scholarly journals CONFIGURATION AND COMPETITIVE REACTIVITY OF LIGANDS IN MIXED LIGAND COMPLEXES OF DIALKYLDITIOPHOSPHATES AND AMINOBENBENZIMIDAZOLE (Part 2. Zn, Fe, Ni)

2020 ◽  
Vol 2020 (3) ◽  
pp. 12-19
Keyword(s):  
Coordination Compounds ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Chelating Ligands ◽  
Frontier Orbitals ◽  
Chemical Methods ◽  
Geometrical Structures ◽  
Software Packages ◽  
Quantum Chemical Methods

With the aim of determination of electronic and geometrical structures of mixed-ligand complexes, theoretical modeling of the structures of coordination compounds of transition metals with dialkyldithiophosphate chelating ligands with aminobenzimidazoles carried out using quantum chemical methods. Using BIOVIA Materials Accelrys Studio 2017 software packages, the geometry, electron density distribution, and frontier orbitals calculated for the mixed ligand complexes Zn(II), Cu(II), Ni(II), Fe(III), which is necessary for understanding the electronic structure of coordination compounds with chelating ligands.

scholarly journals CONFIGURATION AND COMPETITIVE REACTIVITY OF LIGANDS IN MIXED LIGAND COMPLEXES OF DIALKYLDITIOPHOSPHATES AND AMINOBENBENZIMIDAZOLE (Part I: Au, Pt, Ag) AMINOBENBENZIMIDAZOLE (Part 2. Zn, Fe, Ni)

2020 ◽  
pp. 7-16
Keyword(s):  
Coordination Compounds ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Chelating Ligands ◽  
Frontier Orbitals ◽  
Chemical Methods ◽  
Geometrical Structures ◽  
Software Packages ◽  
Quantum Chemical Methods

With the aim of determination of electronic and geometrical structures of mixed-ligand complexes, theoretical modeling of the structures of coordination compounds of transition metals with dialkyldithiophosphate chelating ligands with aminobenzimidazoles carried out using quantum chemical methods. Using BIOVIA Materials Accelrys Studio 2017 software packages, the geometry, electron density distribution, and frontier orbitals calculated for the mixed ligand complexes of Au(III), Pt(II), Ag(I), Cu(II), Ni(II), Fe(III), which are necessary for understanding the electronic structure of coordination compounds with chelating ligands.

scholarly journals Spectral and Biological Studies on New Mixed Ligand Complexes

2018 ◽  
Vol 10 (3) ◽  
pp. 291-302
Author(s):  
T. K. Pal ◽  
M. A. Alam ◽  
J. Hossen ◽  
S. Paul ◽  
H. Ahmad ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Diffusion Method ◽  
Molecular Formula ◽  
Geometrical Structures ◽  
Standard Drug ◽  
Agar Disc ◽  
Biological Studies ◽  
Dithiophosphinic Acid

In this study, new mixed ligand complexes have been prepared from bis(2,4,4-trimethylpentyl)dithiophosphinic acid (C16H35PS2) and 2,9-dimethyl-1,10-phenanthroline (C14H12N2) with various metal(II) ions. The molecular formula of the metal complexes were [Mn(C16H34PS2)(C14H12N2)]Cl (1), [Fe(C16H34PS2)(C14H12N2)]Cl (2), [Co(C16H34PS2) (C14H12N2)]Cl (3), [Zn(C16H34PS2)(C14H12N2)]Cl (4) and [Cd(C16H34PS2)(C14H12N2)]Cl (5). These complexes have been characterized by various physico-chemical techniques such as melting point, molar conductance, magnetic susceptibility measurements as well as UV-Vis, IR, TG and mass spectroscopic analyses. The surface morphology was determined by scanning electron microscope (SEM). The magnetic moment value, color as well as spectral measurements suggested that the geometrical structures of the metal complexes were tetrahedral. The spectral data showed that bis(2,4,4-trimethylpentyl)dithiophosphinic acid and 2,9-dimethyl-1,10-phenanthroline ligands  acted as uninegative and neutral bidentate ligand, respectively. The obtained mixed ligand complexes were more stable in air and highly soluble in common organic solvent. The bio-efficacy of ligands and metal complexes have been screened against the test microorganism using agar disc diffusion method. The complex 4 showed potential antibacterial activity against Sterptococcus aureus as compared to standard drug, imipenem. On the other hand, the complex 3 also displayed more potent antifungal activity against Lecanicillium fungicola. Moreover, the complex 3 was also found to have better scavenging activity against 2,2-diphenyl-1-picrylhydrazyl.

