scholarly journals Effectiveness of Soluble Recombinant Human Thrombomodulin in Patients with Severe Acute Pancreatitis Complicated by Disseminated Intravascular Coagulation

2019 ◽  
Vol 47 (4) ◽  
pp. 320-326
Author(s):  
Takeshi Yano ◽  
◽  
Masahiko Taniguchi ◽  
Tetsuro Shirasaka ◽  
Isao Tsuneyoshi ◽  
...  
Author(s):  
Ko Takamatsu ◽  
Yasuyoshi Kusanagi ◽  
Hideyuki Horikoshi ◽  
Takashi Nakanishi ◽  
Akinori Wada ◽  
...  

Abstract A 78-year-old man presented to our hospital with a history of 10kg weight loss within 6 months previously, and general fatigue and fever for 2 and 1 months, respectively. On hospitalization, the patient was diagnosed with polyarteritis nodosa after multiple microaneurysms were observed in the liver, kidney, pancreas, and mesenteries. He achieved remission with the administration of 1,000mg methylprednisolone for 3 days, followed by prednisolone (55mg/day). Steroids were successfully tapered with no re-elevation in inflammation. Two months after the administration of steroids, the patient complained of acute abdominal pain, and developed severe acute pancreatitis. During treatment for pancreatitis, the patient died due to septic shock and disseminated intravascular coagulation. An autopsy revealed necrotizing vasculitis in the intrapancreatic arteries and ischemia of the downstream arterioles resulting in acute pancreatitis.


Suizo ◽  
2006 ◽  
Vol 21 (5) ◽  
pp. 461-462
Author(s):  
Keisuke MAEDA ◽  
Masahiko HIROTA ◽  
Atsushi ICHIHARA ◽  
Masaki OHMURAYA ◽  
Hideo BABA

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