scholarly journals Statistical models for biphasic dose-response relationships (hormesis) in toxicological studies

2017 ◽  
Vol 12 (1) ◽  
pp. 39-55 ◽  
Author(s):  
C.O. Nweke ◽  
C.J. Ogbonna
Keyword(s):  
Dose Response ◽  
Statistical Models ◽  
Toxicological Studies ◽  
Biphasic Dose Response

Comparing two statistical models for low boom dose-response relationships with correlated responses

2021 ◽  
Vol 150 (4) ◽  
pp. A260-A260
Author(s):  
Aaron B. Vaughn ◽  
William Doebler ◽  
Kathryn Ballard ◽  
Jonathan Rathsam
Keyword(s):  
Dose Response ◽  
Statistical Models ◽  
Correlated Responses

Biphasic Dose/Response of Photobiomodulation Therapy on Culture of Human Fibroblasts

2020 ◽  
Vol 38 (7) ◽  
pp. 413-418
Author(s):  
Genoveva Lourdes Flores Luna ◽  
Ana Laura Martins de Andrade ◽  
Patricia Brassolatti ◽  
Paulo Sérgio Bossini ◽  
Fernanda de Freitas Anibal ◽  
...  
Keyword(s):  
Dose Response ◽  
Human Fibroblasts ◽  
Photobiomodulation Therapy ◽  
Biphasic Dose Response

scholarly journals Defining Hormesis: Evaluation of a Complex Concentration Response Phenomenon

2010 ◽  
Vol 29 (3) ◽  
pp. 235-246 ◽  
Author(s):  
Eric L. Kendig ◽  
Hoa H. Le ◽  
Scott M. Belcher
Keyword(s):  
Dose Response ◽  
Ad Hoc ◽  
Scientific Evidence ◽  
Biological Molecules ◽  
Response Theory ◽  
Inappropriate Use ◽  
Toxicological Studies ◽  
History Of ◽  
High Doses ◽  
Dose Responses

Hormesis describes dose-response relationships characterized by a reversal of response between low and high doses of chemicals, biological molecules, physical stressors, or other initiators of a response. Acceptance of hormesis as a viable dose-response theory has been limited until recently, in part, because of poor conceptual understanding, ad hoc and inappropriate use, and lack of a defined mechanism. By examining the history of this dose-response theory, it is clear that both pharmacological and toxicological studies provide evidence for hormetic dose responses, but retrospective examination of studies can be problematic at best. Limited scientific evidence and lack of a common lexicon with which to describe these responses have left hormesis open to inappropriate application to unrelated dose-response relationships. Future studies should examine low-dose effects using unbiased, descriptive criteria to further the scientific understanding of this dose response. A clear, concise definition is required to further the limited scientific evidence for hormetic dose responses.

Biphasic Dose–Response Phenomenon Induced by Xenobiotics and Its Application in Soil Risk Assessment

2017 ◽  
pp. 125-138
Author(s):  
Muhammad Zaffar Hashmi ◽  
Adeel Mehmood ◽  
Sohaib Khan ◽  
Ahmad Hasnain ◽  
Zulkifl Ahmed
Keyword(s):  
Risk Assessment ◽  
Dose Response ◽  
Soil Risk Assessment ◽  
Biphasic Dose Response

Effects of in vivo cholinergic stimulation of rat exocrine pancreas

1983 ◽  
Vol 244 (6) ◽  
pp. G623-G629
Author(s):  
G. Adler ◽  
G. Gerhards ◽  
J. Schick ◽  
G. Rohr ◽  
H. F. Kern
Keyword(s):  
Dose Response ◽  
Exocrine Pancreas ◽  
Pancreatic Enzyme ◽  
Target Cells ◽  
Response Curves ◽  
Cholinergic Agent ◽  
Rat Exocrine Pancreas ◽  
Biphasic Dose Response

Peptide and cholinergic secretagogues both produce biphasic dose-response curves for pancreatic enzyme secretion in vitro: supraoptimal doses result in submaximal secretory responses. We compared the effects of maximal and supramaximal doses of a cholinergic agent (carbachol) on rat exocrine pancreas in vivo. In conscious rats, volume and enzyme output were measured from the cannulated pancreatic duct during infusion of carbachol for 3 h. Infusion of 5 X 10(-7) mol . kg-1 . h-1 carbachol caused optimal stimulation, whereas a supraoptimal dose (5 X 10(-6) mol . kg-1 . h-1) resulted in submaximal response. Similar results were achieved when discharge of amylase and protein synthesis was determined in vitro after carbachol in vivo. Supraoptimal doses of carbachol increased serum amylase and enhanced acinar cell lysosomal activity in the Golgi area. The latter appeared to induce fusion of zymogen granules, which resulted in cytoplasmic vacuoles. The in vivo results corroborate in vitro findings of a biphasic dose-response relationship for carbachol and demonstrate destructive effects of supraoptimal concentrations on target cells.

The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells

2009 ◽  
Vol 23 (4) ◽  
pp. 660-666 ◽  
Author(s):  
Changfu Hao ◽  
Weidong Hao ◽  
Xuetao Wei ◽  
Lina Xing ◽  
Jianjun Jiang ◽  
...  
Keyword(s):  
Dose Response ◽  
Hek293 Cells ◽  
Biphasic Dose Response
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