scholarly journals Psoriasis vulgaris, bullous pemphigoid, metabolic syndrome – coincidence or common pathogenetic background?

2014 ◽  
Vol 4 ◽  
pp. 294-298
Author(s):  
Agnieszka Kalińska-Bienias ◽  
Anna Leśniewska ◽  
Piotr Bienias ◽  
Cezary Kowalewski ◽  
Katarzyna Woźniak
1988 ◽  
Vol 50 (6) ◽  
pp. 1018-1021 ◽  
Author(s):  
Nobuaki TAKE ◽  
Tetsuya HIRANO ◽  
Osamu IYOTA ◽  
Yoshinori SUENAGA

2015 ◽  
Vol 25 (1) ◽  
pp. 70-71
Author(s):  
Chihiro Nakayama ◽  
Hiroaki Iwata ◽  
Naoya Haga ◽  
Yohei Hamade ◽  
Osamu Mizuno ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Yu Liu ◽  
Xin Li ◽  
Yan-Ping Huang ◽  
Zi-Yu Cui ◽  
Jia Bao ◽  
...  

Aim. Psoriasis is a chronic inflammatory disease with a complex etiology, and psoriasis vulgaris (PsV) is the most common type of psoriasis. Recent studies suggest the relationship between psoriasis and metabolic syndrome in different ethnicities. This study is aimed at evaluating the association of metabolism-related gene variants with the risk of PsV in Chinese Han population. Material and Methods. PsV patients (1030) and healthy controls (965) were enrolled in this study. Eighteen single-nucleotide polymorphisms (SNPs) previously reported to be significantly associated with metabolic syndrome were selected. SNPs were detected by next-generation sequencing. Results. Seven SNPs were significantly associated with PsV: rs805303 ( P = 0.012 , OR = 0.85 ), rs3177928 ( P = 1.37 × 10 − 15 , OR = 2.51 ), and rs2247056 ( P = 3.73 × 10 − 4 , OR = 0.67 ) located in the HLA gene region; rs1047781 ( P = 0.012 , OR = 1.18 ), rs281379 ( P = 0.014 , OR = 1.71 ), and rs492602 ( P = 0.005 , OR = 1.86 ) located in the FUT2 region; and rs2303138 ( P = 0.014 , OR = 1.18 ) located in the LNPEP region. After stratified analysis, rs805303 ( P = 0.017 , OR = 0.74 ) and rs2303138 ( P = 0.041 , OR = 1.30 ) were associated with PsVs when HLA-C ∗ 06 : 02 was positive, and rs805303 ( P = 5.62 × 10 − 5 , OR = 0.68 ), rs3177928 ( P = 0.003 , OR = 1.75 ), rs281379 ( P = 0.034 , OR = 1.96 ), and rs492602 ( P = 0.025 , OR = 2.04 ) were associated with PsVs when HLA-C ∗ 06 : 02 was negative. Conclusion. PsV and metabolic syndrome may have overlapped susceptible genes in Chinese Han population.


2020 ◽  
Vol Volume 13 ◽  
pp. 1005-1013
Author(s):  
Essam A Nada ◽  
Eman MS Muhammad ◽  
Sheren FM Ahmed ◽  
Asmaa MS Tamam ◽  
Amr Abdelhamed

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