Effects of aerobic exercise induced oxidative stress on energy regulatory hormones of irisin and nesfatin-1 in healthy females

2021 ◽  
pp. 5-8
Keyword(s):  
Oxidative Stress ◽  
Aerobic Exercise ◽  
Muscle Activity ◽  
Venous Blood ◽  
Work Intensity ◽  
Blood Samples ◽  
Oxidative Stress Parameters ◽  
Exercise Induced ◽  
Energy Regulatory ◽  
Healthy Females

Objectives: Exercise is an important tool to stimulate oxidative stress and metabolic demands. We intended to evaluate impact of aerobic exercise on oxidative stress parameters and their relationships between irisin and nesfatin-1 levels. Material and Method: Total of ten healthy sedentary female subjects exercise for a 30 min of aerobic running exercise work intensity corresponded to associated their anaerobic threshold. Venous blood samples were taken before and at the end of the exercise. Serum irisin nesfatin-1 and TAS and TOS levels were analyzed using ELISA methods. Results: Exercise caused increase of irisin (11%) and nesfatin-1 (12%) levels. During exercise a decrease in TAS (-11%) and increased in TOS (29%) levels were observed. There was a significant correlation between changes of irisin and TAS levels (R=-0.67594, p=0.03). Conclusion: Consequently, exercise induced skeletal muscle activity may cause increase in oxidative stress, irisin and nesfatin-1 levels. Irisin hormone may be a secreted against to increased exercise-induced increased oxidative stress muscle activity.

scholarly journals Expression of oxidative stress in metastatic retinoblastomaa comparative study

2012 ◽  
Vol 4 (2) ◽  
pp. 271-276 ◽  
Author(s):  
S Mukhopadhyay ◽  
J Dutta ◽  
R Raut ◽  
H Datta ◽  
A K Bhattacharyay
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Distant Metastasis ◽  
Venous Blood ◽  
Oxygen Species ◽  
Blood Samples ◽  
Number Of Patients ◽  
Intraocular Retinoblastoma

Objective: To compare oxidative stress between primary retinoblastoma and retinoblastoma with distant metastasis. Patients and methods: Forty consecutive patients presented with primary retinoblastoma and the same number of patients presented with distant metastasis, attending the outpatient department of our hospital between August 2002 and April 2005. All the patients with retinoblastoma underwent a standard metastasis workup and were subsequently categorized into two groups (without metastasis and with metastasis).Venous blood samples were drawn from each patient. After proper centrifugation, serum was collected and antioxidant enzymes and reactive oxygen species (ROS) were assayed. Main outcome measures: Serum collected from the patients was subjected to biochemical assay of the antioxidant enzymes (superoxide dismutase, catalase and peroxidise) and ROS to determine any difference in enzyme activity between the two groups. Results: Antioxidant levels were found to be less in the metastasis group as compared to the primary intraocular retinoblastoma group(p<0.05).Mean ROS activity was found to be increased in metastatic group (p<0.05). Conclusion: The decreased antioxidant enzymes level along with increased ROS activity in patients with metastatic retinoblastoma reflect increased oxidative stress as compared to primary intraocular retinoblastoma patients.DOI: http://dx.doi.org/10.3126/nepjoph.v4i2.6543 Nepal J Ophthalmol 2012; 4 (2): 271-276  

scholarly journals Statins Attenuate the Increase in P-Selectin Produced by Prolonged Exercise

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Amanda Zaleski ◽  
Jeffrey Capizzi ◽  
Kevin D. Ballard ◽  
Christopher Troyanos ◽  
Aaron Baggish ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Inflammatory Response ◽  
Inflammatory Markers ◽  
Prolonged Exercise ◽  
Venous Blood ◽  
Serum Levels ◽  
Blood Samples ◽  
Boston Marathon ◽  
Exercise Induced ◽  
Response To Exercise

