Specific activity of Korean red ginseng saponin and non-saponin fractions in ageing-induced rat testicular dysfunction

2017 ◽  
Vol 29 ◽  
pp. 226-237 ◽  
Author(s):  
Spandana Rajendra Kopalli ◽  
Kyu-Min Cha ◽  
Ji-Hoon Ryu ◽  
Seock-Yeon Hwang ◽  
Si-Kwan Kim
Keyword(s):  
Specific Activity ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Saponin ◽  
Testicular Dysfunction

Korean red ginseng attenuates doxorubicin-induced testicular dysfunction in rats by modulating inflammatory, oxidative, and autophagy responses

2018 ◽  
Vol 40 ◽  
pp. 736-743 ◽  
Author(s):  
Kyu-Min Cha ◽  
Spandana Rajendra Kopalli ◽  
Sang Yun Han ◽  
Sang-Ho Lee ◽  
Min-Sik Jeong ◽  
...  
Keyword(s):  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Testicular Dysfunction

scholarly journals Red Ginseng Saponin Fraction A Isolated from Korean Red Ginseng by Ultrafiltration on the Porcine Coronary Artery

2011 ◽  
Vol 35 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Young-Hyun Jung ◽  
Kwang-Yeol Park ◽  
Jin-Hong Jeon ◽  
Yi-Seong Kwak ◽  
Yong-Bum Song ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Porcine Coronary Artery ◽  
Ginseng Saponin ◽  
Saponin Fraction

scholarly journals Korean Red Ginseng Saponin Fraction Rich in Ginsenoside-Rb1, Rc and Rb2 Attenuates the Severity of Mouse Collagen-Induced Arthritis

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Mehari Endale ◽  
Eun Ju Im ◽  
Joo Young Lee ◽  
Sung Dae Kim ◽  
Taddesse Yayeh ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Combined Therapy ◽  
Cartilage Damage ◽  
Serum Antibody ◽  
Ginsenoside Rb1 ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Saponin ◽  
Anti Inflammatory ◽  
Saponin Fraction

Despite a multitude of reports on anti-inflammatory properties of ginseng extracts or individual ginsenosides, data on antiarthritic effect of ginseng saponin preparation with mixed ginsenosides is limited. On the other hand, a combined therapy of safe and inexpensive plant-derived natural products such as ginsenosides can be considered as an alternative to treat arthritis. Our previousin vitrodata displayed a strong anti-inflammatory action of red ginseng saponin fraction-A (RGSF-A). We, herein, report a marked antiarthritic property of RGSF-A rich in ginsenoside Rb1, Rc, and Rb2. Collagen-induced arthritic (CIA) mice were treated with RGSF-A or methotrexate (MTX) for 5 weeks. Joint pathology, serum antibody production and leukocye activation, cytokine production in the circulation, lymph nodes, and joints were examined. RGSF-A markedly reduced severity of arthritis, cellular infiltration, and cartilage damage. It suppressed CD3+/CD69+, CD4+/CD25+, CD8+T-cell, CD19+, B220/CD23+B-cell, MHCII+/CD11c+, and Gr-1+/CD11b+cell activations. It further suppressed anti-CII- or anti-RF-IgG/IgM, TNF-α, IL-1β, IL-17, and IL-6 secretions but stimulated IL-10 levels in the serum, joint, or splenocyte. RGSF-A attenuated arthritis severity, modified leukocyte activations, and restored cytokine imbalances, suggesting that it can be considered as an antiarthritic agent with the capacity to ameliorate the immune and inflammatory responses in CIA mice.

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