Comparison between Tc-99m DMSA and Renal Ultrasonography for the Evaluation of Renal Scarring and Function Loss in Children with Spina Bifida

2017 ◽  
Vol 18 (2) ◽  
pp. 76-79
Author(s):  
Ebru Ozgonenel ◽  
Isik Karalok ◽  
Emel Ceylan Gunay ◽  
Tomris Duymaz ◽  
Ibrahim Alatas ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Renal Scarring ◽  
Renal Ultrasonography ◽  
Function Loss ◽  
And Function

Unique XCI evolution in Tokudaia: initial XCI of the neo-X chromosome in Tokudaia muenninki and function loss of XIST in Tokudaia osimensis

Chromosoma ◽  
2017 ◽  
Vol 126 (6) ◽  
pp. 741-751 ◽  
Author(s):  
Hideki Zushi ◽  
Chie Murata ◽  
Shusei Mizushima ◽  
Chizuko Nishida ◽  
Asato Kuroiwa
Keyword(s):  
X Chromosome ◽  
Function Loss ◽  
And Function

scholarly journals Oxygenation of the Intraportally Transplanted Pancreatic Islet

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Thomas M. Suszynski ◽  
Efstathios S. Avgoustiniatos ◽  
Klearchos K. Papas
Keyword(s):  
Volume Fraction ◽  
Islet Cells ◽  
Thrombus Formation ◽  
Reaction Model ◽  
Diffusion Reaction ◽  
Loss Of Function ◽  
Islet Volume ◽  
Function Loss ◽  
Average Size ◽  
And Function

Intraportal islet transplantation (IT) is not widely utilized as a treatment for type 1 diabetes. Oxygenation of the intraportally transplanted islet has not been studied extensively. We present a diffusion-reaction model that predicts the presence of ananoxiccore and a largerpartly functionalcore within intraportally transplanted islets. Four variables were studied: islet diameter, islet fractional viability, external oxygen partial pressure (P) (in surrounding portal blood), and presence or absence of a thrombus on the islet surface. Results indicate that an islet with average size and fractional viability exhibits an anoxic volume fraction (AVF) of 14% and a function loss of 72% at a low externalP. Thrombus formation increased AVF to 30% and function loss to 92%, suggesting that the effect of thrombosis may be substantial. ExternalPand islet diameter accounted for the greatest overall impact on AVF and loss of function. At our institutions, large human alloislets (>200μm diameter) account for ~20% of total islet number but ~70% of total islet volume; since most of the total transplanted islet volume is accounted for by large islets, most of the intraportal islet cells are likely to be anoxic and not fully functional.

scholarly journals Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

2014 ◽  
Vol 4 (8) ◽  
pp. 608-618 ◽  
Author(s):  
Jennifer T. Crawley ◽  
Khader Hasan ◽  
H. Julia Hannay ◽  
Maureen Dennis ◽  
Catherine Jockell ◽  
...  
Keyword(s):  
Spina Bifida ◽  
Corpus Callosum ◽  
And Function

scholarly journals Urocortin II Treatment Reduces Skeletal Muscle Mass and Function Loss During Atrophy and Increases Nonatrophying Skeletal Muscle Mass and Function

Endocrinology ◽  
2003 ◽  
Vol 144 (11) ◽  
pp. 4939-4946 ◽  
Author(s):  
Richard T. Hinkle ◽  
Elizabeth Donnelly ◽  
David B. Cody ◽  
Mary Beth Bauer ◽  
Robert J. Isfort
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Function Loss ◽  
And Function

scholarly journals Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the hsa-miR-1291/LEFTY2 Axis

2021 ◽  
Vol 12 ◽  
Author(s):  
Ya-Ru Yang ◽  
Shuang Hu ◽  
Fang-Tian Bu ◽  
Hao Li ◽  
Cheng Huang ◽  
...  
Keyword(s):  
Hepatic Fibrosis ◽  
Circular Rna ◽  
Vehicle Group ◽  
Potential Biomarker ◽  
Function Loss ◽  
And Function ◽  
Pro Inflammatory Cytokines

CircRNAs (circRNAs) are commonly dysregulated in a variety of human diseases and are involved in the development and progression of cancer. However, the role of circRNAs in hepatic fibrosis (HF) is still unclear. Our previous high throughput screen revealed changes in many circRNAs in mice with carbon tetrachloride (CCl4)-induced HF. For example, circCREBBP was significantly down-regulated in primary hepatic stellate cells (HSCs) and liver tissue of HF mice induced by CCl4 compared to those in the vehicle group. Overexpression of circCREBBP with AAV8-circCREBBP in vivo prevented CCl4-induced HF worsening by reducing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) contents, liver hydroxyproline levels, collagen deposition, and levels of pro-fibrosis genes and pro-inflammatory cytokines. Furthermore, in vitro function loss and function gain analysis showed that circCREBBP inhibited HSCs activation and proliferation. Mechanically, circCREBBP acts as a sponge for hsa-miR-1291 and subsequently promotes LEFTY2 expression. In conclusion, our current results reveal a novel mechanism by which circCREBBP alleviates liver fibrosis by targeting the hsa-miR-1291/LEFTY2 axis, and also suggest that circCREBBP may be a potential biomarker for heart failure.

scholarly journals Increased Asymmetry of Trunk, Pelvis, and Hip Motion during Gait in Ambulatory Children with Spina Bifida

Symmetry ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1595
Author(s):  
Melissa A. Bent ◽  
Eva M. Ciccodicola ◽  
Susan A. Rethlefsen ◽  
Tishya A. L. Wren
Keyword(s):  
Spina Bifida ◽  
Muscle Weakness ◽  
Neural Tube Closure ◽  
Assistive Device ◽  
Trunk Motion ◽  
Lumbar Level ◽  
Hip Motion ◽  
Motor Strength ◽  
Lesion Level ◽  
And Function

Spina bifida (SB) is caused by incomplete neural tube closure and results in multiple impairments, including muscle weakness. The severity of muscle weakness depends on the neurologic lesion level. Though typically symmetric, there can be asymmetries in neurologic lesion level, motor strength, skeletal structures, and body composition that affect patients’ gait and function. Using body segment and joint motion obtained through 3D computerized motion analysis, we evaluated asymmetry and range of motion at the hip, pelvis, and trunk in the frontal and transverse planes during gait in 57 ambulatory children with SB and 48 typically developing controls. Asymmetry and range of hip, pelvis, and trunk motion in the frontal and transverse planes were significantly greater for patients with mid-lumbar and higher level lesions compared with those having sacral/low-lumbar level lesions and controls without disability (p ≤ 0.01). Crutch use decreased asymmetry of trunk rotation in mid-lumbar level patients from 10.5° to 2.6° (p ≤ 0.01). Patients with asymmetric involvement (sacral level on one side and L3-4 on the other) functioned similarly to sacral level patients, suggesting that they may be better categorized using their stronger side rather than their weaker side as is traditional. The information gained from this study may be useful to clinicians when assessing bracing and assistive device needs for patients with asymmetric SB involvement.

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