scholarly journals Combination therapy with prednisone and cyclophosphamide in a 14-year-old boy with pemphigus foliaceus – a case report

2017 ◽  
Vol 3 ◽  
pp. 324-330
Author(s):  
Magdalena Salińska ◽  
Kamil Trambowicz ◽  
Joanna Narbutt ◽  
Anna Woźniacka ◽  
Aleksandra Lesiak
Keyword(s):  
Case Report ◽  
Combination Therapy ◽  
Pemphigus Foliaceus

scholarly journals Combination therapy with azathioprine, cyclosporine and ketoconazole in a dog with concurrent pemphigus foliaceus and hyperadrenocorticism – Case report

2020 ◽  
Author(s):  
Taesik Yun ◽  
Yoonhoi Koo ◽  
Sanggu Kim ◽  
Hakhyun Kim ◽  
Soochong Kim ◽  
...  
Keyword(s):  
Case Report ◽  
Combination Therapy ◽  
Clinical Signs ◽  
Poor Response ◽  
Pemphigus Foliaceus ◽  
Once Daily ◽  
First Case ◽  
History Of ◽  
Erythematous Plaques

AbstractA 10-year-old, spayed female Shih Tzu dog presented with a history of progressive erythema and multiple crusts developing 85 days previously. The dog had been diagnosed with hyperadrenocorticism (HAC) 55 days prior to presentation and was treated with oral trilostane (2.86 mg/kg, once daily) that was discontinued due to a poor response. In addition to generalised alopecia, erythematous plaques and crusts were noted on the trunk, head and footpads. Lesional impression smears revealed numerous acantholytic cells and non-degenerated neutrophils. Histopathological findings demonstrated subcorneal pustules with acantholytic cells and intact neutrophils. On the basis of these findings, we diagnosed pemphigus foliaceus (PF) with concurrent HAC. We wished to avoid glucocorticoids and, therefore, prescribed oral, once-daily azathioprine (2 mg/kg), modified cyclosporine (7 mg/kg) and ketoconazole (5 mg/kg). By day 71 post-treatment, the erythematous crusts had almost disappeared and the alopecia had improved considerably. However, by the subsequent follow-up examination on day 99, the clinical signs had reappeared due to the tapering of cyclosporine. To the best of our knowledge, this is the first case report describing concurrent PF and HAC in a dog. Combination therapy with azathioprine, modified cyclosporine and ketoconazole was effective, and should be considered for dogs diagnosed with concurrent autoimmune diseases and HAC.

scholarly journals Dopamine agonist and tamoxifen combination therapy for a prolactin-secreting pituitary tumor resistant to dopamine agonist monotherapy: Case report and review

2020 ◽  
Vol 21 ◽  
pp. 100777
Author(s):  
Zachary K. Christian ◽  
Kimmo J. Hatanpaa ◽  
Richard J. Auchus ◽  
Stephen R. Hammes ◽  
Ankur R. Patel ◽  
...  
Keyword(s):  
Case Report ◽  
Combination Therapy ◽  
Dopamine Agonist ◽  
Pituitary Tumor

scholarly journals Isolated renal mucormycosis in a patient with Idiopathic CD4 lymphocytopenia

2018 ◽  
pp. bcr-2018-225234
Author(s):  
Jasmine Sethi ◽  
Raja Ramachandran ◽  
Harbir Singh Kohli ◽  
Krishan Lal Gupta
Keyword(s):  
Case Report ◽  
Combination Therapy ◽  
Autoimmune Hepatitis ◽  
Lymphocyte Count ◽  
Multidisciplinary Approach ◽  
Early Stage ◽  
Fatal Disease ◽  
Cd4 Lymphocyte Count ◽  
Cd4 Lymphocyte ◽  
Idiopathic Cd4 Lymphocytopenia

Idiopathic CD4 lymphocytopenia (ICL) is characterised by a low CD4 +lymphocyte count in the absence of HIV or other underlying aetiologies. We report a case of a 17-year-old girl with ICL with autoimmune hepatitis who developed isolated renal mucormycosis, which, to our knowledge, is the first reported case described in literature. Combination therapy with antifungals and surgical resection was done, and the patient improved. This case report illustrates the importance of timely multidisciplinary approach to recognise this highly fatal disease at an early stage.

scholarly journals Successful Combination Therapy of Trazodone and Fluvoxamine for Pica in Alzheimer's Disease: A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Tadashi Kanamori ◽  
Yoshiyuki Kaneko ◽  
Kouju Yamada ◽  
Masahiro Suzuki
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Case Report ◽  
Drug Therapy ◽  
Combination Therapy ◽  
Frontotemporal Dementia ◽  
Late Stage ◽  
Daytime Sleepiness ◽  
Extrapyramidal Symptoms ◽  
Common Drug

Pica in Alzheimer's disease (AD) makes it difficult for caregivers to provide care. However, few effective medications have been reported for pica in AD. We report a case of AD with pica that was successfully improved by trazodone and fluvoxamine. An 80-year-old woman with AD was admitted to our hospital due to aggravated pica, including eating weeds in the facility's garden and eating a dishwashing sponge. Her pica was accompanied by oral tendency, prosopagnosia, and placidity. She took rivastigmine and memantine, but these were ineffective for her pica. She was given olanzapine and perospirone, but both were discontinued due to over-sedation and severe extrapyramidal symptoms, respectively. We then administered trazodone and fluvoxamine, both of which have demonstrated effectiveness for pica in frontotemporal dementia (FTD). Her pica behaviors then disappeared without daytime sleepiness. In this case, pica with oral tendency, which was accompanied by prosopagnosia and placidity, may be interpreted as a partial symptom of Klüver–Bucy syndrome (KBS). KBS is often seen in FTD, but also occurs in late-stage AD. Our case together with previous reports showing that trazodone and fluvoxamine were effective for pica in FTD suggest that the same common drug therapy may be successful in pica with oral tendency, regardless of the subtype of dementia.

scholarly journals Erosive Lichen Planus on the Extremities During Combination Therapy with Nivolumab and Radiation: A Second Case Report

2020 ◽  
Vol 100 (6) ◽  
pp. adv00100-2 ◽  
Author(s):  
K Katsuo ◽  
T Honda ◽  
T Komori ◽  
Y Kaku ◽  
K Kabashima
Keyword(s):  
Case Report ◽  
Combination Therapy ◽  
Lichen Planus ◽  
Erosive Lichen Planus
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