Strenuous endurance exercise increases inflammatory markers and acutely increases cardiovascular risk; however, statins may mitigate this response. We measured serum levels of p-selectin in 37 runners treated with statins and in 43 nonstatin treated controls running the 2011 Boston Marathon. Venous blood samples were obtained the day before (PRE) as well as within 1 hour after (FINISH) and 24 hours after (POST) the race. The increase in p-selectin immediately after exercise was lower in statin users (PRE to FINISH: 20.5 ± 19.4 ng/mL) than controls (PRE to FINISH: 30.9 ± 27.1 ng/mL;P<0.001). The increase in p-selectin 24 hours after exercise was also lower in statin users (PRE to POST: 21.5 ± 26.6 ng/mL) than controls (PRE to POST: 29.3 ± 31.9 ng/mL;P<0.001). Furthermore, LDL-C was positively correlated with p-selectin at FINISH and POST (P<0.01andP<0.05, resp.), irrespective of drug treatment, suggesting that lower levels of LDL-C are associated with a reduced inflammatory response to exercise. We conclude that statins blunt the exercise-induced increase in p-selectin following a marathon and that the inflammatory response to a marathon varies directly with LDL-C levels.

scholarly journals Thyroid hormone responses to acute aerobic exercise

2021 ◽  
Vol 25 (6) ◽  
pp. 359-363
Author(s):  
Mustafa Ş. Akgül ◽  
Bilgehan Baydil
Keyword(s):  
Thyroid Hormone ◽  
Aerobic Exercise ◽  
Venous Blood ◽  
P Value ◽  
Free T4 ◽  
Blood Samples ◽  
The Social ◽  
Significant Difference ◽  
Hormone Responses ◽  
Shuttle Run

Background and Study Aim. Thyroid hormone responses to acute maximal aerobic exercise is still unclear, so the aim of the study is to investigate the effect of acute maximal aerobic exercise resulting in fatigue on blood thyroid levels in men and women. Material and Methods. The study included 8 male and 7 female subjects who did not actively exercise. Both group participants were students in the Kastamonu University in the period of study. The heights, weights, resting hearth rates and 5 cc. venous blood samples of subjects were taken before the exercise. The subjects warmed up for ten minutes before they had 20 m shuttle run. The purpose of this test was to tire the subjects to the exhaustion. The heart rate were measured at the end of the test in order to determine the exhaustion levels of the participants. The 5 cc. venous blood samples were taken again just after the exhaustion exercise. Statistical analysis was carried out using Statistical Package for the Social Sciences (SPSS) 23 program (SPSS Inc. Chicago. II. USA). P value was set at p<0.05. Results. When results were compared between both sexes, no significant difference was found among variables (p>0.05). There was significant change in TSH values in all group. They increased following the exercise compared to pre-exercise values. Moreover, total T3 decreased in all group. No other significant difference was found in free T3 and free T4 variables. Conclusions. In conclusion, thyroid responses to exercise emerge in a very complex way, which makes it difficult to reach a clear conclusion about its effects. The reason why the results are so contradictory is that the duration and intensity of the exercise, age, not being able to control the diet, and the timing of collection of blood samples after exercise.

Acute responses of hemodynamic and oxidative stress parameters to aerobic exercise with blood flow restriction in hypertensive elderly women

2018 ◽  
Vol 45 (5) ◽  
pp. 1099-1109 ◽  
Author(s):  
Angélica Barili ◽  
Vanessa da Silva Corralo ◽  
Andréia Machado Cardoso ◽  
Aline Mânica ◽  
Beatriz da Silva Rosa Bonadiman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Flow ◽  
Aerobic Exercise ◽  
Elderly Women ◽  
Blood Flow Restriction ◽  
Flow Restriction ◽  
Oxidative Stress Parameters ◽  
Acute Responses ◽  
And Oxidative Stress ◽  
Stress Parameters

Sampling Time is Crucial for Measurement of Aerobic Exercise-Induced Oxidative Stress

