scholarly journals Long non-coding RNA PTCSC3 inhibits human oral cancer cell proliferation by inducing apoptosis and autophagy

2020 ◽  
Author(s):  
Hongmei Zhang ◽  
Jiang Wang ◽  
Wenxing Xun ◽  
Jia Wang ◽  
Wei Song ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Oral Cancer Cell ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Yafeng Fan ◽  
Hongxia Li ◽  
Zhongping Yu ◽  
Wen Dong ◽  
Xiaoyan Cui ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Small Cell ◽  
Cancer Cell Proliferation ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Abstract Long non-coding RNA (lncRNA) FYVE, RhoGEF and PH domain containing 5 antisense RNA 1 (FGD5-AS1) has been reported as an oncogene in colorectal cancer, promoting its tumorgenesis. The present paper focused on searching the potential function of FGD5-AS1 in non-small cell lung carcinoma (NSCLC). There are connections between the expression of lncRNA FGD5-AS1 and human NSCLC tumor growth and progression. Also, the relationships between FGD5-AS1, hsa-miR-107 and mRNA fibroblast growth factor receptor like 1 (FGFRL1) are going to test their interaction in NSCLC cell lines, which may cause a series of biological behaviors of NSCLC cells. qRT-PCR analysis was conducted to test the expression of RNAs in different situation. CCK-8 experiment and clone formation assay were performed to assess proliferation of NSCLC cells. Also, connection between FGD5-AS1 and hsa-miR-107 were investigated by luciferase reporter assay and RNA pull-down assay. Rescue experiments were performed to verify the modulating relationship between FGD5-AS1, hsa-miR-107 and FGFRL1. High-level expression of FGD5-AS1 was found in NSCLC. FGD5-AS1 may promote the proliferation of NSCLC cells. Also, the combination between hsa-miR-107, FGD5-AS1 and NSCLC have been proved, which means they can play an interaction function in NSCLC cells. Thence, we concluded that lncRNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1.

scholarly journals A Long Non-coding RNA Lnc712 Regulates Breast Cancer Cell Proliferation

2020 ◽  
Vol 16 (1) ◽  
pp. 162-171 ◽  
Author(s):  
Yue Cui ◽  
Chunxiao Lu ◽  
Zhiming Zhang ◽  
Aiqin Mao ◽  
Lei Feng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Breast Cancer Cell Proliferation ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Triptolide represses oral cancer cell proliferation, invasion, migration, and angiogenesis in co-inoculation with U937 cells

2016 ◽  
Vol 21 (1) ◽  
pp. 419-427 ◽  
Author(s):  
Cheng-Yu Yang ◽  
Chih-Kung Lin ◽  
Gu-Jiun Lin ◽  
Cheng-Chih Hsieh ◽  
Shing-Hwa Huang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
U937 Cells ◽  
Oral Cancer Cell
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