scholarly journals The role of frozen-section in the surgical management of patients with endometrial intraepithelial neoplasia

2015 ◽  
Author(s):  
Mehmet Coskun Salman ◽  
Derman Basaran ◽  
Alp Usubutun ◽  
Nejat Ozgul ◽  
Kunter Yuce
Keyword(s):  
Surgical Management ◽  
Frozen Section ◽  
Intraepithelial Neoplasia ◽  
Endometrial Intraepithelial Neoplasia

Role of Intraoperative Frozen Section in Surgical Management of Ovarian Masses

2016 ◽  
Vol 4 (2) ◽  
pp. 65-68
Author(s):  
Romana Idrees ◽  
Zakia Sheikh ◽  
Uzma Chishti ◽  
Tahira Y Malik ◽  
Aliya B Aziz ◽  
...  
Keyword(s):  
Surgical Management ◽  
Frozen Section ◽  
Intraoperative Frozen Section ◽  
Ovarian Masses

scholarly journals MOLECULAR PROFILES OF ENDOMETRIAL HYPERPLASIA AND ENDOMETRIAL INTRAEPITHELIAL NEOPLASIA

2018 ◽  
Vol 14 (2) ◽  
pp. 76-81 ◽  
Author(s):  
S. A. Levakov ◽  
N. A. Sheshukova ◽  
A. G. Kedrova ◽  
A. S. Fedotova ◽  
E. A. Obukhova
Keyword(s):  
Endometrial Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Control Group ◽  
Tumor Proliferation ◽  
Invasive Growth ◽  
Inhibitors Of Apoptosis ◽  
Endometrial Intraepithelial Neoplasia ◽  
Atypical Cells ◽  
Molecular Profiles

Objective: to assess molecular profiles of endometrial hyperplasia and endometrial intraepithelial neoplasia.Materials and methods. We conducted a retrospective study that included 77 patients with a morphologically verified hyperplastic process in the endometrium. Of them, 34 patients had endometrial hyperplasia and 33 patients had endometrial intraepithelial neoplasia. The control group comprised 30 women with no endometrial disorders according to the results of histological examination.Results. Patients with endometrial intraepithelial neoplasia are at high risk of developing cancer. High angiogenic activity, pronounced vascularization, and endometrial hypoxia are believed to be important risk factors contributing to tumor proliferation and transformation. The expression of inhibitors of apoptosis, such as survivin and Bcl-2, is usually increased in atypical cells, which may indicate their involvement in malignant transformation of cells and tumor invasive growth.Conclusion. Our findings confirm the important role of survivin and Bcl-2 in hyperplastic processes in the endometrium.

scholarly journals Surgical management of suspected gallbladder cancer: The role of intraoperative frozen section for diagnostic confirmation

2021 ◽  
Author(s):  
Benjamin K. Y. Chan ◽  
Lucia Carrion‐Alvarez ◽  
Rebecca Telfer ◽  
Adeeb H. Rehman ◽  
Nicholas Bird ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Surgical Management ◽  
Frozen Section ◽  
Intraoperative Frozen Section

The Role of Fine-Needle Aspiration and Intraoperative Frozen Section in the Surgical Management of Solitary Thyroid Nodules

Surgery Today ◽  
2002 ◽  
Vol 32 (10) ◽  
pp. 857-861 ◽  
Author(s):  
Simon D. Duek ◽  
David Goldenberg ◽  
Shai Linn ◽  
Michael M. Krausz ◽  
Dan D. Hershko
Keyword(s):  
Surgical Management ◽  
Fine Needle Aspiration ◽  
Thyroid Nodules ◽  
Frozen Section ◽  
Needle Aspiration ◽  
Fine Needle ◽  
Intraoperative Frozen Section

scholarly journals Role of intraoperative frozen section in the diagnosis of ovarian tumors: Experience at Gujarat Cancer and Research Institute

2016 ◽  
Author(s):  
Ruchi Arora
Keyword(s):  
Surgical Management ◽  
Ovarian Neoplasms ◽  
Frozen Section ◽  
Ovarian Tumors ◽  
Borderline Tumors ◽  
Intraoperative Frozen Section ◽  
Histopathologic Diagnosis ◽  
Frozen Section Diagnosis ◽  
Line Of Therapy

