysis. Results: Pharmacognostic study showed the presence of contents such as cluster crystal of Hapusha, starch grains of Musta, spiral vessels of Bala etc. Physico-chemical analysis showed that the loss on drying 6.28%, Ash value 13.26%, Water soluble extract 19.34%, Alcohol soluble extract 4.24%, pH 7.0 Discussion and Conclusion: The pharmacognostical and phytochemical analysis of Erandamuladi Kalka Choorna confirmed the purity and genuinity of drug, which can be espoused for laying down the standards of it. Keywords: Erandamuladi Kalka Choorna, Pharmacognostic, Phytochemical analysis, HPTLC

scholarly journals Processing and physicochemical characterization of a water-soluble extract based on Pará nut (Bertholletia excelsa) and baru nut (Dipteryx alata Vogel)

2020 ◽  
Vol 9 (8) ◽  
pp. e163984848
Author(s):  
Kamilla Soares Silva ◽  
André Luis Borges Machado ◽  
Flávio Alves da Silva ◽  
Cláudio Fernandes Cardoso ◽  
Fernanda Ferreira Freitas
Keyword(s):  
Ph Value ◽  
Physicochemical Characterization ◽  
Physical Characteristics ◽  
Water Soluble ◽  
Soluble Extract ◽  
Bertholletia Excelsa ◽  
Cubic Model ◽  
Hue Angle ◽  
Water Soluble Extract ◽  
Dipteryx Alata

Despite the nutritional and functional qualities of Pará nut  (Bertholletia excelsa) and of Baru nut (Dipteryx alata Vogel), the industrial exploitation of these two nuts is still scarce. With this, the elaboration of a water-soluble extract based on Pará and Baru nuts could be consider an alternative for the consumption of foods based on these vegetables, both little used industrially. Thus, by way of a simplex centroid experimental mixture design, this study aimed to elaborate water-soluble vegetable extracts based on Pará and Baru nuts. This study allowed evaluate the behavior of the physicochemical and physical characteristics of the processed vegetable extracts. The special cubic model obtained the best fit for the response variables, both for the physicochemical characterizations of moisture, lipid, protein, ash, carbohydrate, pH value and acidity, and for the physical characteristics of luminosity, chroma and hue angle. The results obtained showed that the model is highly predictive (all R2 > 97%). The water content directly influenced the nutritional aspects of the water-soluble extracts, where a decrease in the proportion of water in the mixture provided greater content of proximate composition. The behavior of the color parameter predicted by the model showed that variations in the proportions of the nuts concentrations changes the behavior of the luminosity indexes. The pH had higher values when there was an increase in the concentration of Pará nuts, while an increase in the proportion of baru nuts decreased the acidity of the water-soluble extract.   The mathematical models used allow to evaluate the effects of the interactions between variables and responses, highlighting their applicability in the food industry.

scholarly journals Comparative pharmacognostical and pharmaceutical evaluation of Vyaghri haritaki avaleha - an ayurvedic formulation

2015 ◽  
Vol 3 (02) ◽  
pp. 07-12
Author(s):  
Suhas A Chaudhary ◽  
K S Patel ◽  
V S Kori ◽  
S Rajagopala ◽  
C R Harisha ◽  
...  
Keyword(s):  
High Performance ◽  
Ph Value ◽  
Medical Science ◽  
Research Work ◽  
Water Soluble ◽  
Cough Reflex ◽  
Crude Drugs ◽  
Water Soluble Extract ◽  
Work Done ◽  
Layer Chromatography

Kasa is well-defined clinical condition in Brihadtrayi, clearly correlate with cough and its pathophysiology exactly correlates with the mechanism of cough reflex in contemporary medical science. Everywhere, Paediatric Outdoor Patients Department (OPD) has more than half of the total patients having respiratory tract complaints. So, to treat the disease Kasa, Vyaghri Haritaki Avaleha (VHA) was taken from Bhaishajya Ratnavali. The present work was carried out to standardize the raw drugs and finished product-VHA with comparing API standards and previous research work done in same institute to conform its identity, quality and purity of the final product. The pharmacognostical work reveals that presence of Epidermis, Cork, Pericycle, Phloem etc. from Kantakari; Lignified fibre, Stone cells etc. of Haritaki; Aluerone grains, Prismatic crystals etc. of Shunthi observed microscopically. Organoleptic features of VHA made out of the crude drugs were within the standard range. The pH value of VHA was 4.5, Water soluble extract was 71.9 %w/w, Loss on drying was 30.41 %w/w, Reducing sugar was 27.92 %w/w and High Performance Thin Layer Chromatography (HPTLC) at 254nm and 366nm resulted into 2 and 5 spots respectively

Prebiotic frozen dessert processed with water‐soluble extract of rice byproduct: Vegan and nonvegan consumers perception using preferred attribute elicitation methodology and acceptance

2021 ◽  
Vol 86 (2) ◽  
pp. 523-530
Author(s):  
Jiuliane Martins da Silva ◽  
Carlos Eduardo Barão ◽  
Erick Almeida Esmerino ◽  
Adriano Gomes Cruz ◽  
Tatiana Colombo Pimentel
Keyword(s):  
Water Soluble ◽  
Soluble Extract ◽  
Frozen Dessert ◽  
Water Soluble Extract

Activation of Selective Transcription Factors and Cytokines by Water-Soluble Extract from Lentinus lepideus

2003 ◽  
Vol 228 (6) ◽  
pp. 749-758 ◽  
Author(s):  
Mirim Jin ◽  
Hyung Jin Jung ◽  
Jeong June Choi ◽  
Hyang Jeon ◽  
Jin Hwan Oh ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Post Treatment ◽  
Water Soluble ◽  
Dependent Manner ◽  
Soluble Extract ◽  
Transient Transfection Assay ◽  
Gm Csf ◽  
Tnf Α ◽  
Water Soluble Extract

We isolated a water-soluble extract, PG101, from cultured mycelia of Lentinus lepideus. Treatment of human peripheral blood mononuclear cells (PBMCs) with PG101 increased levels of TNF-α, IL-1β, IL-10, and IL-12 by 100- to 1000-fold, whereas GM-CSF and IL-18 were activated by an order of magnitude. On the contrary, IFN-γ and IL-4 were not affected. The response to PG101 occurred in a dose- and time-dependent manner. From the human PBMCs treated with PG101, TNF-α was a first cytokine to be activated, detectable at 2 hr post-treatment followed by IL-1β at 6 hr post-treatment. IL-12 and IL-10 were the next to follow. GM-CSF and IL-18 both showed significant increases 24 hr after treatment. When PBMCs were sorted into various cell types, monocyte/macrophages, but not T and B cells, were the major target cell type responsive to PG101. Consistent with this result, the profile of cytokine expression upon PG101 treatment was comparable between PBMCs and a human promonocytic cell line (U937), whereas cell lines of T cell and myeloid origins did not respond to PG101. Data from a transient transfection assay involving specific reporter plasmids indicated that cellular transcription factor such as NF-κB, but not AP-1, was highly activated by PG101. Results from a gel retardation assay and the experiment involving a specific NF-κB inhibitor confirmed the involvement of NF-κB. Despite its significant biological effect on various cytokines, PG101 remained nontoxic in both rats and PBMCs even at a biological concentration approximately 20 times greater. PG101 demonstrates great potential as a therapeutic immune modulator.

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