scholarly journals ISOBOLOGRAPHIC ASSESSMENT OF INTERACTIONS BETWEEN RETIGABINE AND PHENYTOIN IN THE MOUSE MAXIMAL ELECTROSHOCK-INDUCED SEIZURE MODEL AND CHIMNEY TEST

2016 ◽  
Vol 4 ◽  
pp. 54-59 ◽  
Author(s):  
Dorota Żółkowska ◽  
Mirosław Zagaja ◽  
Barbara Miziak ◽  
Maria W. Kondrat-Wróbel ◽  
Katarzyna Załuska ◽  
...  
Keyword(s):  
Maximal Electroshock ◽  
Seizure Model ◽  
Chimney Test

Verapamil enhances the anticonvulsant effect of oxcarbazepine in the maximal electroshock-induced seizure model in mice

2009 ◽  
Vol 22 (2) ◽  
pp. 115-124
Author(s):  
Anna Zadrożniak ◽  
MichaŁ K. Trojnar ◽  
Marcin P. Trojnar ◽  
Żaneta Kimber-Trojnar ◽  
Monika Dudra-Jastrzębska ◽  
...  
Keyword(s):  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Seizure Model

scholarly journals How Antidepressant Drugs Affect the Antielectroshock Action of Antiseizure Drugs in Mice: A Critical Review

2021 ◽  
Vol 22 (5) ◽  
pp. 2521
Author(s):  
Kinga K. Borowicz-Reutt
Keyword(s):  
Antiepileptic Drugs ◽  
Neurotrophic Factor ◽  
Antidepressant Drugs ◽  
Drug Effects ◽  
Mechanisms Of Action ◽  
Maximal Electroshock ◽  
Anticonvulsant Action ◽  
Mes Test ◽  
Seizure Model ◽  
Glial Derived Neurotrophic Factor

Depression coexists with epilepsy, worsening its course. Treatment of the two diseases enables the possibility of interactions between antidepressant and antiepileptic drugs. The aim of this review was to analyze such interactions in one animal seizure model—the maximal electroshock (MES) in mice. Although numerous antidepressants showed an anticonvulsant action, mianserin exhibited a proconvulsant effect against electroconvulsions. In most cases, antidepressants potentiated or remained ineffective in relation to the antielectroshock action of classical antiepileptic drugs. However, mianserin and trazodone reduced the action of valproate, phenytoin, and carbamazepine against the MES test. Antiseizure drug effects were potentiated by all groups of antidepressants independently of their mechanisms of action. Therefore, other factors, including brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) modulation, should be considered as the background for the effect of drug combinations.

Synergistic Interaction of Retigabine with Levetiracetam in the Mouse Maximal Electroshock-Induced Seizure Model: A Type II Isobolographic Analysis

Pharmacology ◽  
2015 ◽  
Vol 96 (1-2) ◽  
pp. 11-15 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Mirosław Zagaja ◽  
Barbara Miziak ◽  
Magdalena Florek-Luszczki ◽  
Stanislaw J. Czuczwar
Keyword(s):  
Synergistic Interaction ◽  
Maximal Electroshock ◽  
Type Ii ◽  
Isobolographic Analysis ◽  
Seizure Model
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