scholarly journals Pituitary adenomas: Clinical significance and genetic syndromes

2002 ◽  
Vol 10 (3) ◽  
pp. 179-179
Author(s):  
Svetozar Damjanovic ◽  
Milan Petakov ◽  
Vera Popovic ◽  
Marina Nikolic-Djurovic ◽  
Mirjana Doknic ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Genetic Syndromes

Galanin in human pituitary adenomas: frequency and clinical significance

2002 ◽  
Vol 56 (6) ◽  
pp. 825-825
Author(s):  
B. Leung ◽  
T. P. Lismaa ◽  
K.-C. Leung ◽  
Y. J. Hort ◽  
J. Turner ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Human Pituitary ◽  
Human Pituitary Adenomas

scholarly journals Different Volumetric Measurement Methods for Pituitary Adenomas and Their Crucial Clinical Significance

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chi-Cheng Chuang ◽  
Shinn-Yn Lin ◽  
Ping-Ching Pai ◽  
Jiun-Lin Yan ◽  
Cheng-Hong Toh ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Measurement Methods ◽  
Volumetric Measurement

scholarly journals Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas

2001 ◽  
Vol 33 (3) ◽  
pp. 111-116 ◽  
Author(s):  
Do-Hyun Nam ◽  
Sang-Yong Song ◽  
Kyoungsook Park ◽  
Mi Hyun Kim ◽  
Yeon-Lim Suh ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Molecular Genetic ◽  
Genetic Changes

scholarly journals Clinical significance of granulation pattern in corticotroph pituitary adenomas

2018 ◽  
Author(s):  
Sema Ciftci Dogansen ◽  
Bilge Bilgic ◽  
Gulsah Yenidunya Yalin ◽  
Seher Tanrikulu ◽  
Sema Yarman
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Granulation Pattern

Galanin in human pituitary adenomas: frequency and clinical significance

2002 ◽  
Vol 56 (3) ◽  
pp. 397-403 ◽  
Author(s):  
Betty Leung ◽  
Tiina P. Lismaa ◽  
Kin-Chuen Leung ◽  
Yvonne J. Hort ◽  
Jennifer Turner ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Human Pituitary ◽  
Human Pituitary Adenomas

The clinical significance of MIB-1 labeling index in pituitary adenomas

Pituitary ◽  
2010 ◽  
Vol 13 (4) ◽  
pp. 337-344 ◽  
Author(s):  
Geeta Chacko ◽  
Ari G. Chacko ◽  
Kalman Kovacs ◽  
Bernd W. Scheithauer ◽  
Sunithi Mani ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Pituitary Adenomas ◽  
Labeling Index ◽  
Mib 1

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

Ultrastructural comparison of prolactin adenomas of pituitary in men and women

1988 ◽  
Vol 46 ◽  
pp. 346-347
Author(s):  
R.C. Caughey ◽  
U.P. Kalyan-Raman
Keyword(s):  
Endoplasmic Reticulum ◽  
Electron Microscope ◽  
Phosphate Buffer ◽  
Pituitary Adenomas ◽  
Osmium Tetroxide ◽  
Secretory Granules ◽  
Uranyl Acetate ◽  
En Bloc ◽  
Men And Women ◽  
Transmission Electron

Prolactin producing pituitary adenomas are ultrastructurally characterized by secretory granules varying in size (150-300nm), abundance of endoplasmic reticulum, and misplaced exocytosis. They are also subclassified as sparsely or densely granulated according to the amount of granules present. The hormone levels in men and women vary, being higher in men; so also the symptoms vary between both sexes. In order to understand this variation, we studied 21 prolactin producing pituitary adenomas by transmission electron microscope. This was out of a total of 80 pituitary adenomas. There were 6 men and 15 women in this group of 21 prolactinomas.All of the pituitary adenomas were fixed in 2.5% glutaraldehyde, rinsed in Millonig's phosphate buffer, and post fixed with 1% osmium tetroxide. They were then en bloc stained with 0.5% uranyl acetate, rinsed with Walpole's non-phosphate buffer, dehydrated with graded series of ethanols and embedded with Epon 812 epoxy resin.

Fine Structural Classification of Chromophobe Adenomas of the Human Pituitary Gland

1975 ◽  
Vol 33 ◽  
pp. 378-379
Author(s):  
K. Kovacs ◽  
E. Horvath
Keyword(s):  
Pituitary Adenomas ◽  
Secretory Activity ◽  
Microscopic Investigation ◽  
Uranyl Acetate ◽  
Electron Microscopic Investigation ◽  
Electron Microscopic ◽  
Human Pituitary ◽  
Cytoplasmic Staining ◽  
Human Pituitary Gland ◽  
Microscopic Features

Chromophobe pituitary adenomas arise from adenohypophysial cells and fail to exhibit cytoplasmic staining with conventional acid or basic dyes by light microscopy. The aim of the present work was to study the electron microscopic features of these tumors, to separate them into distinct entities and to correlate their fine structural appearances with secretory activity.Among 48 surgically removed various pituitary adenomas 30 tumors were found which, based on the tinctorial characteristics of the cytoplasm, corresponded to chromophobe adenomas. For electron microscopic investigation pieces of these tumors were fixed in 2.5 per cent glutaraldehyde in Sorensen's buffer, post fixed in 1 per cent osmium tetroxide in Millonig's buffer, dehydrated in graded ethanol and embedded in Epon 812. Ultrathin sections were stained with uranyl acetate and lead citrate.By electron microscopy it was possible to separate chromophobe adenomas into 3 distinct entities: 1) adenomas consisting of sparsely granulated growth hormone cells (7 cases).

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