scholarly journals Hepatomegaly, weight loss and general malaise – the first manifestations of primary systemic amyloidosis

2014 ◽  
Vol 1 ◽  
pp. 57-61 ◽  
Author(s):  
Halina Cichoż-Lach ◽  
Beata Prozorow-Król ◽  
Jarosław Swatek ◽  
Barbara Skrzydło-Radomańska ◽  
Leszek Buk ◽  
...  
Keyword(s):  
Weight Loss ◽  
Systemic Amyloidosis ◽  
General Malaise

Chronic Haemolytic Anemia and Splenomegaly in a Patient with an Isolated Adrenocorticotropin Deficiency

2008 ◽  
Vol 1 ◽  
pp. CMED.S406
Author(s):  
Rania Abdel-Muneem Ahmed ◽  
Koji Murao ◽  
Hitomi Imachi ◽  
Noriko Kitanaka ◽  
Tomie Muraoka ◽  
...  
Keyword(s):  
Weight Loss ◽  
General Malaise ◽  
Laboratory Studies ◽  
Adrenocortical Insufficiency ◽  
Progressive Weight Loss ◽  
Haemolytic Anemia

Herein we describe a case of a 56-years old patient presented with general malaise, anorexia and progressive weight loss for about 5years associated recently with diarrhoea and repeated syncopal attacks for 1month. On admission, he had splenomegaly and his laboratory studies showed macrocytic hyperchromic haemolytic anemia [Hb = 9.4g/dl] and a significant hyponatremia [Na+ = 111mmol/l]. Endocrinological evaluation revealed an isolated adrenocorticotropin deficiency (IAD) with a manifest hypoaldosteronism. On treatment with cortisone, both anemia and hyponatremia (but not splenomegaly) were markedly improved. Our case may represent an evidence for the pathogenesis of erythropoietic dysfunction in patients of adrenocortical insufficiency.

Generalised eruptive histiocytosis preceded by systemic symptoms

2021 ◽  
Vol 14 (6) ◽  
pp. e243411
Author(s):  
Caitlyn N Myrdal ◽  
Delaney B Stratton ◽  
Tracy L Davis ◽  
Clara Curiel-Lewandrowski
Keyword(s):  
Weight Loss ◽  
Chronic Inflammation ◽  
Spindle Cell ◽  
Langerhans Cell ◽  
Histological Evaluation ◽  
General Malaise ◽  
Histological Findings ◽  
Proliferative Disease ◽  
Systemic Symptoms ◽  
Dermal Infiltrate

Generalised eruptive histiocytosis is a rare proliferative disease that typically presents with indolent cutaneous eruptions. We describe the case of a 73-year-old man presenting with diffuse, asymptomatic crops of pink to dusky red papules preceded by general malaise, myalgias, fluctuating fever, chills, and weight loss. Histological evaluation revealed a non-Langerhans cell histiocytic dermal infiltrate with spindle cell features and chronic inflammation, reactive for CD68 and negative for both S100 and CD1a. Malignancy screening was negative. This report aims to highlight a unique presentation of generalised eruptive histiocytosis, emphasise histological findings, and discuss considerations for malignancy screening.

scholarly journals Systemic Amyloidosis: A Rare Presentation of Mesenteric Angina

2002 ◽  
Vol 16 (10) ◽  
pp. 683-685 ◽  
Author(s):  
Christopher N Andrews ◽  
Jack N Amar ◽  
Malcolm MM Hayes ◽  
Robert A Enns
Keyword(s):  
Computed Tomography ◽  
Weight Loss ◽  
Cardiac Arrest ◽  
Epigastric Pain ◽  
Systemic Amyloidosis ◽  
Rare Presentation ◽  
Arterial Involvement ◽  
Rare Manifestation ◽  
History Of ◽  
Ischemic Enteritis

A 64-year-old man presented with an eight-month history of increasing postprandial epigastric pain and a 15 kg weight loss. Computed tomography of the abdomen, panendoscopy and mesenteric angiography failed to explain the cause of the patient's mesenteric angina. Systemic amyloidosis involving intestinal small vasculature without larger arterial involvement was diagnosed at autopsy after the patient died of an asystolic cardiac arrest. Mesenteric angina without evidence of ischemic enteritis or pseudo-obstruction is a rare manifestation of amyloidosis.

scholarly journals Systemic amyloidosis and pneumatosis of bladder wall

2015 ◽  
Vol 5 (2S) ◽  
pp. 47-54
Author(s):  
Erica Delsignore ◽  
Luciano Bellan ◽  
Maria Cristina Bertoncelli ◽  
Roberto Cantone ◽  
Margherita Francese ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Weight Loss ◽  
Clinical Condition ◽  
Clinical Evidence ◽  
Bladder Wall ◽  
Systemic Amyloidosis ◽  
Histological Evidence

