scholarly journals Korean Red Ginseng Saponin Fraction Downregulates Proinflammatory Mediators in LPS Stimulated RAW264.7 Cells and Protects Mice against Endotoxic Shock

2012 ◽  
Vol 36 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Taddessee Yayeh ◽  
Kun-Ho Jung ◽  
Hye-Yoon Jeong ◽  
Ji-Hoon Park ◽  
Yong-Bum Song ◽  
...  
Keyword(s):  
Endotoxic Shock ◽  
Raw264.7 Cells ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Saponin ◽  
Proinflammatory Mediators ◽  
Saponin Fraction

scholarly journals Red Ginseng Saponin Fraction A Isolated from Korean Red Ginseng by Ultrafiltration on the Porcine Coronary Artery

2011 ◽  
Vol 35 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Young-Hyun Jung ◽  
Kwang-Yeol Park ◽  
Jin-Hong Jeon ◽  
Yi-Seong Kwak ◽  
Yong-Bum Song ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Porcine Coronary Artery ◽  
Ginseng Saponin ◽  
Saponin Fraction

scholarly journals Korean Red Ginseng Saponin Fraction Rich in Ginsenoside-Rb1, Rc and Rb2 Attenuates the Severity of Mouse Collagen-Induced Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Mehari Endale ◽  
Eun Ju Im ◽  
Joo Young Lee ◽  
Sung Dae Kim ◽  
Taddesse Yayeh ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Combined Therapy ◽  
Cartilage Damage ◽  
Serum Antibody ◽  
Ginsenoside Rb1 ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Saponin ◽  
Anti Inflammatory ◽  
Saponin Fraction

Despite a multitude of reports on anti-inflammatory properties of ginseng extracts or individual ginsenosides, data on antiarthritic effect of ginseng saponin preparation with mixed ginsenosides is limited. On the other hand, a combined therapy of safe and inexpensive plant-derived natural products such as ginsenosides can be considered as an alternative to treat arthritis. Our previousin vitrodata displayed a strong anti-inflammatory action of red ginseng saponin fraction-A (RGSF-A). We, herein, report a marked antiarthritic property of RGSF-A rich in ginsenoside Rb1, Rc, and Rb2. Collagen-induced arthritic (CIA) mice were treated with RGSF-A or methotrexate (MTX) for 5 weeks. Joint pathology, serum antibody production and leukocye activation, cytokine production in the circulation, lymph nodes, and joints were examined. RGSF-A markedly reduced severity of arthritis, cellular infiltration, and cartilage damage. It suppressed CD3+/CD69+, CD4+/CD25+, CD8+T-cell, CD19+, B220/CD23+B-cell, MHCII+/CD11c+, and Gr-1+/CD11b+cell activations. It further suppressed anti-CII- or anti-RF-IgG/IgM, TNF-α, IL-1β, IL-17, and IL-6 secretions but stimulated IL-10 levels in the serum, joint, or splenocyte. RGSF-A attenuated arthritis severity, modified leukocyte activations, and restored cytokine imbalances, suggesting that it can be considered as an antiarthritic agent with the capacity to ameliorate the immune and inflammatory responses in CIA mice.

scholarly journals Signaling Pathways Associated with Macrophage-Activating Polysaccharide Isolated from Korea Red Ginseng

2021 ◽  
Vol 11 (15) ◽  
pp. 7111
Author(s):  
Jie Gao ◽  
Sullim Lee ◽  
Ji-Hwan Lee ◽  
Ki-Sung Kang ◽  
Myoung-Sook Shin
Keyword(s):  
Nitric Oxide ◽  
Raw264.7 Cells ◽  
Raw 264.7 Cells ◽  
Dependent Manner ◽  
Red Ginseng ◽  
Health Food ◽  
Griess Reagent ◽  
Korean Red Ginseng ◽  
Concentration Dependent Manner ◽  
Tnf Α