2007 ◽  
Vol 39 (7) ◽  
pp. 1107-1113 ◽  
Author(s):  
YIANNIS MICHAILIDIS ◽  
ATHANASIOS Z. JAMURTAS ◽  
MICHALIS G. NIKOLAIDIS ◽  
IOANNIS G. FATOUROS ◽  
YIANNIS KOUTEDAKIS ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aerobic Exercise ◽  
Sampling Time ◽  
Exercise Induced

Changes in interstitial K+ and pH during exercise: implications for blood flow regulation

2007 ◽  
Vol 32 (5) ◽  
pp. 846-851 ◽  
Author(s):  
Carsten Juel
Keyword(s):  
Blood Flow ◽  
Muscle Activity ◽  
Sensory Nerve ◽  
Ion Composition ◽  
Intense Exercise ◽  
Blood Samples ◽  
Vasodilatory Effect ◽  
Blood Ph ◽  
T Tubules ◽  
Exercise Induced

The analysis of blood samples has clearly demonstrated that exercise is associated with the release of K+ and H+ from muscle. However, blood samples give only incomplete information about the ion changes in the muscle interstitium. Interstitial changes in ion composition may affect the transport properties of the sarcolemmal membrane, may affect fibre excitability and induce fatigue, and may affect sensory nerve endings. Therefore, to better understand muscle function, it is important to quantify the exercise-induced interstitial ion changes. Both interstitial K+ and H+ changes have been quantified with the microdialysis technique. Interstitial K+ accumulation is dependent on the intensity and duration of muscle activity and may reach 10 mmol/L during intense exercise, and the concentration in T-tubules may be even higher. Thus, interstitial K+ can reach a level that affects fibre excitability and the development of fatigue. It has also been demonstrated with microdialysis that the interstitial decrease in pH during muscle activity is larger than the reduction in blood pH. Ion changes in the interstitium may affect blood flow directly or indirectly. Infusion of K+ into the femoral artery in humans has demonstrated that blood flow is affected by changes in K+ as low as 0.1 mmol/L. The vasodilatory effect of K+ can be inhibited with simultaneous barium infusion, indicating that inward rectifier potassium (Kir)channels are involved. Acidosis has a direct effect on blood flow and an indirect effect, mediated by changes in other vasoactive compounds.

A Prior High-Intensity Exercise Bout Attenuates the Vascular Dysfunction Resulting From a Prolonged Sedentary Bout

2019 ◽  
Vol 16 (10) ◽  
pp. 916-924
Author(s):  
Ryan S. Garten ◽  
Matthew C. Scott ◽  
Tiffany M. Zúñiga ◽  
Austin C. Hogwood ◽  
R. Carson Fralin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aerobic Exercise ◽  
Lower Limb ◽  
High Intensity ◽  
Vascular Function ◽  
Vascular Dysfunction ◽  
Blood Samples ◽  
Prolonged Sitting ◽  
Leg Movement ◽  
High Intensity Interval

Background: This study sought to determine the impact of an acute prior bout of high-intensity interval aerobic exercise on attenuating the vascular dysfunction associated with a prolonged sedentary bout. Methods: Ten young (24 ± 1 y) healthy males completed two 3-hour sessions of prolonged sitting with (SIT-EX) and without (SIT) a high-intensity interval aerobic exercise session performed immediately prior. Prior to and 3 hours into the sitting bout, leg vascular function was assessed with the passive leg movement technique, and blood samples were obtained from the lower limb to evaluate changes in oxidative stress (malondialdehyde and superoxide dismutase) and inflammation (interleukin-6). Results: No presitting differences in leg vascular function (assessed via passive leg movement technique-induced hyperemia) were revealed between conditions. After 3 hours of prolonged sitting, leg vascular function was significantly reduced in the SIT condition, but unchanged in the SIT-EX. Lower limb blood samples revealed no alterations in oxidative stress, antioxidant capacity, or inflammation in either condition. Conclusions: This study revealed that lower limb vascular dysfunction was significantly attenuated by an acute presitting bout of high-intensity interval aerobic exercise. Further analysis of lower limb blood samples revealed no changes in circulating oxidative stress or inflammation in either condition.

