scholarly journals Water-Filling: A Novel Approach of Load Rebalancing for File Systems in Cloud

2015 ◽  
Vol 126 (14) ◽  
pp. 28-33
Author(s):  
Divya Diwakar ◽  
Sushil Chaturvedi ◽  
S.K. Shrivastava
Keyword(s):  
File Systems ◽  
Novel Approach ◽  
Water Filling

Real-Time, Interposable Communication for Web Services

2015 ◽  
Vol 2 (5) ◽  
pp. 40
Author(s):  
Sasi Palarivattom ◽  
Kayamkulam Kochunni
Keyword(s):  
Web Services ◽  
Real Time ◽  
Operating Systems ◽  
File Systems ◽  
Evolutionary Programming ◽  
Position Paper ◽  
Hash Tables ◽  
Novel Approach ◽  
To Come ◽  
Future Work

In recent years, much research has been devoted to the evaluation of checksums; nevertheless, few have simulated the construction of RPCs. In this position paper, we prove the development of robots. We motivate a novel approach for the improvement of hash tables (Intwist), which we use to prove that evolutionary programming can be made wireless, cacheable, and semantic. In conclusion, our experiences with in twist and real-time archetypes show that the Turing machine and journaling file systems can interfere to overcome this quagmire. We considered how gigabit switches can be applied to the construction of operating systems. in twist has set a precedent for signed algorithms, and we expect that leading analysts will explore our system for years to come. One potentially profound shortcoming of in twist is that it might allow Internet QoS; we plan to address this in future work.

scholarly journals An approach to enhance pnetCDF performance in environmental modeling applications

2014 ◽  
Vol 7 (6) ◽  
pp. 7427-7459
Author(s):  
D. C. Wong ◽  
C. E. Yang ◽  
J. S. Fu ◽  
K. Wong ◽  
Y. Gao
Keyword(s):  
Data Aggregation ◽  
File Systems ◽  
Large Data ◽  
Environmental Modeling ◽  
Small Scale ◽  
Air Quality Model ◽  
Quality Model ◽  
Novel Approach ◽  
Column Dimension ◽  
Better Than

Abstract. Data intensive simulations are often limited by their I/O performance, and novel techniques need to be developed in order to overcome this limitation. The software package, pnetCDF which works with parallel file systems, was developed to address this issue by providing parallel I/O capability. This study examines the performance of a novel approach which performs data aggregation along either row or column dimension of MPI processes on a spatially decomposed domain, and then applies the pnetCDF parallel I/O paradigm. The test was done with three different domain sizes which represent small, moderately large, and large data domains, using a small-scale Community Multi-scale Air Quality model (CMAQ) mock-up code. The examination includes comparing I/O performance with traditional serial I/O technique, straight application of pnetCDF, and the data aggregation along row and column dimension before applying pnetCDF. After the comparison, "optimal" I/O configurations of this novel approach were quantified. Data aggregation along the row dimension (pnetCDFcr) works better than along the column dimension (pnetCDFcc) although it may perform slightly worse than the straight pnetCDF method with a small number of processors. When the number of processors becomes larger, pnetCDFcr out performs pnetCDF significantly. If the number of processors keeps increasing, pnetCDF reaches a point where the performance is even worse than the serial I/O technique. This new technique has also been tested for a real application where it performs two times better than the straight pnetCDF paradigm.

scholarly journals A Novel Approach for Replica Synchronization in Hadoop Distributed File Systems

2015 ◽  
Vol 50 ◽  
pp. 590-595 ◽  
Author(s):  
Miss. J. Vini ◽  
Rachel Nallathamby ◽  
C.R. Rene Robin
Keyword(s):  
File Systems ◽  
Distributed File Systems ◽  
Novel Approach

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

Abstract #709: E-Consults: A Novel Approach to Increase Access to Subspecialty Care in Endocrinology

2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  
Novel Approach
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