Manganese-enhanced MRI (ME MRI) in evaluation of the auditory pathway in an experimental rat model

2016 ◽  
Vol 30 (2) ◽  
pp. e3677 ◽  
Author(s):  
Zuohua Tang ◽  
Lingjie Wu ◽  
Zebin Xiao ◽  
Xiaoyuan Feng ◽  
Xinghuai Sun ◽  
...  
Keyword(s):  
Rat Model ◽  
Auditory Pathway ◽  
Enhanced Mri ◽  
Experimental Rat Model ◽  
Manganese Enhanced Mri

Manganese-enhanced MRI of the mouse auditory pathway

2008 ◽  
Vol 60 (1) ◽  
pp. 210-212 ◽  
Author(s):  
Takashi Watanabe ◽  
Jens Frahm ◽  
Thomas Michaelis
Keyword(s):  
Auditory Pathway ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

The possible impact of noise-induced Ca 2+ -dependent activity in the central auditory pathway: A manganese-enhanced MRI study

NeuroImage ◽  
2011 ◽  
Vol 57 (1) ◽  
pp. 190-197 ◽  
Author(s):  
Moritz Gröschel ◽  
Susanne Müller ◽  
Romy Götze ◽  
Arne Ernst ◽  
Dietmar Basta
Keyword(s):  
Auditory Pathway ◽  
Enhanced Mri ◽  
Dependent Activity ◽  
Mri Study ◽  
Manganese Enhanced Mri ◽  
Central Auditory Pathway

scholarly journals Manganese-enhanced MRI in a rat model of Parkinson's disease

2007 ◽  
Vol 26 (4) ◽  
pp. 863-870 ◽  
Author(s):  
Galit Pelled ◽  
Hagai Bergman ◽  
Tamir Ben-Hur ◽  
Gadi Goelman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Enhanced Mri ◽  
Manganese Enhanced Mri

Experimental rat model of chronic cerebral hypoperfusion–reperfusion mimicking normal perfusion pressure breakthrough phenomenon

Neurocirugía ◽  
2020 ◽  
Vol 31 (5) ◽  
pp. 209-215
Author(s):  
Juan Manuel Revuelta ◽  
Álvaro Zamarrón ◽  
José Fortes ◽  
Gregorio Rodríguez-Boto ◽  
Jesús Vaquero ◽  
...  
Keyword(s):  
Rat Model ◽  
Perfusion Pressure ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
Experimental Rat Model ◽  
Normal Perfusion Pressure Breakthrough

scholarly journals In vivo multi-parametric manganese-enhanced MRI for detecting amyloid plaques in rodent models of Alzheimer’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eugene Kim ◽  
Davide Di Censo ◽  
Mattia Baraldo ◽  
Camilla Simmons ◽  
Ilaria Rosa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Plaques ◽  
Transgenic Animals ◽  
Surrounding Tissue ◽  
Rodent Models ◽  
Enhanced Mri ◽  
5Xfad Mice ◽  
Manganese Enhanced Mri

AbstractAmyloid plaques are a hallmark of Alzheimer’s disease (AD) that develop in its earliest stages. Thus, non-invasive detection of these plaques would be invaluable for diagnosis and the development and monitoring of treatments, but this remains a challenge due to their small size. Here, we investigated the utility of manganese-enhanced MRI (MEMRI) for visualizing plaques in transgenic rodent models of AD across two species: 5xFAD mice and TgF344-AD rats. Animals were given subcutaneous injections of MnCl2 and imaged in vivo using a 9.4 T Bruker scanner. MnCl2 improved signal-to-noise ratio but was not necessary to detect plaques in high-resolution images. Plaques were visible in all transgenic animals and no wild-types, and quantitative susceptibility mapping showed that they were more paramagnetic than the surrounding tissue. This, combined with beta-amyloid and iron staining, indicate that plaque MR visibility in both animal models was driven by plaque size and iron load. Longitudinal relaxation rate mapping revealed increased manganese uptake in brain regions of high plaque burden in transgenic animals compared to their wild-type littermates. This was limited to the rhinencephalon in the TgF344-AD rats, while it was most significantly increased in the cortex of the 5xFAD mice. Alizarin Red staining suggests that manganese bound to plaques in 5xFAD mice but not in TgF344-AD rats. Multi-parametric MEMRI is a simple, viable method for detecting amyloid plaques in rodent models of AD. Manganese-induced signal enhancement can enable higher-resolution imaging, which is key to visualizing these small amyloid deposits. We also present the first in vivo evidence of manganese as a potential targeted contrast agent for imaging plaques in the 5xFAD model of AD.

Therapeutic effect of sunitinib on diabetes mellitus related ovarian injury: an experimental rat model study

2015 ◽  
Vol 31 (5) ◽  
pp. 388-391 ◽  
Author(s):  
Oytun Erbas ◽  
Halil Gursoy Pala ◽  
Emel Ebru Pala ◽  
Burcu Artunc Ulkumen ◽  
Levent Akman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Therapeutic Effect ◽  
Rat Model ◽  
Model Study ◽  
Experimental Rat Model
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