Aged garlic extract ameliorates the oxidative stress, histomorphological, and ultrastructural changes of cisplatin-induced nephrotoxicity in adult male rats

2015 ◽  
Vol 78 (6) ◽  
pp. 452-461 ◽  
Author(s):  
Ashraf Youssef Nasr ◽  
Amal Al Shahat Ibrahim
Keyword(s):  
Oxidative Stress ◽  
Adult Male ◽  
Garlic Extract ◽  
Male Rats ◽  
Ultrastructural Changes ◽  
Aged Garlic Extract ◽  
Aged Garlic

scholarly journals The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Ana L. Colín-González ◽  
Ricardo A. Santana ◽  
Carlos A. Silva-Islas ◽  
Maria E. Chánez-Cárdenas ◽  
Abel Santamaría ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Molecular Mechanisms ◽  
Original Data ◽  
Garlic Extract ◽  
Protective Effects ◽  
Aged Garlic Extract ◽  
Antioxidant Mechanisms ◽  
Aged Garlic

Aged garlic extract (AGE) is an odorless garlic preparation containing S-allylcysteine (SAC) as its most abundant compound. A large number of studies have demonstrated the antioxidant activity of AGE and SAC in bothin vivo—in diverse experimental animal models associated to oxidative stress—andin vitroconditions—using several methods to scavenge reactive oxygen species or to induce oxidative damage. Derived from these experiments, the protective effects of AGE and SAC have been associated with the prevention or amelioration of oxidative stress. In this work, we reviewed different antioxidant mechanisms (scavenging of free radicals and prooxidant species, induction of antioxidant enzymes, activation of Nrf2 factor, inhibition of prooxidant enzymes, and chelating effects) involved in the protective actions of AGE and SAC, thereby emphasizing their potential use as therapeutic agents. In addition, we highlight the ability of SAC to activate Nrf2 factor—a master regulator of the cellular redox state. Here, we include original data showing the ability of SAC to activate Nrf2 factor in cerebral cortex. Therefore, we conclude that the therapeutic properties of these molecules comprise cellular and molecular mechanisms at different levels.

Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats

Life Sciences ◽  
2003 ◽  
Vol 73 (20) ◽  
pp. 2543-2556 ◽  
Author(s):  
Perla D Maldonado ◽  
Diana Barrera ◽  
Omar N Medina-Campos ◽  
Rogelio Hernández-Pando ◽  
Marı́a E Ibarra-Rubio ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Damage ◽  
Garlic Extract ◽  
Aged Garlic Extract ◽  
And Oxidative Stress ◽  
Aged Garlic

Cardioprotective roles of aged garlic extract, grape seed proanthocyanidin, and hazelnut on doxorubicin-induced cardiotoxicity

2009 ◽  
Vol 87 (8) ◽  
pp. 633-640 ◽  
Author(s):  
Erkan Demirkaya ◽  
Aslıhan Avci ◽  
Vural Kesik ◽  
Yıldırım Karslioglu ◽  
Emin Oztas ◽  
...  
Keyword(s):  
Grape Seed ◽  
Garlic Extract ◽  
Natural Antioxidant ◽  
Male Rats ◽  
Free Oxygen Radicals ◽  
Protective Effects ◽  
Aged Garlic Extract ◽  
Positive Effects ◽  
Grape Seed Proanthocyanidin ◽  
Aged Garlic

Doxorubicin (DXR) is a chemotherapeutic agent used effectively in the treatment of several childhood malignancies. During treatment, cardiotoxicity caused by cell damage due to the free oxygen radicals that are generated is a major limiting factor. This study was undertaken to determine whether DXR-induced cardiotoxicity could be prevented by natural foods with antioxidant properties such as aged garlic extract (AGEX), grape seed proanthocyanidin (PA), and hazelnut. Wistar albino male rats were assigned randomly to 9 groups each consisting of 15 rats. AGEX, PA, and hazelnut groups received these antioxidants in addition to their standard rat diet. They were also treated with cumulative intraperitoneal (i.p.) injections according to 2 different regimens: either a high-dose of 15 mg/kg DXR (3.75 mg/kg per week for 4 weeks) or a low-dose of 7.5 mg/kg DXR (1.875 mg/kg per week for 4 weeks). The control group received i.p. 0.9% saline. AGEX, PA, or hazelnut supplements were given orally to the groups for a 6-week period starting 1 week before the DXR treatment and ending 1 week after the treatment. One week after the last DXR injection, heart tissue samples were analyzed to determine malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and xanthine oxidase (XO) levels, and serum samples were taken for creatine kinase (CK). There were no significant changes in MDA levels among the control, DXR-treated groups, or supplemented groups that received additional natural antioxidant foods. SOD enzyme levels were decreased in rats treated with DXR. PA prevented the decrease at low doses of DXR. DXR treatment decreased CAT enzyme levels, but additional PA and hazelnut consumption increased these levels at low cumulative doses. XO enzyme levels were decreased in AGEX and hazelnut groups, but PA prevented the decrease. CK levels were elevated after DXR administration, indicating myocardial injury, but PA significantly reversed this. Although there were no differences histopathologically between AGEX, PA, and hazelnut groups, the protective effects of AGEX and PA were evident in electron microscopy. In conclusion, the positive effects of natural antioxidant foods on the prevention of DXR-induced cardiac injury could not be clearly shown on the basis of antioxidant enzymes. However, the electron microscopic changes clearly demonstrated the protective effects of AGEX and PA. The supplementation of these antioxidant foods over longer periods may show more definitive results. Human studies with different doses are needed to evaluate the effects of these foods on the human heart.

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