scholarly journals Clinical significance of granulation pattern in corticotroph pituitary adenomas

2018 ◽  
Author(s):  
Sema Ciftci Dogansen ◽  
Bilge Bilgic ◽  
Gulsah Yenidunya Yalin ◽  
Seher Tanrikulu ◽  
Sema Yarman
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Granulation Pattern

Galanin in human pituitary adenomas: frequency and clinical significance

2002 ◽  
Vol 56 (6) ◽  
pp. 825-825
Author(s):  
B. Leung ◽  
T. P. Lismaa ◽  
K.-C. Leung ◽  
Y. J. Hort ◽  
J. Turner ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Human Pituitary ◽  
Human Pituitary Adenomas

scholarly journals Different Volumetric Measurement Methods for Pituitary Adenomas and Their Crucial Clinical Significance

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chi-Cheng Chuang ◽  
Shinn-Yn Lin ◽  
Ping-Ching Pai ◽  
Jiun-Lin Yan ◽  
Cheng-Hong Toh ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Measurement Methods ◽  
Volumetric Measurement

scholarly journals Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas

2001 ◽  
Vol 33 (3) ◽  
pp. 111-116 ◽  
Author(s):  
Do-Hyun Nam ◽  
Sang-Yong Song ◽  
Kyoungsook Park ◽  
Mi Hyun Kim ◽  
Yeon-Lim Suh ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Molecular Genetic ◽  
Genetic Changes

Preoperative prediction of granulation pattern subtypes in GH‐secreting pituitary adenomas

2021 ◽  
Author(s):  
Lijun Heng ◽  
Xiaoyan Liu ◽  
Dong Jia ◽  
Wei Guo ◽  
Shuo Zhang ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Preoperative Prediction ◽  
Granulation Pattern

Radiomics model predicts granulation pattern in growth hormone-secreting pituitary adenomas

Pituitary ◽  
2020 ◽  
Vol 23 (6) ◽  
pp. 691-700
Author(s):  
Yae Won Park ◽  
Yunjun Kang ◽  
Sung Soo Ahn ◽  
Cheol Ryong Ku ◽  
Eui Hyun Kim ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenomas ◽  
Granulation Pattern

Galanin in human pituitary adenomas: frequency and clinical significance

2002 ◽  
Vol 56 (3) ◽  
pp. 397-403 ◽  
Author(s):  
Betty Leung ◽  
Tiina P. Lismaa ◽  
Kin-Chuen Leung ◽  
Yvonne J. Hort ◽  
Jennifer Turner ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Human Pituitary ◽  
Human Pituitary Adenomas

scholarly journals Pituitary adenomas: Clinical significance and genetic syndromes

2002 ◽  
Vol 10 (3) ◽  
pp. 179-179
Author(s):  
Svetozar Damjanovic ◽  
Milan Petakov ◽  
Vera Popovic ◽  
Marina Nikolic-Djurovic ◽  
Mirjana Doknic ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Genetic Syndromes

scholarly journals Somatostatin receptor ligands and resistance to treatment in pituitary adenomas

2014 ◽  
Vol 52 (3) ◽  
pp. R223-R240 ◽  
Author(s):  
Daniel Cuevas-Ramos ◽  
Maria Fleseriu
Keyword(s):  
Pituitary Adenomas ◽  
Somatostatin Receptor ◽  
Somatostatin Receptors ◽  
Receptor Expression ◽  
Biologically Active ◽  
Imaging Features ◽  
Receptor Ligands ◽  
Somatostatin Receptor Ligands ◽  
Granulation Pattern ◽  
Acth Secreting

Somatostatin (SST), an inhibitory polypeptide with two biologically active forms SST14 and SST28, inhibits GH, prolactin (PRL), TSH, and ACTH secretion in the anterior pituitary gland. SST also has an antiproliferative effect inducing cell cycle arrest and apoptosis. Such actions are mediated through five G-protein-coupled somatostatin receptors (SSTR): SSTR1–SSTR5. In GH-secreting adenomas, SSTR2 expression predominates, and somatostatin receptor ligands (SRLs; octreotide and lanreotide) directed to SSTR2 are presently the mainstays of medical therapy. However, about half of patients show incomplete biochemical remission, but the definition of resistanceper seremains controversial. We summarize here the determinants of SRL resistance in acromegaly patients, including clinical, imaging features as well as molecular (mutations, SSTR variants, and polymorphisms), and histopathological (granulation pattern, and proteins and receptor expression) predictors. The role of SSTR5 may explain the partial responsiveness to SRLs in patients with adequate SSTR2 density in the cell membrane. In patients with ACTH-secreting pituitary adenomas, i.e. Cushing's disease (CD), SSTR5 is the most abundant receptor expressed and tumors show low SSTR2 density due to hypercortisolism-induced SSTR2 down-regulation. Clinical studies with pasireotide, a multireceptor-targeted SRL with increased SSTR5 activity, lead to approval of pasireotide for treatment of patients with CD. Other SRL delivery modes (oral octreotide), multireceptor-targeted SRL (somatoprim) or chimeric compounds targeting dopamine D2 receptors and SSTR2 (dopastatin), are briefly discussed.

The clinical significance of MIB-1 labeling index in pituitary adenomas

Pituitary ◽  
2010 ◽  
Vol 13 (4) ◽  
pp. 337-344 ◽  
Author(s):  
Geeta Chacko ◽  
Ari G. Chacko ◽  
Kalman Kovacs ◽  
Bernd W. Scheithauer ◽  
Sunithi Mani ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Labeling Index ◽  
Mib 1

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

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