Suppression of Long Non-Coding RNA RP1-93H18.6 Inhibits Cervical Cancer Cell Proliferation, Invasion, Migration and Adhesion Through the Blockade of PI3K/Akt Axis

2019 ◽  
Author(s):  
Qian Wang ◽  
Shu-Ping Yan ◽  
Dan-Xia Chu ◽  
Ya Xie ◽  
Chun-Fang Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Cervical Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA H19 enhances cell proliferation and anchorage-independent growth of cervical cancer cell lines

2016 ◽  
Vol 242 (2) ◽  
pp. 184-193 ◽  
Author(s):  
Tawin Iempridee
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Cancer Cell ◽  
Transforming Growth Factor ◽  
Cancer Cell Lines ◽  
Cervical Cancer Cell ◽  
Multicellular Tumor Spheroid ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA H19 is aberrantly expressed in multiple malignancies and its expression levels correlate with recurrence, metastasis, and patient survival. Despite numerous reports documenting the role of H19 in carcinogenesis, its contribution to cervical cancer development is still largely unknown. In this study, I observed that H19 expression was elevated in cervical cancer cell lines and could be detected in extracellular vesicles in the culture medium. In addition, I demonstrated, by overexpression and knockdown experiments, that H19 promoted cell proliferation and multicellular tumor spheroid formation without significantly affecting apoptosis and cell migration. Finally, treatment with transforming growth factor beta and hypoxia-mimetic CoCl2 could modulate H19 levels in a cell line-specific manner. These findings indicate that H19 promotes both anchorage-specific and -independent growth of cervical cancer cell lines and may serve as a potential target for cancer diagnosis and therapy.

scholarly journals Sesamin inhibits cervical cancer cell proliferation by promoting p53/PTEN-mediated apoptosis

2020 ◽  
Vol 17 (15) ◽  
pp. 2292-2298
Author(s):  
Tian-Ni Kuo ◽  
Chun-Shiang Lin ◽  
Guan-De Li ◽  
Cheng-Yi Kuo ◽  
Shao-Hsuan Kao
Keyword(s):  
Cervical Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Cervical Cancer Cell ◽  
Cancer Cell Proliferation
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