scholarly journals Cytoprotective and antioxidant effects of aged garlic extract against adriamycin-induced cardiotoxicity in adult male rats

2020 ◽  
Vol 53 (2) ◽  
pp. 201-215
Author(s):  
Ashraf Youssef Nasr ◽  
Rasha A. Alshali
Keyword(s):  
Adult Male ◽  
Garlic Extract ◽  
Male Rats ◽  
Aged Garlic Extract ◽  
Antioxidant Effects ◽  
Aged Garlic

Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity

2009 ◽  
Vol 87 (8) ◽  
pp. 633-640 ◽  
Author(s):  
Erkan Demirkaya ◽  
Aslıhan Avci ◽  
Vural Kesik ◽  
Yıldırım Karslioglu ◽  
Emin Oztas ◽  
...  
Keyword(s):  
Grape Seed ◽  
Garlic Extract ◽  
Natural Antioxidant ◽  
Male Rats ◽  
Free Oxygen Radicals ◽  
Protective Effects ◽  
Aged Garlic Extract ◽  
Positive Effects ◽  
Grape Seed Proanthocyanidin ◽  
Aged Garlic

Doxorubicin (DXR) is a chemotherapeutic agent used effectively in the treatment of several childhood malignancies. During treatment, cardiotoxicity caused by cell damage due to the free oxygen radicals that are generated is a major limiting factor. This study was undertaken to determine whether DXR-induced cardiotoxicity could be prevented by natural foods with antioxidant properties such as aged garlic extract (AGEX), grape seed proanthocyanidin (PA), and hazelnut. Wistar albino male rats were assigned randomly to 9 groups each consisting of 15 rats. AGEX, PA, and hazelnut groups received these antioxidants in addition to their standard rat diet. They were also treated with cumulative intraperitoneal (i.p.) injections according to 2 different regimens: either a high-dose of 15 mg/kg DXR (3.75 mg/kg per week for 4 weeks) or a low-dose of 7.5 mg/kg DXR (1.875 mg/kg per week for 4 weeks). The control group received i.p. 0.9% saline. AGEX, PA, or hazelnut supplements were given orally to the groups for a 6-week period starting 1 week before the DXR treatment and ending 1 week after the treatment. One week after the last DXR injection, heart tissue samples were analyzed to determine malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and xanthine oxidase (XO) levels, and serum samples were taken for creatine kinase (CK). There were no significant changes in MDA levels among the control, DXR-treated groups, or supplemented groups that received additional natural antioxidant foods. SOD enzyme levels were decreased in rats treated with DXR. PA prevented the decrease at low doses of DXR. DXR treatment decreased CAT enzyme levels, but additional PA and hazelnut consumption increased these levels at low cumulative doses. XO enzyme levels were decreased in AGEX and hazelnut groups, but PA prevented the decrease. CK levels were elevated after DXR administration, indicating myocardial injury, but PA significantly reversed this. Although there were no differences histopathologically between AGEX, PA, and hazelnut groups, the protective effects of AGEX and PA were evident in electron microscopy. In conclusion, the positive effects of natural antioxidant foods on the prevention of DXR-induced cardiac injury could not be clearly shown on the basis of antioxidant enzymes. However, the electron microscopic changes clearly demonstrated the protective effects of AGEX and PA. The supplementation of these antioxidant foods over longer periods may show more definitive results. Human studies with different doses are needed to evaluate the effects of these foods on the human heart.

scholarly journals The Protective Effect of Aged Garlic Extract on Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Inflammations in Male Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Gehan Moustafa Badr ◽  
Jawaher Abdulaziz AL-Mulhim
Keyword(s):  
Mucosal Healing ◽  
Garlic Extract ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Aged Garlic Extract ◽  
Drug Induced ◽  
Potent Effect ◽  
Anti Inflammatory ◽  
Aged Garlic

Natural products have long gained wide acceptance among the public and scientific community in the gastrointestinal ulcerative field. The present study explore the potential effects of aged garlic extract (AGE) on indomethacin-(IN-) induced gastric inflammation in male rats. Animals were divided into six groups (n=8) control group, IN-induced gastric inflammation group via oral single dose (30 mg/kg to fasted rats) two AGE orally administered groups (100 and 200 mg/kg for 30 consecutive days) two AGE orally administered groups to rats pretreated with IN at the same aforementioned doses. The results declared the more potent effect of the higher AGE dose (200 mg/kg) as compared to that of the 100 mg/kg dose in the gastroprotective effects reflected by significant gastric mucosal healing of damage and reduction in the total microbial induced due to indomethacin administration. In addition to the significant effect to normalize the significant increase in malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor-α(TNF-α) values, and the significant decrease in the total glutathione (tGSH), superoxide dismutase (SOD), and catalase (CAT) values induced by indomethacin. The results support AGE antioxidant, anti-inflammatory, and antimicrobial potency reflected by the healing of the gastric tissue damage induced by indomethacin.

Antioxidant Effects of Tetrahydro-β-carboline Derivatives Identified in Aged Garlic Extract

2003 ◽  
pp. 380-404
Author(s):  
Makoto Ichikawa ◽  
Kenjro Ryu ◽  
Jiro Yoshida ◽  
Nagatoshi Ide ◽  
Susumu Yoshida ◽  
...  
Keyword(s):  
Garlic Extract ◽  
Aged Garlic Extract ◽  
Antioxidant Effects ◽  
Aged Garlic

Antioxidant effects of fructosyl arginine, a Maillard reaction product in aged garlic extract

1999 ◽  
Vol 10 (6) ◽  
pp. 372-376 ◽  
Author(s):  
Nagatoshi Ide ◽  
Benjamin H.S. Lau ◽  
Kenjiro Ryu ◽  
Hiromichi Matsuura ◽  
Yoichi Itakura
Keyword(s):  
Maillard Reaction ◽  
Garlic Extract ◽  
Aged Garlic Extract ◽  
Maillard Reaction Product ◽  
Antioxidant Effects ◽  
Aged Garlic

Antioxidant effects of tetrahydro-β-carboline derivatives identified in aged garlic extract

BioFactors ◽  
2002 ◽  
Vol 16 (3-4) ◽  
pp. 57-72 ◽  
Author(s):  
Makoto Ichikawa ◽  
Kenjiro Ryu ◽  
Jiro Yoshida ◽  
Nagatoshi Ide ◽  
Susumu Yoshida ◽  
...  
Keyword(s):  
Garlic Extract ◽  
Aged Garlic Extract ◽  
Antioxidant Effects ◽  
Aged Garlic
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