scholarly journals Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats

2012 ◽  
Vol 45 (4) ◽  
pp. 241 ◽  
Author(s):  
Richard N. Ranson ◽  
Jennifer H. Connelly ◽  
Robert M. Santer ◽  
Alan H. D. Watson
Keyword(s):  
Spinal Cord ◽  
Young Adult ◽  
Aged Rats ◽  
Lumbosacral Spinal Cord ◽  
Nuclear Expression

scholarly journals Age-related NADPH-diaphorase positive bodies in the lumbosacral spinal cord of aged rats

2006 ◽  
Vol 69 (5) ◽  
pp. 297-310 ◽  
Author(s):  
Huibing Tan ◽  
Jianwen He ◽  
Songyan Wang ◽  
Kazuho Hirata ◽  
Zhengwei Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Nadph Diaphorase ◽  
Aged Rats ◽  
Lumbosacral Spinal Cord ◽  
Age Related

scholarly journals Rostrocaudal Distribution of the C-Fos-Immunopositive Spinal Network Defined by Muscle Activity during Locomotion

2021 ◽  
Vol 11 (1) ◽  
pp. 69
Author(s):  
Natalia Merkulyeva ◽  
Vsevolod Lyakhovetskii ◽  
Aleksandr Veshchitskii ◽  
Oleg Gorskii ◽  
Pavel Musienko
Keyword(s):  
Spinal Cord ◽  
Locomotor Activity ◽  
Control Systems ◽  
Muscle Activity ◽  
Knee Extensors ◽  
Emg Activity ◽  
Lumbosacral Spinal Cord ◽  
Adductor Muscles ◽  
Spinal Network ◽  
Hip Flexor

The optimization of multisystem neurorehabilitation protocols including electrical spinal cord stimulation and multi-directional tasks training require understanding of underlying circuits mechanisms and distribution of the neuronal network over the spinal cord. In this study we compared the locomotor activity during forward and backward stepping in eighteen adult decerebrated cats. Interneuronal spinal networks responsible for forward and backward stepping were visualized using the C-Fos technique. A bi-modal rostrocaudal distribution of C-Fos-immunopositive neurons over the lumbosacral spinal cord (peaks in the L4/L5 and L6/S1 segments) was revealed. These patterns were compared with motoneuronal pools using Vanderhorst and Holstege scheme; the location of the first peak was correspondent to the motoneurons of the hip flexors and knee extensors, an inter-peak drop was presumably attributed to the motoneurons controlling the adductor muscles. Both were better expressed in cats stepping forward and in parallel, electromyographic (EMG) activity of the hip flexor and knee extensors was higher, while EMG activity of the adductor was lower, during this locomotor mode. On the basis of the present data, which showed greater activity of the adductor muscles and the attributed interneuronal spinal network during backward stepping and according with data about greater demands on postural control systems during backward locomotion, we suppose that the locomotor networks for movements in opposite directions are at least partially different.

Acute Transverse Myelitis Associated with COVID-19 vaccine: A Case Report

2021 ◽  
Vol 12 (3) ◽  
pp. 2083-2087
Author(s):  
Ali Alshararni
Keyword(s):  
Spinal Cord ◽  
Case Report ◽  
Acute Inflammation ◽  
Transverse Myelitis ◽  
Preventive Measure ◽  
Mri Findings ◽  
Dorsal Spinal Cord ◽  
Lumbosacral Spinal Cord ◽  
Acute Transverse Myelitis ◽  
Magnetic Resonance Imaging Mri

The case report demonstrates the issue of Khalid Ali, who is a citizen of Yamen, explicitly living in Saudi Arabia. He is 38 years, weighs 82kgs, and of 162 cm in height. He is a sales professional and married with two kids. Khalid Ali has been living healthy until two years ago when he started experiencing pains in his lower extremities accompanied by numbness. He was treated, and everything went back to normal until soon when the case came back after the administration of the Pfizer vaccine as a preventive measure for COVID-19 disease. The consequence of the administration of the Pfizer vaccine resulted in severe pain and weaknesses in his legs and severe headache on the second day, which resulted in him being put on an ICU after 48 hours since he was almost paralyzed. A series of tests were conducted on him, including magnetic resonance imaging (MRI), hematology, and biochemistry which involved Cerebrospinal Fluid (CSF) protein test. MRI findings were significant since they indicated acute inflammation on the spine observed on the dorsal spinal cord with contrast and lumbosacral spinal cord. All the hematology tests turned out to be expected. Biochemistry conducted tests were similarly standard except for CSF protein which was highly abnormal. The combination of the high abnormal CSF protein test and acute inflammation of the spine observed from the MRI findings were confirmed evidence of acute transverse myelitis as a result of the administration of the Pfizer vaccine.

Does Motor Learning Occur in the Spinal Cord?

1997 ◽  
Vol 3 (5) ◽  
pp. 287-294 ◽  
Author(s):  
V. Reggie Edgerton ◽  
Roland R. Roy ◽  
Ray De Leon Niranjala Tillakaratne ◽  
John A. Hodgson
Keyword(s):  
Spinal Cord ◽  
Motor Task ◽  
Lumbar Spinal Cord ◽  
Lumbosacral Spinal Cord ◽  
Patterns Of Use ◽  
The Neural Network ◽  
The Central Nervous System ◽  
Network Plasticity ◽  
Lumbar Spinal ◽  
The Brain

It is becoming clear that the plasticity of the sensory-motor networks of the adult mammalian lumbosacral spinal cord is much greater than and is more dependent on the specific patterns of use than has been previously assumed. Using a wide variety of experimental paradigms in which the lumbar spinal cord is isolated from the brain, it has been shown that the lumbosacral spinal cord can learn to execute stepping or standing more successfully if that specific task is practiced. It also appears that the sensory input associated with the motor task and/or the manner in which it is interpreted by the spinal cord are important components of the neural network plasticity. Early evidence suggests that several neurotransmitter systems in the spinal cord, to include glycinergic and GABAergic systems, adapt to repetitive use. These studies extend a growing body of evidence suggesting that memory and learning are widely distributed phenomena within the central nervous system. NEUROSCIENTIST 3:287–294, 1997

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