Background and Objectives: Korean red ginseng (KRG) is known as an immune-enhancing health food and has been approved by the Korea Food and Drug Administration. We analyzed the immune-enhancing activity of KRG and its polysaccharide (KRG-P) using RAW264.7 murine macrophage cells. Materials and Methods: The protein and mRNA expression levels of IL-6 and TNF-α were measured using ELISA and qRT-PCR, respectively. Nitric oxide levels were measured using the Griess reagent. The phosphorylation and total protein levels of ERK, p38, JNK, p65, and GAPDH were determined by immunoblot assay. Results: The polysaccharide (KRG-P), but not KRG, produced nitric oxide, interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) in RAW 264.7 cells. KRG-P increased nitric oxide synthase 2 (NOS2), IL-6, and TNF-α expression in RAW264.7 cells. KRG-P also increased phosphorylation of MAPKs (mitogen-activate protein kinases) including ERK, p38, JNK, and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) in a concentration-dependent manner in RAW264.7 cells. Conclusions: The polysaccharide KRG-P is the active component responsible for the immune-enhancing activity of Korean red ginseng and may modulate the systemic immune system in vivo.

Specific activity of Korean red ginseng saponin and non-saponin fractions in ageing-induced rat testicular dysfunction

2017 ◽  
Vol 29 ◽  
pp. 226-237 ◽  
Author(s):  
Spandana Rajendra Kopalli ◽  
Kyu-Min Cha ◽  
Ji-Hoon Ryu ◽  
Seock-Yeon Hwang ◽  
Si-Kwan Kim
Keyword(s):  
Specific Activity ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Saponin ◽  
Testicular Dysfunction

scholarly journals Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries

Foods ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 526
Author(s):  
Sungwoo Chei ◽  
Hyun-Ji Oh ◽  
Hoon Jang ◽  
Kippeum Lee ◽  
Heegu Jin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Nlrp3 Inflammasome ◽  
Ovarian Function ◽  
Oxidative Stress Response ◽  
Stress Factors ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Age Related ◽  
Saponin Fraction

Female infertility and subfertility have been increasing in prevalence worldwide. One contributing factor is ovarian function, which is highly age-dependent. Korean red ginseng is widely used as an herbal medicine and has many beneficial properties. We aimed to determine the effect of the Korean red ginseng saponin fraction (KRGSF) on ovarian function in female C57BL/6 mice. Ovaries were isolated from 6- and 12-month-old female mice and treated with KRGSF, and then RNA was extracted and microarray analysis was performed. The expression of key genes was subsequently verified using quantitative RT-PCR. Aging markedly increased the expression of genes encoding oxidative stress factors and NLRP3 inflammasome components, but the expression of these genes was significantly reduced by KRGSF treatment. Thus, the reduction in ovarian health with age is associated with greater oxidative stress response and inflammation, but KRGSF treatment may limit these age-related changes.

scholarly journals The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation

2015 ◽  
Vol 39 (3) ◽  
pp. 279-285 ◽  
Author(s):  
Bo Ra Jeon ◽  
Su Jung Kim ◽  
Seung Bok Hong ◽  
Hwa-Jin Park ◽  
Jae Youl Cho ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Inhibitory Mechanism ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Crude Saponin ◽  
Saponin Fraction

scholarly journals The effects of red ginseng saponin fraction-A (RGSF-A) on phagocytosis and intracellular signaling in Brucella abortus infected RAW 264.7 cells

2015 ◽  
Vol 362 (11) ◽  
Author(s):  
Lauren Togonon Arayan ◽  
Hannah Leah Simborio ◽  
Alisha Wehdnesday Bernardo Reyes ◽  
Huynh Tan Hop ◽  
WonGi Min ◽  
...  
Keyword(s):  
Brucella Abortus ◽  
Intracellular Signaling ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Red Ginseng ◽  
Ginseng Saponin ◽  
Saponin Fraction
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