The use of manganese-enhanced MRI for the evaluation of neurodegenerative changes in a rat model of kainic acid- induced excitotoxicity

2013 ◽  
Author(s):  
Melda Apaydin ◽  
Vedat Evren ◽  
Oytun Erbas ◽  
Cem Calli ◽  
Gonul O. Peker ◽  
...  
Keyword(s):  
Kainic Acid ◽  
Rat Model ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

Manganese-enhanced MRI (ME MRI) in evaluation of the auditory pathway in an experimental rat model

2016 ◽  
Vol 30 (2) ◽  
pp. e3677 ◽  
Author(s):  
Zuohua Tang ◽  
Lingjie Wu ◽  
Zebin Xiao ◽  
Xiaoyuan Feng ◽  
Xinghuai Sun ◽  
...  
Keyword(s):  
Rat Model ◽  
Auditory Pathway ◽  
Enhanced Mri ◽  
Experimental Rat Model ◽  
Manganese Enhanced Mri

scholarly journals Manganese-enhanced MRI in a rat model of Parkinson's disease

2007 ◽  
Vol 26 (4) ◽  
pp. 863-870 ◽  
Author(s):  
Galit Pelled ◽  
Hagai Bergman ◽  
Tamir Ben-Hur ◽  
Gadi Goelman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eugene Kim ◽  
Davide Di Censo ◽  
Mattia Baraldo ◽  
Camilla Simmons ◽  
Ilaria Rosa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Plaques ◽  
Transgenic Animals ◽  
Surrounding Tissue ◽  
Rodent Models ◽  
Enhanced Mri ◽  
5Xfad Mice ◽  
Manganese Enhanced Mri

AbstractAmyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this remains a challenge due to their small size. Here, we investigated the utility of manganese-enhanced MRI (MEMRI) for visualizing plaques in transgenic rodent models of AD across two species: 5xFAD mice and TgF344-AD rats. Animals were given subcutaneous injections of MnCl2 and imaged in vivo using a 9.4 T Bruker scanner. MnCl2 improved signal-to-noise ratio but was not necessary to detect plaques in high-resolution images. Plaques were visible in all transgenic animals and no wild-types, and quantitative susceptibility mapping showed that they were more paramagnetic than the surrounding tissue. This, combined with beta-amyloid and iron staining, indicate that plaque MR visibility in both animal models was driven by plaque size and iron load. Longitudinal relaxation rate mapping revealed increased manganese uptake in brain regions of high plaque burden in transgenic animals compared to their wild-type littermates. This was limited to the rhinencephalon in the TgF344-AD rats, while it was most significantly increased in the cortex of the 5xFAD mice. Alizarin Red staining suggests that manganese bound to plaques in 5xFAD mice but not in TgF344-AD rats. Multi-parametric MEMRI is a simple, viable method for detecting amyloid plaques in rodent models of AD. Manganese-induced signal enhancement can enable higher-resolution imaging, which is key to visualizing these small amyloid deposits. We also present the first in vivo evidence of manganese as a potential targeted contrast agent for imaging plaques in the 5xFAD model of AD.

Manganese-enhanced MRI of the mouse auditory pathway

2008 ◽  
Vol 60 (1) ◽  
pp. 210-212 ◽  
Author(s):  
Takashi Watanabe ◽  
Jens Frahm ◽  
Thomas Michaelis
Keyword(s):  
Auditory Pathway ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals Diurnal Burden of Spontaneous Seizures in Early Epileptogenesis in the Post‐Kainic Acid Rat Model of Epilepsy

2021 ◽  
Author(s):  
Stephanie Mizuno ◽  
Zachery Koneval ◽  
Dannielle K. Zierath ◽  
Kevin M. Knox ◽  
H. Steve White ◽  
...  
Keyword(s):  
Kainic Acid ◽  
Rat Model ◽  
Spontaneous Seizures

scholarly journals Temporary disruption of the rat blood–brain barrier with a monoclonal antibody: A novel method for dynamic manganese-enhanced MRI

NeuroImage ◽  
2010 ◽  
Vol 50 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Hanbing Lu ◽  
Steven Demny ◽  
Yantao Zuo ◽  
William Rea ◽  
Leiming Wang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Rat Blood ◽  
Blood Brain ◽  
Enhanced Mri ◽  
Novel Method ◽  
Manganese Enhanced Mri

Reduced hippocampal manganese-enhanced MRI (MEMRI) signal during pilocarpine-induced status epilepticus: Edema or apoptosis?

2014 ◽  
Vol 108 (4) ◽  
pp. 644-652 ◽  
Author(s):  
Jackeline Moraes Malheiros ◽  
Daniele Suzete Persike ◽  
Leticia Urbano Cardoso de Castro ◽  
Talita Rojas Cunha Sanches ◽  
Lúcia da Conceição Andrade ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

scholarly journals Manganese-enhanced MRI reveals multiple cellular and vascular layers in normal and degenerated retinas

2011 ◽  
Vol 34 (6) ◽  
pp. 1422-1429 ◽  
Author(s):  
Govind Nair ◽  
Machelle T. Pardue ◽  
Moon Kim ◽  
Timothy Q. Duong
Keyword(s):  
Enhanced Mri ◽  
Manganese Enhanced Mri
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