scholarly journals Direct immunofluorescence studies in lichen planus

2019 ◽  
Author(s):  
Supriya Jain ◽  
Vijaya Basavaraj
Keyword(s):  
Lichen Planus ◽  
Direct Immunofluorescence ◽  
Immunofluorescence Studies

scholarly journals Lichen Planus Pemphigoides Induced by Enalapril: A Case Report and a Review of Literature

2017 ◽  
Vol 9 (3) ◽  
pp. 217-224 ◽  
Author(s):  
Woranit Onprasert ◽  
Kumutnart Chanprapaph
Keyword(s):  
Lichen Planus ◽  
Early Recognition ◽  
Case Reports ◽  
Direct Immunofluorescence ◽  
Drug Induced ◽  
First Case ◽  
Bullous Dermatosis ◽  
Culprit Drug ◽  
History Of ◽  
Hands And Feet

Lichen planus pemphigoides (LPP) is a rare autoimmune bullous dermatosis. The clinical presentation of LPP may mimic bullous pemphigoid making the diagnosis difficult. A thorough clinical, histopathological, and immunological evaluation is essential for the diagnosis of LPP. The etiology is largely idiopathic; however, there are several case reports of drug-induced LPP. We report an 81-year-old Thai woman with underlying hypertension and type 2 diabetes mellitus who presented with a 4-week history of multiple tense bullae initially on the hands and feet that subsequently expanded to the trunk and face. Enalapril was commenced to control hypertension. The histopathology and direct immunofluorescence were compatible with LPP. Circulating anti-basement antibodies BP180 was also positive. The patient was treated with topical corticosteroid with a modest effect. Enalapril was discontinued and complete resolution of LPP occurred within 12 weeks. There was no recurrence after a 1-year follow-up period. To the best of our knowledge, we present the first case of enalapril-induced LPP. Early recognition and prompt discontinuation of the culprit drug allow resolution of the disease. Medication given for LPP alone, without cessation of the offending drug, may not change the course of this condition.

scholarly journals HISTOPATHOLOGICAL AND IMMUNOFLUORESCENT STUDIES IN CERTAIN SKIN DISORDERS

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Rekha S ◽  
Vineet Kumar ◽  
Vanita Kumar ◽  
R D Mehta
Keyword(s):  
Lichen Planus ◽  
Dermatitis Herpetiformis ◽  
Direct Immunofluorescence ◽  
Skin Disorders ◽  
Immunological Mechanism ◽  
Medical College ◽  
Skin Biopsy Specimen ◽  
Immunofluorescent Technique ◽  
Skin Biopsies

Background: This study was an attempt to evaluate the role of direct immunofluorescent technique to demonstrate the immunoglobulins in certain skin disorders, which are likely to have immunological mechanism in their pathogenesis. Methods: This study was carried out in department of Pathology, Sardar Patel Medical College & Associated group of Hospitals, Bikaner. This study was hospital based study on skin biopsy specimen recieved in the department of Pathology during the study period. Results: On immunofluorescent studies of these skin biopsies, 12 out of 16 cases of pemphigus were positive for fluorescence was intracellular area in epidermis. In lichen planus  5 out of 7 cases were positive for fluorescence and commonest site was dermo-epideremal junction. In dermatis-herpatiformis 2 out of 3cases were positive for fluorescence and commonest site was dermo-epideremal junction. IgG was commonest type of immunoglobulin’s demonstrate in 12 out of 16 cases of pemphigus followed by IgM (5 cases), IgA(1cases). In lichen planus  IgM was commonest type of immunoglobulin’s demonstrate in 5 out of 7 cases of pemphigus followed by IgG (3 cases), IgA(1cases). In dermatitis herpatiformis IgA was commonest type of immunoglobulin’s demonstrate in 2 out of 3 cases of pemphigus followed by IgM (1 cases). Conclusion: We conclude that the demonstration of immunoglobulins in skin biopsies by direct fluorescent technique is a quite useful adjunct in diagnostic confirmation of pemphigus, lichen planus and dermatitis herpetiformis. Keywords: Direct immunofluorescence, Pemphigus, Histopathology.

Direct immunofluorescence study in patients with lichen planus

2007 ◽  
Vol 46 (12) ◽  
pp. 1237-1241 ◽  
Author(s):  
Kanokvalai Kulthanan ◽  
Sukhum Jiamton ◽  
Supenya Varothai ◽  
Sumruay Pinkaew ◽  
Puan Sutthipinittharm
Keyword(s):  
Lichen Planus ◽  
Direct Immunofluorescence ◽  
Immunofluorescence Study

scholarly journals Direct Immunofluorescence Studies in Alopecia Areata and Male Pattern Alopecia

1979 ◽  
Vol 73 (5) ◽  
pp. 317-320 ◽  
Author(s):  
Jean-Claude Bystryn ◽  
Norman Orentreich ◽  
Fernando Stengel
Keyword(s):  
Alopecia Areata ◽  
Direct Immunofluorescence ◽  
Immunofluorescence Studies ◽  
Male Pattern
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