scholarly journals Management of cervical cancer stage Ib1 with poor prognosis during pregnancy: two

2012 ◽  
Vol 4 ◽  
pp. 291-295 ◽  
Author(s):  
Maja Kufelnicka-Babout ◽  
Dorota Kolasa-Zwierzchowska ◽  
Grzegorz Stachowiak ◽  
Małgorzata Zielińska ◽  
Hanna Romanowicz-Makowska ◽  
...  
2012 ◽  
Vol 153 (11) ◽  
pp. 435-437
Author(s):  
Péter Sámuel Nagy ◽  
Zoltán Tóth ◽  
Péter Gőcze ◽  
László Ádám

This report presents the history of a 35-year-old patient with adenoid cystic cervical cancer stage IIIB. Adenoid cystic carcinoma of the uterine cervix is a rare disease with poor prognosis. Following irradiation therapy, the patient was declared tumor free, and 20 years after diagnosis and treatment, she has no pathological signs or symptoms. Orv. Hetil., 2012, 153, 435–437.


2021 ◽  
Author(s):  
Grace Lee ◽  
Edward Christopher Dee ◽  
E. John Orav ◽  
Daniel W. Kim ◽  
Paul L. Nguyen ◽  
...  

2021 ◽  
Author(s):  
Shigemasa Takamizawa ◽  
Shu Yazaki ◽  
Yuki Kojima ◽  
Hiroshi Yoshida ◽  
Rui Kitadai ◽  
...  

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Chunyu Zhang ◽  
Pan Liu ◽  
Jiaming Huang ◽  
Yuandong Liao ◽  
Chaoyun Pan ◽  
...  

AbstractCircular RNAs (circRNAs) are known to act as key regulators in a variety of malignancies. However, the role of circRNAs in cervical cancer (CCa) remains largely unknown. Herein, we demonstrated that a circRNA derived from the TADA2A gene (hsa_circ_0043280) was significantly downregulated in CCa and that this reduction in expression was correlated with a poor prognosis. Furthermore, our results demonstrated that hsa_circ_0043280 functions as a tumor suppressor to inhibit tumor growth and metastasis in CCa. Mechanistically, hsa_circ_0043280 competitively sponges miR-203a-3p and prevents miR-203a-3p from reducing the levels of PAQR3. Collectively, our results demonstrate that hsa_circ_0043280 plays a pivotal role in the development and metastasis of CCa, thus suggesting that hsa_circ_0043280 has significant potential as a prognostic biomarker and a therapeutic target for CCa.


2021 ◽  
Vol 11 ◽  
Author(s):  
Qiming Wang ◽  
Yan Cai ◽  
Xuewen Fu ◽  
Liang Chen

In recent years, the incidence and the mortality rate of cervical cancer have been gradually increasing, becoming one of the major causes of cancer-related death in women. In particular, patients with advanced and recurrent cervical cancers present a very poor prognosis. In addition, the vast majority of cervical cancer cases are caused by human papillomavirus (HPV) infection, of which HPV16 infection is the main cause and squamous cell carcinoma is the main presenting type. In this study, we performed screening of differentially expressed genes (DEGs) based on The Cancer Genome Atlas (TCGA) database and GSE6791, constructed a protein–protein interaction (PPI) network to screen 34 hub genes, filtered to the remaining 10 genes using the CytoHubba plug-in, and used survival analysis to determine that RPS27A was most associated with the prognosis of cervical cancer patients and has prognostic and predictive value for cervical cancer. The most significant biological functions and pathways of RPS27A enrichment were subsequently investigated with gene set enrichment analysis (GSEA), and integration of TCGA and GTEx database analyses revealed that RPS27A was significantly expressed in most cancer types. In this study, our analysis revealed that RPS27A can be used as a prognostic biomarker for HPV16 cervical cancer and has biological significance for the growth of cervical cancer cells.


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