scholarly journals ERYTHROCYTE OXIDATIVE STATUS AFTER MAXIMAL AEROBIC TEST IN WRESTLERS

2019 ◽  
Vol 19 (1) ◽  
pp. 15-21
Author(s):  
A Alexandrova ◽  
L Petrov ◽  
R Makaveev ◽  
E Tsvetanova ◽  
A Georgieva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Venous Blood ◽  
Hemoglobin Concentration ◽  
Oxidative Status ◽  
Total Glutathione ◽  
Sod Activity ◽  
Blood Samples

Aim. The aim of this study was to determine the changes in the erythrocyte oxidative status of the wrestlers after performing the maximal aerobic test, by registering in erythrocytes the levels of lipid peroxidation (LPO), total glutathione (tGSH) and activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Materials and methods. A group of 12 healthy wrestlers conducted a treadmill maximal aerobic test, and venous blood samples were obtained before and immediately after the exercise. Erythrocytes were separated from plasma and used for spectrophotometric determination of LPO, tGSH and enzyme activities. Plasma was used for determination of hemoglobin concentration (Hb) as an index of hemolysis. Results. The performance of the maximal aerobic test resulted in a significant increase of Hb in blood plasma, a decrease of LPO, and no changes of the tGSH level in erythrocytes. In regards to antioxidant enzymes, our results showed an increase in the activity of GPx, while the CAT and SOD activity remain unchanged. Conclusions. It can be concluded that in active athletes, predominate erythrocytes that are more resistant to oxidative stress, because of the accelerated hemolysis induced by physical exercise, lead to the elimination of the old and oxidative modified cells.

scholarly journals The effects of grape seed extract supplementation on exercise-induced oxidative stress in young untrained males

2022 ◽  
Author(s):  
Hamid Reza Zolfi ◽  
Vahid Sari-Sarraf ◽  
Hossein Babaei ◽  
Amirmansour Vatankhah
Keyword(s):  
Oxidative Stress ◽  
Aerobic Exercise ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Controlled Study ◽  
Total Antioxidant ◽  
Exercise Induced

Background and Purpose: The aim of this study was to determine the effect of acute aerobic exercise and 14-days grape seed extract supplementation on total antioxidant capacity, lipid peroxidation and muscle cell damage biomarkers in untrained males Materials and Methods: In a randomized, double-blinded, and placebo-controlled study, twenty-two male students (age 19±1 years, weight 67.44±7 kg, BMI 22±2, V̇ O2max 39±2 ml/kg-1 /min-1 ) were randomly assigned to two groups of grape seed extract and placebo (PLA) (GSE: 200 mg/day for two weeks). After subsequent 14-days of supplementation, subjects did a single session of aerobic exercise (running) on treadmill at 75% VO2max for 30 minutes. Blood samples were taken 3 times: prior to supplementation (baseline), 14-days after supplementation, and immediately after exercise (post-exercise). Total antioxidant capacity (TAC), malondialdehyde (MDA), creatine kinase (CK), lactate dehydrogenase (LDH) and lactate were measured. TAC was determined by ABTs method. The collected data were then analyzed by running analysis of variance (ANOVA) with repeated measure and Bonferroni post-hoc tests as appropriate using SPSS17 at p<0.05. Results: Malondialdehyde, CK, LDH, Lactate were significantly increased after aerobic exercise (p<0.05). Short-term GSE supplementation significantly prevented MDA and CK cascade after exercise compared to PLA (p<0.05) but, it had no significant effect on basal parameters (p>0.05). The exercise had also no significant effect on total antioxidant capacity in any of the groups (p>0.05). Conclusion: Aerobic exercise could increase blood oxidative stress biomarkers and GSE supplementation, due to influential antioxidant effect; yet, it could attenuate exercise-induced oxidative stress in men

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