Background: The surgical management of ovarian tumors depends on their correct categorization as benign, borderline or malignant. Ovarian neoplasms are an important cause of morbidity and mortality in women. This study was undertaken to evaluate the accuracy of intra-operative frozen section in the diagnosis of various categories of ovarian neoplasms. Methods: Intraoperative frozen section diagnosis was retrospectively evaluated in 125 patients with suspected ovarian neoplasms who underwent surgery as primary line of therapy at our institution. This was compared with the final histopathologic diagnosis on paraffin sections. Results: In 125 patients frozen section report had a sensitivity of 100%, 95.55% and 50% for benign, malignant and borderline tumors respectively. The corresponding specificities were 92.45%, 98.75% and 99.14% respectively. The overall accuracy of frozen section diagnosis was 95.2%. The majority of cases of disagreement were in the mucinous and borderline tumors. Conclusion: Intraoperative frozen section has high accuracy in the diagnosis of suspected ovarian neoplasms. It is a valuable tool to guide the surgical management of these patients and should be routinely used in all major oncology centers.

scholarly journals Role of frozen section in surgical management of ovarian neoplasm

2020 ◽  
Vol 9 (1) ◽  
pp. 13 ◽  
Author(s):  
Tony Augestine ◽  
Saphina Palakkan ◽  
MK Valsan ◽  
KP Abdul Vahab ◽  
LekhaK Nair
Keyword(s):  
Surgical Management ◽  
Frozen Section ◽  
Ovarian Neoplasm

Role of Fine-Needle Aspiration Biopsy and Frozen Section Analysis in the Surgical Management of Thyroid Tumors

2001 ◽  
Vol 8 (2) ◽  
pp. 92-100 ◽  
Author(s):  
Ari D. Brooks ◽  
Ashok R. Shaha ◽  
Wilson DuMornay ◽  
Andrew G. Huvos ◽  
Maureen Zakowski ◽  
...  
Keyword(s):  
Surgical Management ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Frozen Section ◽  
Needle Aspiration ◽  
Thyroid Tumors ◽  
Fine Needle ◽  
Frozen Section Analysis ◽  
Section Analysis

scholarly journals Role of frozen section in the surgical management of indeterminate thyroid nodules

Gland Surgery ◽  
2019 ◽  
Vol 8 (S2) ◽  
pp. S112-S117
Author(s):  
Haythem Najah ◽  
Christophe Tresallet
Keyword(s):  
Surgical Management ◽  
Thyroid Nodules ◽  
Frozen Section

Possible Role of PTEN expression in discriminating Benign Endometrial hyperplasia from Atypical Hyperplasia/Endometrial Intraepithelial Neoplasia in a series of Egyptian Patients

2021 ◽  
Vol 17 ◽  
Author(s):  
Nevine I. Ramzy ◽  
Wael S. Ibrahiam ◽  
Hanan H.M. Ali ◽  
Mona M.A. Akle ◽  
Sara E. Khalifa
Keyword(s):  
Endometrial Hyperplasia ◽  
Intraepithelial Neoplasia ◽  
Atypical Hyperplasia ◽  
Pten Expression ◽  
Histological Evaluation ◽  
Type I ◽  
Pten Protein ◽  
Endometrial Intraepithelial Neoplasia ◽  
Egyptian Patients

Background: Endometrial hyperplasia represents a heterogeneous group of lesions in response to the unopposed growth-promoting action of estrogen. WHO classified endometrial hyperplastic lesions into Benign Hyperplasia (BH) and atypical hyperplasia/ endometrial intraepithelial neoplasia AH/EIN. Phosphatase and tensin homolog (PTEN) is one of the earliest and most common genetic abnormalities detected in endometrioid adenocarcinoma (type I) and even in its precursors. This study aimed at histological evaluation of hyperplastic endometrial lesions according to WHO 2014 and investigating the role of PTEN expression in highlighting the precancerous group (AH/EIN). Patient and Method: This study included a series of 70 Egyptian patients suffered from hyperplastic endometrial lesions. They were previously diagnosed according to WHO1994 schema simple endometrial hyperplasia without atypia (n=18), simple endometrial hyperplasia with atypia (n=2), complex hyperplasia without atypia (n=25), complex hyperplasia with atypia (n=5) and hyperplastic endometrial polyps (n=20). Results: Cases were histologically re-evaluated according to WHO 2014 classification; BH (62 cases) and eight cases of AH/EIN. A significant difference in PTEN expression (regarding percentage and intensity of staining) in relation to histopathological diagnosis was detected (P-value 0.02 and <0.05, respectively). The sensitivity and specificity of the absence of diffuse PTEN protein expression (>50%) to detect AH/EIN were 100% and 77.4%, respectively. Conclusion: Diffuse, dim or loss of immunohistochemical expression of PTEN protein is significantly correlated with the new WHO classification segregation of AH/EIN as precancerous lesions. However, further studies are recommended to confirm this association.

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