scholarly journals Assessment of the Effect of Metabolic Syndrome on the Autophagy Marker LC3 in Psoriasis Vulgaris Patients: A Cross-Sectional Study

2020 ◽  
Vol Volume 13 ◽  
pp. 1005-1013
Author(s):  
Essam A Nada ◽  
Eman MS Muhammad ◽  
Sheren FM Ahmed ◽  
Asmaa MS Tamam ◽  
Amr Abdelhamed
Author(s):  
Pankti Manit Gundavda ◽  
Priyanka Chandrakant Patil ◽  
Dipak D. Umrigar

<p><strong>Background:</strong> Psoriasis is a common, chronic, inflammatory keratinization disorder of the skin. It can be triggered by many environmental as well as genetic factors.  The metabolic syndrome (syndrome X, insulin resistance syndrome) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease (CVD) and diabetes mellitus (DM). Often coexistence is noticed between psoriasis and metabolic syndrome.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in the Government medical college and new civil hospital, Surat. A total of 115 clinically diagnosed cases of psoriasis vulgaris and similar age and sex matched controls visiting dermatology out patients’ department of new civil hospital, Surat were selected for the study.</p><p><strong>Results:</strong> Prevalence of metabolic syndrome is significantly higher in psoriatic patients after the age of 40 years, and it directly correlates to psoriasis duration. No association observed with gender, percentage of body surface area involved and smoking, but in patients of 18-40 years with metabolic syndrome had significantly higher percentage of body surface area involved as compared to &gt;40 years age group.</p><p>Patients with metabolic syndrome had mean disease duration of 5.52±5.83 years and BMI was 27.48±4.36.</p><p><strong>Conclusions:</strong> Higher prevalence of metabolic syndrome in patients with psoriasis could play a relevant role in accelerating atherosclerosis. All patients with psoriasis should be encouraged to aggressively correct their modifiable cardiovascular risk factors.</p>


Author(s):  
Manjaree Morgaonkar ◽  
Ramesh Kushwaha ◽  
Savera Gupta ◽  
Suresh Kumar Jain ◽  
Dattatray V. Kulkarni ◽  
...  

<p class="abstract"><strong>Background:</strong> Psoriasis, a common skin disorder is now considered as systemic inflammatory disease. Its chronic inflammatory state is thought to predispose patients to metabolic syndrome (MetS), which is a significant predictor of cardiovascular events. The objective of the study is to investigate the prevalence of metabolic syndrome in psoriatic patients with only cutaneous involvement and to evaluate the correlation between presence of MetS and psoriasis severity</p><p class="abstract"><strong>Methods:</strong> We performed hospital based, cross-sectional study on 100 adult patients with psoriasis vulgaris and equi-numbered age and sex matched controls. MetS was diagnosed by revised National Cholesterol Education Program’s Adult Panel III criteria.</p><p class="abstract"><strong>Results:</strong> A higher prevalence of metabolic syndrome was found in psoriasis patients as compared to controls [28 (28%) vs 9 (9%), P value=0.0005].Impaired fasting glucose level, hypertension, hypertriglyceridemia and abdominal obesity were more prevalent in psoriasis group. No statistically significant difference was found between prevalence of low levels of HDL and presence of metabolic syndrome. Presence of metabolic syndrome was not associated with severity and duration of psoriasis. Female patients with psoriasis were more frequently having metabolic syndrome.</p><strong>Conclusions:</strong> Prevalence of metabolic syndrome is higher in patients with psoriasis irrespective of its duration and severity. This stresses on the need of regular evaluation for the presence of MetS or any of its components in psoriasis patients so as to allow early detection and management.


2019 ◽  
Vol 9 (2) ◽  
pp. 87-90
Author(s):  
Karanam Madhuri ◽  
◽  
Rishi Kumar Venkatachalam ◽  
A Nasreen Begum ◽  
Shamsheer Khan P ◽  
...  

2020 ◽  
Author(s):  
Mahshid Shahavandi ◽  
Hossein Shahinfar ◽  
Nastaran payande ◽  
Fatemeh Sheikhhossein ◽  
Kurosh Djafarian ◽  
...  

2021 ◽  
Vol 10 (13) ◽  
pp. 2812
Author(s):  
Cristina Bellarosa ◽  
Giorgio Bedogni ◽  
Annalisa Bianco ◽  
Sabrina Cicolini ◽  
Diana Caroli ◽  
...  

As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.


2007 ◽  
Vol 17 (4) ◽  
pp. 320-326 ◽  
Author(s):  
Min Jung Park ◽  
Kyung Eun Yun ◽  
Go Eun Lee ◽  
Hong Jun Cho ◽  
Hye Soon Park

BMC Medicine ◽  
2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Chengfu Cai ◽  
Mingzhu Lin ◽  
Yanfang Xu ◽  
Xuejun Li ◽  
Shuyu Yang ◽  
...  

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