scholarly journals Synthesis Characterization and Biological Activities of Coordination Compounds of 4-Hydroxy-3-nitro-2H-chromen-2-one and Its Aminoethanoic Acid and Pyrrolidine-2-carboxylic Acid Mixed Ligand Complexes

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Temitayo Aiyelabola ◽  
Ezekiel Akinkunmi ◽  
Efere Obuotor ◽  
Idowu Olawuni ◽  
David Isabirye ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Coordination Compounds ◽  
Biological Activities ◽  
Amino Nitrogen ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Molar Ratio ◽  
Cytotoxic Activities ◽  
Carboxylate Oxygen ◽  
Edx Analyses

Coordination compounds of 4-hydroxy-3-nitro-2H-chromen-2-one and their mixed ligand complexes with aminoethanoic acid and pyrrolidine-2-carboxylic acid were synthesized by the reaction of Cu(II) and Zn(II) salts in molar ratio 1 : 2 for the coumarin complexes and 1 : 1 : 1 for the mixed ligand complexes, in basic media. The compounds formed were characterized using infrared, Uv-vis spectrophotometric analyses, mass spectrometry, magnetic susceptibility measurements, and EDX analyses. It was concluded that 4-hydroxy-3-nitro-2H-chromen-2-one coordinated as a monobasic ligand for all the complexes; it also coordinated via the carbonyl moiety in the case of the Cu(II) mixed ligand complexes. Similarly it was proposed that the amino acids also coordinated in a bidentate fashion via their amino nitrogen and carboxylate oxygen atoms. The synthesized compounds were screened for their antimicrobial and cytotoxic activities. The complexes exhibited marginal antimicrobial activity but good cytotoxic activity.

scholarly journals Syntheses, Characterization and Biological Activity of Coordination Compounds of Propanedioic Acid and its Mixed Ligand Complexes with N,N'-Dihydroxy-2,3-butanediimine

2021 ◽  
Vol 33 (8) ◽  
pp. 1911-1918
Author(s):  
T.O. Aiyelabola ◽  
E.O. Akinkunmi ◽  
O Osungunna
Keyword(s):  
Antimicrobial Activity ◽  
Metal Ions ◽  
Coordination Compounds ◽  
Mixed Ligand Complex ◽  
Octahedral Geometry ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Planar Geometry ◽  
Acid Complex ◽  
Square Planar

The coordination compounds of propanedioic acid with cobalt(II), nickel(II) and copper(II) ions were synthesized using metal:ligand 1:2. In addition to this, mixed ligand complexes using the same metal ions with propanedioic acid as the primary ligand and N,N'-dihydroxy-2,3-butanediimine as the secondary ligand were also synthesized using M:L1:L2 (1:1:1) where L1 = propanedioic acid, L2 = N,N'-dihydroxy-2,3-butanediimine and M = Cu(II), Ni(II) and Cu(II). The synthesized compounds were characterized using FTIR, UV-vis, magnetic susceptibility measurement and percentage metal composition. The ligand and its metal complexes were tested for their cytotoxic and antibacterial activities. Results indicated that a dimeric square planar geometry was assumed by the cobalt(II) and nickel(II) propanedioic acid complexes. Octahedral geometry was proposed for both cobalt(II) and copper(II) mixed ligand complexes. A dinuclear square pyramidal geometry was suggested for the copper(II) propanedioic acid complex and square planar/octahedral geometry for the nickel(II) mixed ligand complex. The copper(II) propanedioic acid complex elicited the best cytotoxic activity. On the other hand, the nickel(II) propanedioic acid complex showed the remarkable antimicrobial activity. The compounds exhibited good antimicrobial activity in most of the cases with the exception of the cobalt(II) propanedioic acid complex. It was concluded that coordination of the ligands to the metal ions lowered the toxicity of the ligands. It was further concluded that the antimicrobial activity of the compounds was partly dependent on the synergism/additive effect of the intrinsic therapeutic properties of the metal ion and the ligands within the coordination sphere of the complexes synthesized. And this is also in part a function of the geometry assumed by the complexes.

scholarly journals Syntheses of Coordination Compounds of 2-Amino-3-Methylbutanoic Acid Their Mixed Ligand Complexes and Antibacterial Activities

2020 ◽  
Vol 10 (03) ◽  
pp. 67-85
Author(s):  
Temitayo O. Aiyelabola ◽  
Iyanuoluwa E. Okunade ◽  
Johan H. L. Jordaan ◽  
Daniel P. Otto
Keyword(s):  
Coordination Compounds ◽  
Antibacterial Activities ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes
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