A 72-year-old woman was admitted to our Department for syncopes, diarrhoea, and weight loss. We suspected the diagnosis of systemic amyloidosis after the detection of macroglossia and periorbital purpura, despite the biopsy of the previous year, that resulted negative for amyloid substance. We confirmed the diagnosis after the histological evidence of deposits of amyloid in bone marrow and the clinical evidence of pneumatosis of bladder wall. Chemotherapy improved only temporarily clinical condition.

scholarly journals Primary Systemic Amyloidosis - an Unusual Cause of Diarrhea

2019 ◽  
Vol 70 (9) ◽  
pp. 3267-3268
Author(s):  
Carmen Plaisanu ◽  
Vlad Dumitru Baleanu ◽  
Dragos Virgil Davitoiu ◽  
Corina Meianu ◽  
Mircea Diculescu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Digestive Tract ◽  
Rare Diseases ◽  
Systemic Amyloidosis ◽  
Gastrointestinal Involvement ◽  
Systemic Involvement ◽  
Upper Digestive Tract ◽  
Multiple Organs ◽  
Endoscopic Biopsies

The amyloidosis is a group of rare diseases caused by extracellular deposition of amyloid. It may affect multiple organs with protean manifestations, thus often causing delayed or incorrect diagnoses. We report a case of gastrointestinal involvement in primary systemic amyloidosis (PSA) in a patient complaining of diarrhea and weight loss. The diagnosis was confirmed by endoscopic biopsies of upper digestive tract and by multidisciplinary evaluation for systemic involvement.

scholarly journals Primary Systemic Amyloidosis: a Case Report and Review of Clinical Features

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Hu HQ ◽  
Wang SC ◽  
Cao X ◽  
Cao BZ
Keyword(s):  
Heart Failure ◽  
Weight Loss ◽  
Nephrotic Syndrome ◽  
Peripheral Neuropathy ◽  
Sural Nerve ◽  
Histopathological Examination ◽  
Clinical Signs ◽  
Pericardial Fluid ◽  
Systemic Amyloidosis ◽  
Symptoms And Signs

Primary systemic amyloidosis is a rare disorder that has multisystemic manifestations. The diagnosis is very difficult because of non-specific clinical signs. We report a patient with primary systemic amyloidosis manifesting as peripheral neuropathy, nephrotic syndrome, gastrointestinal syndrome, orthostatic hypotension, pericardial fluid, weight loss and so on. Histopathological examination of kidney and sural nerve showed Congo red positive deposits. Primary systemic amyloidosis should be considered in any patient older than 40 years who has the following symptoms and signs: fatigue, weight loss, edema, paresthesias, muscle weakness, noninfectious diarrhea, skin and soft-tissue lesions, and the complications of nephrotic syndrome, congestive heart failure (not on an ischemic basis), peripheral neuropathy, or unexplained hepatomegaly. All patients need the diagnosis confirmed histologically by biopsy of an involved organ.

Equine liver disease in the field. Part 1: approach

UK-Vet Equine ◽  
2020 ◽  
Vol 4 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Rose Tallon ◽  
Kate McGovern
Keyword(s):  
Weight Loss ◽  
Liver Disease ◽  
Liver Function ◽  
Liver Biopsy ◽  
Clinical Signs ◽  
Serum Biochemistry ◽  
General Malaise ◽  
Limited Information ◽  
Function Form

Liver disease in adult horses is commonly identified during investigation of non-specific clinical signs such as general malaise, lethargy or weight loss. In some cases, disease may be advanced and irreversible by the time a diagnosis is reached. Serum biochemistry and tests of liver function form an important part of diagnosing liver disease but provide limited information regarding aetiology, severity and prognosis. Liver biopsy is recommended in the majority of cases to confirm the presence of disease, to guide therapeutics and to provide information regarding prognosis.

Experimental Amyloidosis Induced by Immune Complex

1971 ◽  
Vol 29 ◽  
pp. 582-583
Author(s):  
A. Kawaoi
Keyword(s):  
Immune Complex ◽  
Systemic Amyloidosis ◽  
Human Diseases ◽  
Experimental Amyloidosis ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Immunological Approach ◽  
Experimentally Induced

Numbers of immunological approach have been made to the amyloidosis through the variety of predisposing human diseases and the experimentally induced animals by the greater number of agents. The results suggest an important role of impaired immunity involving both humoral and cell-mediated aspects.Recently the author has succeeded in producing amyloidosis in the rabbits and mice by the injections of immune complex of heat denatured DNA.The aim of this report is to demonstrate the details of the ultrastructure of the amyloidosis induced by heterologous insoluble immune complex. Eleven of twelve mice, dd strain, subcutaneously injected twice a week with Freund's complete adjuvant and four of seven animals intraperitonially injected developed systemic amyloidosis two months later from the initial injections. The spleens were electron microscopically observed.

Sign in / Sign up

Export Citation Format

Share Document