Synergistic Interaction of Retigabine with Levetiracetam in the Mouse Maximal Electroshock-Induced Seizure Model: A Type II Isobolographic Analysis

Pharmacology ◽  
2015 ◽  
Vol 96 (1-2) ◽  
pp. 11-15 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Mirosław Zagaja ◽  
Barbara Miziak ◽  
Magdalena Florek-Luszczki ◽  
Stanislaw J. Czuczwar
Keyword(s):  
Synergistic Interaction ◽  
Maximal Electroshock ◽  
Type Ii ◽  
Isobolographic Analysis ◽  
Seizure Model

scholarly journals Effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the protective action of various antiepileptic drugs in the maximal electroshock-induced seizure model: a type II isobolographic analysis

2013 ◽  
Vol 120 (12) ◽  
pp. 1651-1663 ◽  
Author(s):  
Marta Andres-Mach ◽  
Anna Zadrożniak ◽  
Agnieszka Haratym-Maj ◽  
Magdalena Florek-Luszczki ◽  
Grzegorz Raszewski ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
Protective Action ◽  
Maximal Electroshock ◽  
Type Ii ◽  
Isobolographic Analysis ◽  
Seizure Model

scholarly journals Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis

2015 ◽  
Vol 28 (3) ◽  
pp. 204-207 ◽  
Author(s):  
Aleksandra Wlaz ◽  
Maria W. Kondrat-Wrobel ◽  
Katarzyna Zaluska ◽  
Ewelina Kochman ◽  
Anna R. Rekas ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Stimulus Duration ◽  
Synergistic Interaction ◽  
Type Ii ◽  
Isobolographic Analysis ◽  
Swiss Mice ◽  
Psychomotor Seizure ◽  
Seizure Model ◽  
A Current ◽  
Anticonvulsant Effects

Abstract This study was aimed at characterizing the anticonvulsant effects of levetiracetam in combination with gabapentin, in the mouse 6 Hz psychomotor seizure model. Herein, psychomotor seizures were evoked in male albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes. Type II isobolographic analysis was used to characterize the anticonvulsant interactions between the drugs in combination, for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. The type II isobolographic analysis revealed that the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. We conclude that, as the combinations of levetiracetam with gabapentin for the fixed-ratios of 1:5 and 1:10 exerted supra-additive (synergistic) interaction in the mouse 6 Hz psychomotor seizure model, this may be considered as particularly favorable combinations in further clinical practice.

scholarly journals Interactions among Lacosamide and Second-Generation Antiepileptic Drugs in the Tonic-Clonic Seizure Model in Mice

2021 ◽  
Vol 22 (11) ◽  
pp. 5537
Author(s):  
Katarzyna Załuska-Ogryzek ◽  
Paweł Marzęda ◽  
Paula Wróblewska-Łuczka ◽  
Magdalena Florek-Łuszczki ◽  
Zbigniew Plewa ◽  
...  
Keyword(s):  
Second Generation ◽  
Screen Test ◽  
Clonic Seizure ◽  
Tonic Clonic Seizure ◽  
Maximal Electroshock ◽  
Isobolographic Analysis ◽  
Clonic Seizures ◽  
Seizure Model

Combination therapy with two or three antiseizure medications (ASMs) is sometimes a preferred method of treatment in epilepsy patients. (1) Background: To detect the most beneficial combination among three ASMs, a screen test evaluating in vivo interactions with respect to their anticonvulsant properties, was conducted on albino Swiss mice; (2) Methods: Classification of interactions among lacosamide (LCM) and selected second-generation ASMs (lamotrigine (LTG), pregabalin (PGB), oxcarbazepine (OXC), and topiramate (TPM)) was based on the isobolographic analysis in the mouse maximal electroshock-induced seizure (MES) model. Interactions among LCM and second-generation ASMs were visualized using a polygonogram; (3) Results: In the mouse MES model, synergy was observed for the combinations of LCM + TPM + PGB and LCM + OXC + PGB. Additivity was reported for the other combinations tested i.e., LCM + LTG + TPM, LCM + LTG + PGB, LCM + LTG + OXC, and LCM + OXC + TPM in this seizure model. No adverse effects associated with triple ASM combinations, containing LCM and second-generation ASMs were observed in mice; (4) Conclusions: The combination of LCM + TPM + PGB was the most beneficial combination among the tested in this study, offering synergistic suppression of tonic-clonic seizures in mice subjected to the MES model. Both the isobolographic analysis and polygonogram method can be recommended for experimental epileptology when classifying interactions among the ASMs.

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